Excitotoxicity, Oxytosis/Ferroptosis, and Neurodegeneration: Emerging Insights into Mitochondrial Mechanisms DOI Creative Commons

Sameera Khan,

Nargis Bano,

Shakir Ahamad

и другие.

Aging and Disease, Год журнала: 2024, Номер unknown, С. 0 - 0

Опубликована: Янв. 1, 2024

Mitochondrial dysfunction plays a pivotal role in the development of age-related diseases, particularly neurodegenerative disorders. The etiology mitochondrial involves multitude factors that remain elusive. This review centers on elucidating role(s) excitotoxicity, oxytosis/ferroptosis and neurodegeneration within context bioenergetics, biogenesis, mitophagy oxidative stress explores their intricate interplay pathogenesis diseases. effective coordination turnover processes, notably is assumed to be critically important for cellular resilience longevity. However, age-associated decrease impedes elimination dysfunctional mitochondria, consequently impairing biogenesis. deleterious cascade results accumulation damaged mitochondria deterioration functions. Both excitotoxicity have been demonstrated contribute significantly pathophysiology including Alzheimer's disease (AD), Parkinson's (PD), Huntington's Disease (HD), Amyotrophic Lateral Sclerosis (ALS) Multiple (MS). Excitotoxicity, characterized by excessive glutamate signaling, initiates events involving calcium dysregulation, energy depletion, intricately linked dysfunction. Furthermore, emerging concepts surrounding underscore importance iron-dependent lipid peroxidation engagement neurodegeneration. not only discusses individual contributions ferroptosis but also emphasizes convergence with dysfunction, key driver Understanding crosstalk between oxytosis/ferroptosis, holds potential pave way mitochondrion-targeted therapeutic strategies. Such strategies, focus mitophagy, stress, emerge as promising avenues intervention.

Язык: Английский

PINK1/Parkin-mediated mitophagy in neurodegenerative diseases DOI
Jie Li, Dongming Yang, Zhiping Li

и другие.

Ageing Research Reviews, Год журнала: 2022, Номер 84, С. 101817 - 101817

Опубликована: Дек. 9, 2022

Язык: Английский

Процитировано

159

Urolithin A promotes mitophagy and suppresses NLRP3 inflammasome activation in lipopolysaccharide-induced BV2 microglial cells and MPTP-induced Parkinson's disease model DOI

Jingru Qiu,

Ye Chen,

Jing Zhuo

и другие.

Neuropharmacology, Год журнала: 2022, Номер 207, С. 108963 - 108963

Опубликована: Янв. 19, 2022

Язык: Английский

Процитировано

98

Pharmacological approaches to enhance mitochondrial biogenesis: focus on PGC-1Α, AMPK, and SIRT1 in cellular health DOI

Ahmet Alperen Palabiyik,

Esra Palabıyık

Molecular Biology Reports, Год журнала: 2025, Номер 52(1)

Опубликована: Фев. 28, 2025

Язык: Английский

Процитировано

3

Paeoniflorin: A neuroprotective monoterpenoid glycoside with promising anti-depressive properties DOI
Xiaole Wang, Sitong Feng, Yating Wang

и другие.

Phytomedicine, Год журнала: 2021, Номер 90, С. 153669 - 153669

Опубликована: Июль 22, 2021

Язык: Английский

Процитировано

85

Mitochondria targeting drugs for neurodegenerative diseases—Design, mechanism and application DOI Creative Commons
Jiajia Xu, Wei Du, Yunhe Zhao

и другие.

Acta Pharmaceutica Sinica B, Год журнала: 2022, Номер 12(6), С. 2778 - 2789

Опубликована: Март 10, 2022

Neurodegenerative diseases (NDDs) such as Alzheimer's disease (AD) and Parkinson's (PD) are a heterogeneous group of disorders characterized by progressive degeneration neurons. NDDs threaten the lives millions people worldwide regretfully remain incurable. It is well accepted that dysfunction mitochondria underlies pathogenesis NDDs. Dysfunction results in energy depletion, oxidative stress, calcium overloading, caspases activation, which dominates neuronal death Therefore, preferred target for intervention So far various mitochondria-targeting drugs have been developed delightfully some them demonstrate promising outcome, though there still obstacles targeting specificity, delivery capacity hindering development. In present review, we will elaborately address 1) strategy to design drugs, 2) rescue mechanism respective 3) how evaluate therapeutic effect. Hopefully this review provide comprehensive knowledge understanding develop more effective treatment

Язык: Английский

Процитировано

69

Mitophagy activation by rapamycin enhances mitochondrial function and cognition in 5×FAD mice DOI Creative Commons

Wenrong Zheng,

Kualiang Li,

Meihua Zhong

и другие.

Behavioural Brain Research, Год журнала: 2024, Номер 463, С. 114889 - 114889

Опубликована: Фев. 1, 2024

Alzheimer's disease (AD) is the most prevalent form of dementia, characterized by severe mitochondrial dysfunction, which an intracellular process that significantly compromised in early stages AD. Mitophagy, selective removal damaged mitochondria, a potential therapeutic strategy for Rapamycin, mammalian target rapamycin (mTOR) inhibitor, augmented autophagy and mitigated cognitive impairment. Our study revealed enhances function activating mitophagy, alleviating neuronal loss, improving dysfunction 5 ×FAD mice. Interestingly, neuroprotective effect AD were negated treatment with 3-MA, mitophagy inhibitor. Overall, our findings suggest ameliorates impairment mice via activation its downstream PINK1-Parkin pathway, aids clearance amyloid-β (Aβ) mitochondria. This reveals novel mechanism involving regulation underlying provides new insights targets However, there are still some shortcomings this topic; if we can further knock out PINK1/Parkin gene animals or use siRNA technology, confirm experimental results.

Язык: Английский

Процитировано

10

The Role of G-Protein-Coupled Receptor Kinase 4 in Modulating Mitophagy and Oxidative Stress in Cerebral Ischemia–Reperfusion Injury DOI
Jian Wang,

Diheng Gu,

Ke Jin

и другие.

NeuroMolecular Medicine, Год журнала: 2025, Номер 27(1)

Опубликована: Март 7, 2025

Язык: Английский

Процитировано

1

Berberine: an isoquinoline alkaloid targeting the oxidative stress and gut-brain axis in the models of depression DOI

Cong-Ya Chen,

Yi Zhang

European Journal of Medicinal Chemistry, Год журнала: 2025, Номер unknown, С. 117475 - 117475

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

1

Mitochondrial Abnormalities and Synaptic Damage in Huntington’s Disease: a Focus on Defective Mitophagy and Mitochondria-Targeted Therapeutics DOI

Neha Sawant,

Hallie Morton,

Sudhir Kshirsagar

и другие.

Molecular Neurobiology, Год журнала: 2021, Номер 58(12), С. 6350 - 6377

Опубликована: Сен. 14, 2021

Язык: Английский

Процитировано

42

Research progress on the pharmacological effects of berberine targeting mitochondria DOI Creative Commons
Xinyi Fang, Haoran Wu, Jiahua Wei

и другие.

Frontiers in Endocrinology, Год журнала: 2022, Номер 13

Опубликована: Авг. 11, 2022

Berberine is a natural active ingredient extracted from the rhizome of Rhizoma Coptidis , which interacts with multiple intracellular targets and exhibits wide range pharmacological activities. Previous studies have preliminarily confirmed that regulation mitochondrial activity related to various actions berberine, such as regulating blood sugar lipid inhibiting tumor progression. However, mechanism berberine’s remains be further studied. This paper summarizes molecular quality control system briefly reviews berberine in activity. It proposed mainly regulates glycolipid metabolism by respiratory chain function, promotes cell apoptosis pathway, protects cardiac function promoting mitophagy alleviate dysfunction. reveals effects perspective mitochondria provides scientific basis for application clinical treatment diseases.

Язык: Английский

Процитировано

34