Revista de la Sociedad Española del Dolor,
Год журнала:
2022,
Номер
unknown
Опубликована: Янв. 1, 2022
a
la
corrección
de
estilo
final,
composición
y
revisión
prueba
resultante
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que
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publique
en
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forma
final.Tenga
cuenta
durante
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dar
errores
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afectar
contenido
final.El
copyright
todos
los
derechos
legales
aplican
al
artículo
pertenecen
Revista
Sociedad
Española
Dolor.
Frontiers in Psychiatry,
Год журнала:
2023,
Номер
14
Опубликована: Сен. 5, 2023
Much
recent
attention
has
been
directed
toward
the
spatial
organization
of
cell
nucleus
and
manner
in
which
three-dimensional
topologically
associated
domains
transcription
factories
are
epigenetically
coordinated
to
precisely
bring
enhancers
into
close
proximity
with
promoters
control
gene
expression.
Twenty
lines
evidence
robustly
implicate
cannabinoid
exposure
accelerated
organismal
cellular
aging.
Aging
recently
shown
be
caused
by
increased
DNA
breaks.
These
breaks
rearrange
maldistribute
epigenomic
machinery
weaken
reverse
differentiation,
cause
genome-wide
demethylation,
reduce
transcription,
lead
inhibition
developmental
pathways,
contribute
progressive
loss
function
chronic
immune
stimulation
that
characterize
Both
lineage-defining
superenhancers
superanchors
them
weakened.
Cannabis
phenocopies
elements
this
process
reproduces
chromatin
breakages,
reduces
DNA,
RNA
protein
histone
synthesis,
interferes
controlling
both
modifications,
induces
general
hypomethylation,
epigenomically
disrupts
critical
boundary
cohesin
motors
create
loops.
This
pattern
widespread
interference
programs
relative
dedifferentiation
(which
is
pro-oncogenic)
reinforced
impairment
intermediate
metabolism
locks
stem
cell-like
hyper-replicative
state)
perpetuates
increases
aging
senescence
programs,
damage,
genomic
instability,
oncogenesis),
together
account
for
diverse
teratologic
carcinogenic
outcomes
reported
large
epidemiologic
studies
Europe,
USA,
elsewhere.
It
also
accounts
prominent
phenotype
observed
clinically
long-term
cannabis
use
disorder
20
characteristics
it
manifests.
Increasing
daily
use,
increasing
pregnancy,
exponential
dose-response
effects
heighten
clinical
urgency
these
findings.
Together,
findings
indicate
genotoxicity
epigenotoxicity
features
dependence
strongly
multiomics
investigations
genome-epigenome-transcriptome-metabolome,
conformation,
3D
nuclear
architecture.
Considering
well-established
relationships,
diversity
cannabinoids,
multigenerational
nature
implications,
great
caution
warranted
community
penetration.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Янв. 30, 2023
Abstract
The
gut
microbiota
plays
a
pivotal
role
in
health
and
disease.
use
of
probiotics
as
microbiota-targeted
therapies
is
promising
strategy
to
improve
host
health.
However,
dynamic
molecular
mechanisms
are
often
not
elucidated,
especially
when
targeting
the
small
intestinal
microbiota.
Here,
we
show
that
supplementation
probiotic
formula
(Ecologic®825)
adult
human
ileostoma
counteracts
growth
Enterococcaceae
Enterobacteriaceae
reduces
ethanol
production,
leading
major
changes
nutrient
utilization
resistance
perturbations.
observed
alterations
coincided
with
an
initial
increase
lactate
production
decrease
pH
by
probiotics,
followed
sharp
levels
butyrate
propionate.
Additionally,
increased
multiple
N
-acyl
amino
acids
was
detected
stoma
samples
supplemented
formula.
Overall,
this
study
shows
how
network
theory
can
be
used
current
or
identify
novel
therapies.
outcome
may
help
further
understand
reported
effects
these
on
host.
Revista de la Sociedad Española del Dolor,
Год журнала:
2022,
Номер
unknown
Опубликована: Янв. 1, 2022
a
la
corrección
de
estilo
final,
composición
y
revisión
prueba
resultante
antes
que
se
publique
en
su
forma
final.Tenga
cuenta
durante
el
proceso
producción
pueden
dar
errores
lo
podría
afectar
contenido
final.El
copyright
todos
los
derechos
legales
aplican
al
artículo
pertenecen
Revista
Sociedad
Española
Dolor.