Dietary Supplements for Weight Loss and Drug Interactions DOI Creative Commons
Francisco Rivas García, Jorge Sierra, Maria Isabel Valverde‐Merino

и другие.

Pharmaceuticals, Год журнала: 2024, Номер 17(12), С. 1658 - 1658

Опубликована: Дек. 9, 2024

Food supplements are used for a variety of purposes, one which is weight reduction. As excess long-term condition, some expected to be long periods time. The use these dietary makes it highly likely that they will combined with medications, increasing the risk food supplement–drug interactions, not always known or disclosed, and can lead serious health problems, as has been observed. This article discusses compounds reduction (green tea extract, Garcinia cambogia, chitosan, quercetin resveratrol) interactions may cause drugs such as: dextromethorphan, buspirone, diclofenac, irinotecan, 5-fluorouracil, cytochrome P450 inducers inhibitors, statins, orlistat, warfarina, acenocoumarol, fluoxetine, valproate, quetiapine, carbamazepine. information useful healthcare professionals detect intervene on ensure optimization therapy patient safety.

Язык: Английский

Dietary “Beigeing” Fat Contains More Phosphatidylserine and Enhances Mitochondrial Function While Counteracting Obesity DOI Creative Commons
Yanbing Zhou,

Defeng Ling,

Liyi Wang

и другие.

Research, Год журнала: 2024, Номер 7

Опубликована: Янв. 1, 2024

Activation of mitochondrial function and heat production in adipose tissue by the modification dietary fat is a promising strategy against obesity. However, as an important source lipids for ketogenic daily diets, fats extracted from different sites was largely unknown. In this study, we illustrated tissues with “beigeing” properties diet identified lipid profiles that facilitate energy expenditure. We found anti-obesity effect diets potentiated using [porcine subcutaneous (SAT)] major energy-providing ingredient. Through lipidomic analyses, phosphatidylserine (PS) functional activating thermogenesis tissue. Moreover, vivo studies showed PS induces alleviates diet-induced obesity mice. vitro promotes UCP1 expression lipolysis adipocytes. Mechanistically, promoted adipocytes via ADCY3-cAMP-PKA-PGC1α pathway. addition, PS-PGC1a binding may affect stability PGC1α protein, which further augments PS-induced thermogenesis. These results demonstrated efficacy SAT diminishing accumulation underlying molecular mechanism enhancing function. Thus, our findings suggest fat, provides more beneficial contribute to improvement function, including PS, become novel, nonpharmacological therapy increase expenditure counteract its related diseases.

Язык: Английский

Процитировано

2
The Chinese herbal medicine Dai-Zong-Fang promotes browning of white adipocytes in vivo and in vitro by activating PKA pathway to ameliorate obesity DOI Creative Commons
Jing Xu, Liwei Zhang,

Hui Feng

и другие.

Frontiers in Pharmacology, Год журнала: 2023, Номер 14

Опубликована: Май 10, 2023

Introduction: The global prevalence of obesity is rising rapidly. Conversion white adipose tissue (WAT) into beige with heat-consuming characteristics, i.e., WAT browning, effectively inhibits obesity. Dai-Zong-Fang (DZF), a traditional Chinese medicine formula, has long been used to treat metabolic syndrome and This study aimed explore the pharmacological mechanism DZF against Methods: In vivo , C57BL/6J mice were fed high-fat diets establish diet-induced obese (DIO) model. (0.40 g/kg 0.20 g/kg) metformin (0.15 g/kg, positive control drug) as intervention drugs for six weeks, respectively. effects on body size, blood glucose lipid level, structure morphology adipocytes browning inguinal (iWAT) in DIO observed. vitro mature 3T3-L1 Concentrations (0.8 mg/mL 0.4 mg/mL) selected according Cell Counting Kit-8 (CCK8). After 2d intervention, droplet was observed by BODIPY493/503 staining, mitochondria number mito-tracker Green staining. H-89 dihydrochloride, PKA inhibitor, observe change markers′ expression. expression levels markers UCP1 PGC-1α key molecules pathway detected . Results: compared vehicle group, 0.40 significantly reduced from weight, abdomen circumference, Lee′s index, WAT/body weight ( p < 0.01 or 0.001). also fasting (FBG), serum triglycerides (TG), total cholesterol (TC), low-density lipoprotein (LDL-C) iWAT′s after intervention. HE-staining, droplets became smaller, increased. mitochondrial remodeled under electron microscope. UCP1, elevated iWAT RT-qPCR 0.05 vitro, 0.8 increased PGC-1α, PKA, pCREB 0.01). contrast, reversed adding inhibitor dihydrochloride. Conclusion: can promote activating pathway, thereby promoting WAT, attenuating obesity, reducing obesity-related metabolism abnormalities, indicating that potential be an anti-obesity drug benefit patients.

Язык: Английский

Процитировано

5
Acteoside improves adipocyte browning by CDK6-mediated mTORC1-TFEB pathway DOI
Yunxia Sun,

Xintao Ni,

Siyao Cheng

и другие.

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, Год журнала: 2023, Номер 1868(9), С. 159364 - 159364

Опубликована: Июль 9, 2023

Язык: Английский

Процитировано

5
Ling-gui-zhu-gan promotes adipocytes browning via targeting the miR-27b/PRDM16 pathway in 3T3-L1 cells DOI Creative Commons

Zimengwei Ye,

Yi Zhao,

Yanjing Cui

и другие.

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Авг. 14, 2024

Introduction: Obesity, a global epidemic, is caused by an imbalance between energy intake and expenditure. The induction of white adipose browning to increase heat production has emerged as potential effective strategy address obesity. Ling-gui-zhu-gan (LGZG), traditional Chinese medicine formula, been proved achieve promising results combat obesity related metabolic diseases, yet the mechanisms remain largely unexplored. This study aimed elucidate anti-obesity properties LGZG investigating its effect on 3T3-L1 adipocytes. Methods: LGZG-containing serum obtained oral administration animals was added adipocytes simulate in vivo conditions. Results: showed that 49 compounds were identified UHPLC-Q-Orbitrap HRMS, including such atractylenolides polyporenic acid C, etc. alleviated lipid accumulation decreased both intracellular extracellular triglyceride contents dose-dependent manner. reduction accompanied enhanced mitochondrial respiratory function. Mechanistically, led decrease miR-27b expression mRNA protein levels browning-related markers, UCP1, PRDM16, PGC-1α, PPARγ, CTBP1, CTBP2. Further investigation using mimic transfection confirmed miR-27b/PRDM16 pathway might be mechanism which promotes Discussion: These underscore therapeutic addressing associated disorders through promotion browning.

Язык: Английский

Процитировано

1
Dietary Supplements for Weight Loss and Drug Interactions DOI Creative Commons
Francisco Rivas García, Jorge Sierra, Maria Isabel Valverde‐Merino

и другие.

Pharmaceuticals, Год журнала: 2024, Номер 17(12), С. 1658 - 1658

Опубликована: Дек. 9, 2024

Food supplements are used for a variety of purposes, one which is weight reduction. As excess long-term condition, some expected to be long periods time. The use these dietary makes it highly likely that they will combined with medications, increasing the risk food supplement–drug interactions, not always known or disclosed, and can lead serious health problems, as has been observed. This article discusses compounds reduction (green tea extract, Garcinia cambogia, chitosan, quercetin resveratrol) interactions may cause drugs such as: dextromethorphan, buspirone, diclofenac, irinotecan, 5-fluorouracil, cytochrome P450 inducers inhibitors, statins, orlistat, warfarina, acenocoumarol, fluoxetine, valproate, quetiapine, carbamazepine. information useful healthcare professionals detect intervene on ensure optimization therapy patient safety.

Язык: Английский

Процитировано

1