Phytotherapy Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 23, 2025
ABSTRACT
Lung
cancer
remains
one
of
the
most
widespread
and
deadliest
malignant
tumors
globally,
with
a
particularly
high
mortality
rate
among
all
cancers.
Recently,
immunotherapy,
immune
checkpoint
inhibitors
(ICIs),
has
emerged
as
crucial
treatment
strategy
for
lung
patients,
following
surgical
intervention,
radiotherapy,
chemotherapy,
targeted
drug
therapies.
However,
therapeutic
limitations
are
caused
owing
to
their
low
response
undesirable
side
effects
such
immune‐related
pneumonitis.
Therefore,
developing
new
strategies
improve
efficacy
ICIs
while
minimizing
adverse
events
will
be
immunotherapy.
The
tumor
microenvironment
plays
significant
role
in
success
immunosuppressive
characteristics
major
obstacles
poor
immunotherapeutic
effect.
Phytochemicals,
naturally
occurring
compounds
plants,
have
shown
promise
enhancing
immunotherapy
by
remodeling
microenvironment,
offering
potential
increase
ICIs.
this
review
summarizes
associated
mechanisms
phytochemicals
cancer.
Additionally,
focus
on
synergistic
combining
ICIs,
aiming
anticancer
reduce
effects,
which
may
hopefully
offer
novel
overcome
current
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(19), С. 15016 - 15016
Опубликована: Окт. 9, 2023
Autophagy
is
a
catabolic
process
that
essential
to
the
maintenance
of
homeostasis
through
cellular
recycling
damaged
organelles
or
misfolded
proteins,
which
sustains
energy
balance.
Additionally,
autophagy
plays
dual
role
in
modulating
development
and
progression
cancer
inducing
survival
strategy
tumoral
cells.
Programmed
cell
death-ligand
1
(PD-L1)
modulates
immune
response
responsible
for
maintaining
self-tolerance.
Because
tumor
cells
exploit
PD-L1-PD-1
interaction
subvert
response,
immunotherapy
has
been
developed
based
on
use
PD-L1-blocking
antibodies.
Recent
evidence
suggested
bidirectional
regulation
between
PD-L1
molecule
expression
Moreover,
research
into
intrinsic
properties
highlighted
new
functions
are
advantageous
The
relationship
complex
still
not
fully
understood;
its
effects
can
be
context-dependent
might
differ
This
review
refines
our
understanding
non-immune
potential
influence
autophagy,
how
these
could
allow
cells,
what
this
means
efficacy
anti-PD-L1
therapeutic
strategies.
Chemical Biology & Drug Design,
Год журнала:
2025,
Номер
105(2)
Опубликована: Фев. 1, 2025
ABSTRACT
Globally,
non‐small
cell
lung
cancer
(NSCLC)
is
the
primary
cause
of
cancer‐related
deaths.
Rutecarpine
(RUT),
a
quinazolinocarboline
alkaloid
that
naturally
occurring
and
present
in
Chinese
medicinal
herbs,
has
been
shown
to
have
anticancer
properties
several
lines.
However,
specific
antitumor
mechanisms
RUT
NSCLC
remain
unclear.
This
study
demonstrates
induces
apoptosis
significantly
reduces
viability
effect
achieved
by
stimulating
intracellular
ROS
production,
leading
mitochondrial
dysfunction.
The
decreased
observed
with
treatment
attributed
elimination
through
suppression
N‐acetylcysteine
(NAC).
Furthermore,
therapy
elevated
production
CXCL10
CCL5
lines
markedly
activated
STING
pathway
cells.
Mechanistically,
substantially
levels
PD‐L1
protein
Notably,
vivo
experiments
demonstrated
inhibits
mouse
tumor
growth
mice,
exhibiting
anti‐tumor
activity
elevating
CD8
+
T
These
findings
strongly
support
as
promising
anti‐cancer
drug
for
NSCLC.
Phytotherapy Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 23, 2025
ABSTRACT
Lung
cancer
remains
one
of
the
most
widespread
and
deadliest
malignant
tumors
globally,
with
a
particularly
high
mortality
rate
among
all
cancers.
Recently,
immunotherapy,
immune
checkpoint
inhibitors
(ICIs),
has
emerged
as
crucial
treatment
strategy
for
lung
patients,
following
surgical
intervention,
radiotherapy,
chemotherapy,
targeted
drug
therapies.
However,
therapeutic
limitations
are
caused
owing
to
their
low
response
undesirable
side
effects
such
immune‐related
pneumonitis.
Therefore,
developing
new
strategies
improve
efficacy
ICIs
while
minimizing
adverse
events
will
be
immunotherapy.
The
tumor
microenvironment
plays
significant
role
in
success
immunosuppressive
characteristics
major
obstacles
poor
immunotherapeutic
effect.
Phytochemicals,
naturally
occurring
compounds
plants,
have
shown
promise
enhancing
immunotherapy
by
remodeling
microenvironment,
offering
potential
increase
ICIs.
this
review
summarizes
associated
mechanisms
phytochemicals
cancer.
Additionally,
focus
on
synergistic
combining
ICIs,
aiming
anticancer
reduce
effects,
which
may
hopefully
offer
novel
overcome
current
