Passivation protein-adhesion platform promoting stent reendothelialization using two-electron-assisted oxidation of polyphenols

Biomaterials, Год журнала: 2023, Номер 305, С. 122423 - 122423

Опубликована: Дек. 16, 2023

Язык: Английский

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Construction of phenolic acids grafted chitosan bioactive microspheres to reduce oxidation and iron absorption in meat digestion

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 265, С. 130897 - 130897

Опубликована: Март 14, 2024

Язык: Английский

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Nanoparticles constructed from natural polyphenols are used in acute kidney injury

Journal of Materials Chemistry B, Год журнала: 2024, Номер 12(36), С. 8883 - 8896

Опубликована: Янв. 1, 2024

Acute kidney injury (AKI) is a severe clinical syndrome characterized by rapid deterioration of renal function caused variety pathogeneses.

Язык: Английский

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Nano-curcumin formulations for targeted therapy of colorectal cancer

Journal of Drug Delivery Science and Technology, Год журнала: 2023, Номер 88, С. 104943 - 104943

Опубликована: Сен. 9, 2023

Язык: Английский

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Protective Effects of Plant-Derived Compounds Against Traumatic Brain Injury

Molecular Neurobiology, Год журнала: 2024, Номер 61(10), С. 7732 - 7750

Опубликована: Март 1, 2024

Inflammation in the nervous system is one of key features many neurodegenerative diseases. It increasingly being identified as a critical pathophysiological primitive mechanism associated with chronic diseases following traumatic brain injury (TBI). Phytochemicals have wide range clinical properties due to their antioxidant and anti-inflammatory effects. Currently, there are few drugs available for treatment other than symptomatic relief. Numerous studies shown that plant-derived compounds, particular polyphenols, protect against various safe consumption. Polyphenols exert protective effects on TBI via restoration nuclear factor kappa B (NF-κB), toll-like receptor-4 (TLR4), Nod-like receptor family proteins (NLRPs) pathways. In addition, these phytochemicals derivatives upregulate phosphatidylinositol-3-Kinase/Protein Kinase (PI3K/AKT) erythroid 2-related 2 (Nrf2) pathways, which functions modulating symptoms. There supporting evidence medicinal plants different models, though future trials needed clarify precise mechanisms polyphenolic compounds TBI.

Язык: Английский

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Effect of polyphenols against complications of COVID-19: current evidence and potential efficacy

Pharmacological Reports, Год журнала: 2024, Номер 76(2), С. 307 - 327

Опубликована: Март 18, 2024

Язык: Английский

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The role of natural products as PCSK9 modulators: A review

Phytotherapy Research, Год журнала: 2024, Номер 38(8), С. 4081 - 4098

Опубликована: Июнь 20, 2024

Abstract A variety of mechanisms and drugs have been shown to attenuate cardiovascular disease (CVD) onset and/or progression. Recent researchers identified a potential role proprotein convertase subtilisin/kexin type 9 (PCSK9) in modulating lipid metabolism reducing plasma low density lipoprotein (LDL) levels. PCSK9 is the central protein LDL cholesterol (LDL‐C) owing its major function receptor (LDLR) degradation. Due close correlation with levels, many vivo vitro investigations are currently underway studying physiological PCSK9. Furthermore, studies actively investigating various compounds that influence associated‐disorders their associated diseases. inhibitors significant impact prevention emerging Natural products can effectively be used as control levels through mechanisms. In this review, we evaluate phytochemicals natural regulation PCSK9, ability prevent Moreover, describe action, which not date delineated.

Язык: Английский

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Neutrophil extracellular traps and cardiovascular disease: Associations and potential therapeutic approaches

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 180, С. 117476 - 117476

Опубликована: Окт. 1, 2024

Язык: Английский

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Modulatory properties of curcumin in cancer: A narrative review on the role of interferons

Phytotherapy Research, Год журнала: 2023, Номер 37(3), С. 1003 - 1014

Опубликована: Фев. 6, 2023

The immune network is an effective of cell types and chemical compounds established to maintain the body's homeostasis from foreign threats prevent risk a wide range diseases; hence, its proper functioning balance are essential. A dysfunctional system can contribute various disorders, including cancer. Therefore, there has been considerable interest in molecules that modulate network. Curcumin, active ingredient turmeric, one these herbal remedies with many beneficial effects, modulation immunity. Curcumin managing chronic inflammatory conditions, improving brain function, lowering cardiovascular disease risk, prevention management dementia, aging. Several clinical studies have supported this evidence, suggesting curcumin immunomodulatory anti-inflammatory function; nevertheless, mechanism action still not clear. In current review, we aim explore modulatory function through interferons cancers.

Язык: Английский

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Polyphenols and Cardiometabolic Health: Knowledge and Concern among Romanian People

Nutrients, Год журнала: 2023, Номер 15(10), С. 2281 - 2281

Опубликована: Май 12, 2023

The cardiometabolic health of the population is a crucial indicator public health, considering significant impact cardiovascular disease (CVD) and diabetes on global mortality. Determining population's knowledge predictors these pathologies essential in developing effective educational clinical strategies for prevention management risk (CMR). Polyphenols are natural compounds with multitude beneficial effects health. This study explored current knowledge, understanding, awareness CMR, benefits polyphenols among Romanians, how sociodemographic characteristics influence this aspect. Five hundred forty-six subjects responded anonymously to an online questionnaire designed assess their knowledge. data were collected analyzed based gender, age, education level, BMI status. Most respondents expressed concern great or very extent about (78%) food (60%), differences (

Язык: Английский

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