Frontiers in Molecular Biosciences,
Год журнала:
2025,
Номер
12
Опубликована: Фев. 6, 2025
HOXC13
antisense
RNA
(HOXC13-AS,
also
known
as
HOXC-AS5)
is
a
long
non-coding
that
expressed
abnormally
in
various
types
of
tumors
and
closely
related
to
clinical
staging,
pathological
features,
patient
survival.
HOXC13-AS
involved
the
occurrence
development
tumors,
affecting
cell
proliferation,
migration,
invasion,
epithelial-mesenchymal
transition,
tumor
growth.
This
review
summarizes
significance
biomarker
for
human
diagnosis
prognosis
outlines
function
molecular
regulation
mechanism
cancer,
including
nasopharyngeal
carcinoma,
breast
oral
squamous
glioma,
cervical
cancer.
Overall,
this
emphasizes
potential
predictive
therapeutic
target,
paving
way
its
application.
Abstract
Gastrointestinal
cancer
(GIC)
is
the
most
prevalent
and
highly
metastatic
malignant
tumor
has
a
significant
impact
on
mortality
rates.
Nevertheless,
swift
advancement
of
contemporary
technology
not
seamlessly
aligned
with
evolution
detection
methodologies,
resulting
in
deficit
innovative
efficient
clinical
assays
for
GIC.
Given
that
exosomes
are
preferentially
released
by
myriad
cellular
entities,
predominantly
originating
from
neoplastic
cells,
this
confers
composition
enriched
cancer-specific
constituents.
Furthermore,
exhibit
ubiquitous
presence
across
diverse
biological
fluids,
endowing
them
inherent
advantages
non-invasiveness,
real-time
monitoring,
specificity.
The
unparalleled
render
as
an
ideal
liquid
biopsy
biomarker
early
diagnosis,
prognosticating
potential
development
GIC
metastasis.
In
review,
we
summarized
latest
research
progress
possible
targets
cancer-derived
(CDEs)
emphasis
mechanisms
exosome
promoting
metastasis,
highlighting
roles
CDEs
treatment
Drug Development Research,
Год журнала:
2025,
Номер
86(1)
Опубликована: Янв. 20, 2025
ABSTRACT
Chemotherapy
is
an
effective
treatment
for
gastric
cancer.
However,
many
patients
develop
resistance
to
chemotherapeutic
agents
during
clinical
treatment.
LncRNA
CCAT1
has
recently
been
shown
influence
cellular
specific
drugs,
but
its
role
in
cancer
remains
underexplored.
This
study
aims
investigate
the
of
cisplatin
cells
and
potential
underlying
mechanisms.
Gastric
cell
lines
with
acquired
were
established.
The
expression
was
assessed
both
cisplatin‐sensitive
cisplatin‐resistant
AGS
lines.
knocked
down
AGS/DDP
cells,
changes
IC50
values
measured
using
Cell
Counting
Kit‐8
(CCK‐8)
assay.
Apoptosis
evaluated
by
flow
cytometry.
Additionally,
Western
blotting
employed
measure
levels
PI3K/AKT/mTOR
signaling
pathway
proteins
apoptosis‐related
interference
control
groups.
RT‐qPCR
results
indicated
that
significantly
elevated
compared
non‐resistant
cells.
Similarly,
CCK‐8
assay
demonstrated
knocking
resistant
increased
their
sensitivity
Flow
cytometry
blot
further
confirmed
silencing
promoted
apoptosis
these
higher
sensitive
counterparts,
resulted
reduced
proteins.
In
conclusion,
above
studies
induced
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(21), С. 12893 - 12893
Опубликована: Окт. 25, 2022
Ovarian
cancer
is
one
of
the
most
dangerous
gynecologic
cancers
worldwide,
showing
a
high
fatality
rate
and
recurrence
due
to
diagnosis
at
an
advanced
stage
disease
occurrence
chemoresistance,
which
weakens
therapeutic
effects
chemotherapeutic
treatments.
In
fact,
although
paclitaxel
platinum-based
drugs
(carboplatin
or
cisplatin)
are
widely
used
alone
in
combination
treat
ovarian
cancer,
chemoresistance
significantly
reduces
these
drugs.
Metformin
hypoglycemic
agent
that
commonly
for
treatment
type
2
diabetes
mellitus
non-alcoholic
fatty
liver
disease.
However,
this
drug
also
shows
anti-tumor
activity,
reducing
risk
chemoresistance.
This
review
analyzes
current
literature
regarding
role
metformin
investigates
what
currently
known
about
its
platinum
resistance
restore
sensitivity
Pharmacological Research,
Год журнала:
2023,
Номер
190, С. 106732 - 106732
Опубликована: Март 15, 2023
High
mobility
group
A
2
(HMGA2)
is
a
protein
that
modulates
the
structure
of
chromatin
in
nucleus.
Importantly,
aberrant
expression
HMGA2
occurs
during
carcinogenesis,
and
this
an
upstream
mediator
cancer
hallmarks
including
evasion
apoptosis,
proliferation,
invasion,
metastasis,
therapy
resistance.
targets
critical
signaling
pathways
such
as
Wnt/β-catenin
mTOR
cells.
Therefore,
suppression
function
notably
decreases
progression
improves
outcome
patients.
As
mainly
oncogenic,
targeting
by
non-coding
RNAs
(ncRNAs)
crucial
to
take
into
consideration
since
it
affects
function.
MicroRNAs
(miRNAs)
belong
ncRNAs
are
master
regulators
vital
cell
processes,
which
affect
all
aspects
hallmarks.
Long
(lncRNAs)
circular
(circRNAs),
other
members
ncRNAs,
mediators
miRNAs.
The
current
review
intends
discuss
importance
miRNA/HMGA2
axis
modulation
various
types
cancer,
mentions
lncRNAs
circRNAs,
regulate
mediators.
Finally,
we
effect
miRNAs
interactions
on
response
cells
therapy.
Regarding
role
regulation
cells,
considering
confirmed
interaction
between
one
miRNAs,
promising
could
be
subject
future
clinical
trial
experiments.
International Journal of Oncology,
Год журнала:
2024,
Номер
64(5)
Опубликована: Март 13, 2024
Since
its
discovery,
the
role
of
transcription
factor,
signal
transducer
and
activator
3
(STAT3),
in
both
normal
physiology
pathology
numerous
diseases,
including
cancer,
has
been
extensively
studied.
STAT3
is
aberrantly
activated
different
types
fulfilling
a
critical
cancer
progression.
The
biological
process,
epithelial‑mesenchymal
transition
(EMT),
indispensable
for
embryonic
morphogenesis.
During
development
EMT
hijacked
to
confer
motility,
tumor
cell
stemness,
drug
resistance
adaptation
changes
microenvironment.
aim
present
review
was
outline
recent
advances
knowledge
EMT,
which
may
contribute
understanding
function
various
cancer.
Delineating
underlying
mechanisms
associated
with
STAT3‑EMT
signaling
axis
generate
novel
diagnostic
therapeutic
options
treatment.
Cell Death Discovery,
Год журнала:
2024,
Номер
10(1)
Опубликована: Фев. 14, 2024
Long
noncoding
RNAs
(lncRNAs)
are
a
group
of
with
transcript
lengths
>200
nucleotides.
Mounting
evidence
suggests
that
lncRNAs
closely
associated
tumorigenesis.
LncRNA
H19
(H19)
was
the
first
lncRNA
to
function
as
an
oncogene
in
many
malignant
tumors.
Apart
from
established
role
promoting
cell
growth,
proliferation,
invasion,
migration,
epithelial-mesenchymal
transition
(EMT),
and
metastasis,
it
has
been
recently
discovered
also
inhibits
programmed
death
(PCD)
cancer
cells.
In
this
review,
we
summarize
mechanisms
by
which
regulates
PCD
cells
through
various
signaling
pathways,
molecular
mechanisms,
epigenetic
modifications.
Wnt/β-catenin
pathway
PI3K-Akt-mTOR
pathway.
It
acts
competitive
endogenous
RNA
(ceRNA)
regulation.
The
interaction
between
RNA-binding
proteins
(RBP)
apoptosis
cancer.
Moreover,
modifications,
including
DNA
methylation
histone
involved
H19-associated
conclusion,
via
chemoresistance,
highlighting
promising
research
significance
therapeutic
target.
We
hope
our
study
will
contribute
broader
understanding
development
treatment.
Long
non-coding
RNA
(lncRNA)
H19
has
gained
significant
recognition
as
a
pivotal
contributor
to
the
initiation
and
advancement
of
gynecologic
cancers,
encompassing
ovarian,
endometrial,
cervical,
breast
cancers.
exhibits
complex
array
mechanisms,
demonstrating
dualistic
effects
on
tumorigenesis
it
can
function
both
an
oncogene
tumor
suppressor,
contingent
upon
specific
context
type
cancer
being
investigated.
In
ovarian
cancer,
promotes
growth,
metastasis,
chemoresistance
through
modulation
key
signaling
pathways
interaction
with
microRNAs.
Conversely,
in
endometrial
acts
suppressor
by
inhibiting
proliferation,
inducing
apoptosis,
regulating
epithelial-mesenchymal
transition.
Additionally,
been
implicated
cervical
where
influences
cell
invasion,
immune
evasion.
Moreover,
potential
diagnostic
prognostic
biomarker
for
its
expression
levels
correlating
clinical
parameters
patient
outcomes.
Understanding
functional
roles
cancers
is
crucial
development
targeted
therapeutic
strategies
personalized
treatment
approaches.
Further
investigation
into
intricate
molecular
mechanisms
underlying
H19's
involvement
malignancies
warranted
fully
unravel
implications.
This
review
aims
elucidate
various
malignancies.
Journal of Translational Medicine,
Год журнала:
2024,
Номер
22(1)
Опубликована: Май 27, 2024
Abstract
Cancer
cachexia
(CC)
is
a
debilitating
syndrome
that
affects
50–80%
of
cancer
patients,
varying
in
incidence
by
type
and
significantly
diminishing
their
quality
life.
This
multifactorial
characterized
muscle
fat
loss,
systemic
inflammation,
metabolic
imbalance.
Extracellular
vesicles
(EVs),
including
exosomes
microvesicles,
play
crucial
role
the
progression
CC.
These
vesicles,
produced
cells
others
within
tumor
environment,
facilitate
intercellular
communication
transferring
proteins,
lipids,
nucleic
acids.
A
comprehensive
review
literature
from
databases
such
as
PubMed,
Scopus,
Web
Science
reveals
insights
into
formation,
release,
uptake
EVs
CC,
underscoring
potential
diagnostic
prognostic
biomarkers.
The
also
explores
therapeutic
strategies
targeting
EVs,
which
include
modifying
release
content,
utilizing
them
for
drug
delivery,
genetically
altering
contents,
inhibiting
key
pathways.
Understanding
CC
opens
new
avenues
approaches,
potentially
mitigating
syndrome’s
impact
on
patient
survival
