Frontiers in Molecular Biosciences,
Год журнала:
2025,
Номер
12
Опубликована: Фев. 6, 2025
HOXC13
antisense
RNA
(HOXC13-AS,
also
known
as
HOXC-AS5)
is
a
long
non-coding
that
expressed
abnormally
in
various
types
of
tumors
and
closely
related
to
clinical
staging,
pathological
features,
patient
survival.
HOXC13-AS
involved
the
occurrence
development
tumors,
affecting
cell
proliferation,
migration,
invasion,
epithelial-mesenchymal
transition,
tumor
growth.
This
review
summarizes
significance
biomarker
for
human
diagnosis
prognosis
outlines
function
molecular
regulation
mechanism
cancer,
including
nasopharyngeal
carcinoma,
breast
oral
squamous
glioma,
cervical
cancer.
Overall,
this
emphasizes
potential
predictive
therapeutic
target,
paving
way
its
application.
Asia-Pacific Journal of Oncology,
Год журнала:
2025,
Номер
unknown, С. 9 - 17
Опубликована: Янв. 14, 2025
Cancer
grades
among
the
deadliest
diseases,
globally
causing
death
of
a
over
million
people
each
year.
Early
diagnosis
has
been
considered
ideal
for
efficient
treatment
as
during
later
stages
chances
become
limited.
However,
gold
standard
tissue
biopsy
various
limitation
instance,
late-stage
and
its
intrusive
operation
making
it
unfit
repeated
sampling.
Scientists
are
passionately
looking
new
technologies
techniques
cancer
prognosis.
Liquid
emerged
diagnostic
prognostic
tool
cancer,
that
relies
on
body
fluids
to
identify
biomarkers
cancer.
It
offers
advantages
like
non-invasive
operation,
timely
detection,
amenable
sampling,
covers
tumor
heterogeneity.
Wide
attention
garnered
by
liquid
is
undergoing
rapid
progress
in
list
target
biomarkers.
The
most
common
circulating
cells,
DNA,
exosomes,
educated
platelets,
non-coding
RNAs
(miRNA,
lncRNA
etc.).
Each
these
have
unique
advantages,
indeed
technology
future
with
clinical
utility.
In
this
article,
we
tried
provide
thorough
introduction
markers,
highlighted
deployed
biopsy,
briefly
overview
their
implications
indispensable
entities
diverse
types
Moreover,
discussed
prospects
revolutionary
realm
treatment.
Frontiers in Cardiovascular Medicine,
Год журнала:
2025,
Номер
12
Опубликована: Янв. 17, 2025
Calcific
aortic
valve
disease
(CAVD)
is
a
common
cardiovascular
condition
in
the
elderly
population.
The
valve,
influenced
by
factors
such
as
endothelial
dysfunction,
inflammation,
oxidative
stress,
lipid
metabolism
disorders,
calcium
deposition,
and
extracellular
matrix
remodeling,
undergoes
fibrosis
calcification,
ultimately
leading
to
stenosis.
In
recent
years,
long
non-coding
RNAs
(lncRNAs)
have
emerged
significant
regulators
of
gene
expression,
playing
crucial
roles
occurrence
progression
various
diseases.
Research
has
shown
that
lncRNAs
participate
pathological
process
underlying
CAVD
regulating
osteogenic
differentiation
inflammatory
response
interstitial
cells.
Specifically,
lncRNAs,
H19,
MALAT1,
TUG1,
are
closely
associated
with
CAVD.
Some
can
act
miRNA
sponges,
form
complex
regulatory
networks,
modulate
expression
calcification-related
genes.
brief,
this
review
discusses
mechanisms
potential
therapeutic
targets
Frontiers in Molecular Biosciences,
Год журнала:
2025,
Номер
12
Опубликована: Фев. 6, 2025
HOXC13
antisense
RNA
(HOXC13-AS,
also
known
as
HOXC-AS5)
is
a
long
non-coding
that
expressed
abnormally
in
various
types
of
tumors
and
closely
related
to
clinical
staging,
pathological
features,
patient
survival.
HOXC13-AS
involved
the
occurrence
development
tumors,
affecting
cell
proliferation,
migration,
invasion,
epithelial-mesenchymal
transition,
tumor
growth.
This
review
summarizes
significance
biomarker
for
human
diagnosis
prognosis
outlines
function
molecular
regulation
mechanism
cancer,
including
nasopharyngeal
carcinoma,
breast
oral
squamous
glioma,
cervical
cancer.
Overall,
this
emphasizes
potential
predictive
therapeutic
target,
paving
way
its
application.
