Outpatient glucocorticoid use and COVID-19 outcomes: a population-based study

Inflammopharmacology, Год журнала: 2024, Номер unknown

Опубликована: Май 2, 2024

Abstract Introduction Owing to controversy information surrounds effect of glucocorticoids on the evolution COVID-19, we evaluate effects outpatient glucocorticoid use severity and progression COVID-19 risk infection analyse window exposure dose. Methods We conducted a population-based case − control study, involving 4 substudies: (i) Hospitalisation; (ii) Mortality, using subjects hospitalised with PCR + as cases without controls; (iii) Progression, including (hospitalised versus non-hospitalised); (iv) Susceptibility, all . Adjusted odds ratios (ORa) their 95% confidence intervals (95% CI) were calculated. Results The was associated an increased hospitalisation (aOR 1.79; CI 1.56–2.05), mortality 2.30; 1.68–3.15), 1.69; 1.43–2.00) susceptibility 1.29, 1.19–1.41). Furthermore, observed be greater at higher doses closer that drug approached outcome date, almost fourfold increase in among users previous month 3.85; 2.63–5.62). Conclusions According results this real-world data should considered making decisions about intrahospital treatment.

Язык: Английский

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Investigating the relationship between the immune response and the severity of COVID-19: a large-cohort retrospective study

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Июнь 21, 2024

Abstract The COVID-19 pandemic has left an indelible mark globally, presenting numerous challenges to public health. This crisis, while disruptive and impactful, provided a unique opportunity gather precious clinical data extensively. In this observational, case-control study, we utilized collected at the Azienda Sanitaria Universitaria Friuli Centrale, Italy, comprehensively characterize immuno-inflammatory features in patients. Specifically, employed multicolor flow cytometry, cytokine assays, inflammatory biomarkers elucidate interplay between infectious agent host’s immune status. We characterized profiles within first 72 hours of hospital admission, stratified by age, disease severity, time elapsed since symptom onset. Our findings indicate that patients admitted shortly after onset exhibit distinct pattern compared those who arrive later, more active response heightened activity, but lower markers tissue damage. used univariate multivariate logistic regression models identify informative for outcome severity. Predictors incorporating significantly outperformed standard baselines, identifying up 59% with positive outcomes maintaining false omission rate as low 4%. Overall, our study sheds light on aspects observed prior vaccination, providing insights guiding management first-time infections novel virus.

Язык: Английский

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Impact of diabetes on COVID-19 and glucocorticoids on patients with COVID-19 and diabetes during the Omicron variant epidemic: a multicenter retrospective cohort study in South China

BMC Infectious Diseases, Год журнала: 2024, Номер 24(1)

Опубликована: Июль 18, 2024

Abstract Background To explore the impact of diabetes on clinical features and prognosis COVID-19 assess influence glucocorticoid use patients with diabetes. Methods This retrospective multicenter cohort study included admitted between December 2022 January 2023. The were grouped according to use. primary outcome was in-hospital mortality. Results Among 400 data, 109 (27.3%) had inflammatory cytokines higher in diabetes, manifested by IL-6 (25.33 vs. 11.29 ng/L, p = 0.011), CRP (26.55 8.62 mg/L, 0.003), PCT (0.07 0.04 ng/ml, 0.010), while CD4 + (319 506 /mL, 0.004) CD8 (141 261 < 0.001) T lymphocytes lower. overall mortality rate hospitalized 13.46%. diabetic who received glucocorticoids those did not receive a similar (15.00% 11.39%, 0.591). Conclusions Patients are more likely experience hyperinflammatory response cell reduction, especially severe/critical disease. Glucocorticoid associated Still, should be used cautiously COVID-19.

Язык: Английский

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Ultraselective, Ultrahigh Resolution 1D TOCSY

Chemistry - Methods, Год журнала: 2024, Номер unknown

Опубликована: Авг. 7, 2024

Abstract Solution state 1 H NMR spectroscopy provides valuable insights into molecular structure and conformation. However, when the spectrum exhibits severe signal overlap, it hampers extraction of key structural information. Here, an ultraselective, ultrahigh resolution TOCSY method is introduced that greatly reduces spectral complexity, allowing previously inaccessible It combines recently developed GEMSTONE excitation with homonuclear decoupling to provide highly simplified through‐bond correlation 1D spectra, showing all signals within selected spin system as singlets. The new can facilitate analysis mixtures, shown here for a mixture Cinchona alkaloids (popular catalysts in asymmetric synthesis) glucocorticoids (used treating conditions such asthma).

Язык: Английский

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Application of Nanobiomedicine in Acute Lung Injury

Journal of Biomaterials and Tissue Engineering, Год журнала: 2024, Номер 14(3), С. 115 - 129

Опубликована: Март 1, 2024

The respiratory system plays a crucial role in human life activities, and acute lung injury (ALI) is highly fatal disease caused by variety of reasons. At present, although several preclinical studies have demonstrated the efficacy pharmacological interventions, supportive care mechanical ventilation still remain primary modalities for managing ALI, there are no safe effective treatments ALI. With rapid development nanotechnology, nanobiomedicines with different structures functional moieties been well-designed based on their targeting ability pathophysiology In this review, it summarizes challenges faced ALI therapy, introduces including liposomes, polymers, inorganic materials, others to bring therapeutic effects discusses research progress recent years nanobiomedicine applied injury. Finally, provides summary prospect application

Язык: Английский

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