Annals of Surgical Oncology, Год журнала: 2024, Номер 31(7), С. 4795 - 4808
Опубликована: Май 17, 2024
Язык: Английский
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(20), С. 11060 - 11060
Опубликована: Окт. 15, 2024
Colorectal cancer (CRC) remains the second most common cause of cancer-related mortality worldwide, necessitating advancements in early detection and innovative treatment strategies. MicroRNAs (miRNAs), small non-coding RNAs involved gene regulation, have emerged as crucial players pathogenesis CRC. This review synthesizes latest findings on miRNA deregulated precancerous lesions By examining deregulation patterns miRNAs across different stages CRC development, this highlights their potential diagnostic tools. We specifically analyse roles relevance four miRNAs-miR-15b, miR-21, miR-31, miR-146a-that consistently exhibit altered expression The current knowledge role key oncogenic pathways, drug resistance, clinical is discussed. Despite challenges posed by heterogeneity research CRC, integrating diagnostics into screening methods holds promise for enhancing personalized medicine approaches. emphasizes transformative diagnosis, paving way improved patient outcomes novel therapeutic paradigms.
Язык: Английский
Процитировано
6
Journal of Functional Foods, Год журнала: 2023, Номер 108, С. 105705 - 105705
Опубликована: Авг. 5, 2023
Hepatocellular carcinoma (HCC), as a common malignancy of the liver, is second leading cause cancer-related death in world and mostly occurs patients with background chronic liver disease. Patents this represent various signs symptoms, such splenomegaly, peripheral edema, jaundice. More than 70 % HCC cases are advanced stage because lacking diagnostic systems indications early stages, therefore giving rise to high lethality rate involved patients. Against malignancy, several therapeutic methods have been recommended, like surgical resection, immunotherapy, transplantation, chemotherapeutic drugs (e.g., doxorubicin, mitomycin C, cisplatin); however, these curative modalities not created serious hope for patents. Nowadays, herbal medicine natural compounds has offered different illnesses, cancer. Among these, some components their nano-based formulations, especially curcumin (a polyphenol extract Curcuma longa), become point interest treating HCC. Hence, review aimed evaluate anticancer effects its biological potential based on current documents.
Язык: Английский
Процитировано
12
Biomedicines, Год журнала: 2023, Номер 11(9), С. 2583 - 2583
Опубликована: Сен. 20, 2023
In diabetes, possibly the most significant site of microvascular damage is kidney. Due to diabetes and/or other co-morbidities, such as hypertension and age-related nephron loss, a number people with suffer from kidney diseases. Improved diabetic care can reduce prevalence nephropathy (DN); however, innovative treatment approaches are still required. MicroRNA-21 (miR-21) one studied multipotent microRNAs (miRNAs), it has been linked renal fibrosis exhibits significantly altered expression in DN. Targeting miR-21 offers an advantage Currently, being pharmacologically silenced through various methods, all which early development. this review, we summarize role molecular pathogenesis DN several therapeutic strategies use target The existing experimental interventions offer way rectify lower miRNA levels well higher levels. Synthetic miRNAs also referred miR-mimics, compensate for abnormally low Furthermore, like oligonucleotides be used alter It reasonable improved results because directly contributes pathological processes diseases, including
Язык: Английский
Процитировано
12
Talanta, Год журнала: 2024, Номер 279, С. 126604 - 126604
Опубликована: Июль 22, 2024
Язык: Английский
Процитировано
5
Annals of Surgical Oncology, Год журнала: 2024, Номер 31(7), С. 4795 - 4808
Опубликована: Май 17, 2024
Язык: Английский
Процитировано
4