Role of MicroRNA-21 in Prostate Cancer Progression and Metastasis: Molecular Mechanisms to Therapeutic Targets DOI
Vipendra Kumar Singh, Naina Rajak,

Yashasvi Singh

и другие.

Annals of Surgical Oncology, Год журнала: 2024, Номер 31(7), С. 4795 - 4808

Опубликована: Май 17, 2024

Язык: Английский

Advances in microRNAs as Emerging Biomarkers for Colorectal Cancer Early Detection and Diagnosis DOI Open Access
Maša Ždralević,

Andrijana Radović,

Janja Raonić

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(20), С. 11060 - 11060

Опубликована: Окт. 15, 2024

Colorectal cancer (CRC) remains the second most common cause of cancer-related mortality worldwide, necessitating advancements in early detection and innovative treatment strategies. MicroRNAs (miRNAs), small non-coding RNAs involved gene regulation, have emerged as crucial players pathogenesis CRC. This review synthesizes latest findings on miRNA deregulated precancerous lesions By examining deregulation patterns miRNAs across different stages CRC development, this highlights their potential diagnostic tools. We specifically analyse roles relevance four miRNAs-miR-15b, miR-21, miR-31, miR-146a-that consistently exhibit altered expression The current knowledge role key oncogenic pathways, drug resistance, clinical is discussed. Despite challenges posed by heterogeneity research CRC, integrating diagnostics into screening methods holds promise for enhancing personalized medicine approaches. emphasizes transformative diagnosis, paving way improved patient outcomes novel therapeutic paradigms.

Язык: Английский

Процитировано

6

Curcumin and its novel formulations for the treatment of hepatocellular carcinoma: New trends and future perspectives in cancer therapy DOI Creative Commons
Seyed Mohammadmahdi Meybodi,

Pouria Rezaei,

Niki Faraji

и другие.

Journal of Functional Foods, Год журнала: 2023, Номер 108, С. 105705 - 105705

Опубликована: Авг. 5, 2023

Hepatocellular carcinoma (HCC), as a common malignancy of the liver, is second leading cause cancer-related death in world and mostly occurs patients with background chronic liver disease. Patents this represent various signs symptoms, such splenomegaly, peripheral edema, jaundice. More than 70 % HCC cases are advanced stage because lacking diagnostic systems indications early stages, therefore giving rise to high lethality rate involved patients. Against malignancy, several therapeutic methods have been recommended, like surgical resection, immunotherapy, transplantation, chemotherapeutic drugs (e.g., doxorubicin, mitomycin C, cisplatin); however, these curative modalities not created serious hope for patents. Nowadays, herbal medicine natural compounds has offered different illnesses, cancer. Among these, some components their nano-based formulations, especially curcumin (a polyphenol extract Curcuma longa), become point interest treating HCC. Hence, review aimed evaluate anticancer effects its biological potential based on current documents.

Язык: Английский

Процитировано

12

MicroRNA-21 Silencing in Diabetic Nephropathy: Insights on Therapeutic Strategies DOI Creative Commons
Yogita Dhas, Numair Arshad, Nupur Biswas

и другие.

Biomedicines, Год журнала: 2023, Номер 11(9), С. 2583 - 2583

Опубликована: Сен. 20, 2023

In diabetes, possibly the most significant site of microvascular damage is kidney. Due to diabetes and/or other co-morbidities, such as hypertension and age-related nephron loss, a number people with suffer from kidney diseases. Improved diabetic care can reduce prevalence nephropathy (DN); however, innovative treatment approaches are still required. MicroRNA-21 (miR-21) one studied multipotent microRNAs (miRNAs), it has been linked renal fibrosis exhibits significantly altered expression in DN. Targeting miR-21 offers an advantage Currently, being pharmacologically silenced through various methods, all which early development. this review, we summarize role molecular pathogenesis DN several therapeutic strategies use target The existing experimental interventions offer way rectify lower miRNA levels well higher levels. Synthetic miRNAs also referred miR-mimics, compensate for abnormally low Furthermore, like oligonucleotides be used alter It reasonable improved results because directly contributes pathological processes diseases, including

Язык: Английский

Процитировано

12

An updated review on the development of a nanomaterial-based field-effect transistor-type biosensors to detect exosomes for cancer diagnosis DOI
Jeongyun An, Hyunjun Park,

Minyoung Ju

и другие.

Talanta, Год журнала: 2024, Номер 279, С. 126604 - 126604

Опубликована: Июль 22, 2024

Язык: Английский

Процитировано

5

Role of MicroRNA-21 in Prostate Cancer Progression and Metastasis: Molecular Mechanisms to Therapeutic Targets DOI
Vipendra Kumar Singh, Naina Rajak,

Yashasvi Singh

и другие.

Annals of Surgical Oncology, Год журнала: 2024, Номер 31(7), С. 4795 - 4808

Опубликована: Май 17, 2024

Язык: Английский

Процитировано

4