Pathology - Research and Practice, Год журнала: 2024, Номер 262, С. 155572 - 155572
Опубликована: Авг. 30, 2024
Язык: Английский
Talanta, Год журнала: 2024, Номер 279, С. 126604 - 126604
Опубликована: Июль 22, 2024
Язык: Английский
Процитировано
5
Journal of Functional Foods, Год журнала: 2023, Номер 108, С. 105705 - 105705
Опубликована: Авг. 5, 2023
Hepatocellular carcinoma (HCC), as a common malignancy of the liver, is second leading cause cancer-related death in world and mostly occurs patients with background chronic liver disease. Patents this represent various signs symptoms, such splenomegaly, peripheral edema, jaundice. More than 70 % HCC cases are advanced stage because lacking diagnostic systems indications early stages, therefore giving rise to high lethality rate involved patients. Against malignancy, several therapeutic methods have been recommended, like surgical resection, immunotherapy, transplantation, chemotherapeutic drugs (e.g., doxorubicin, mitomycin C, cisplatin); however, these curative modalities not created serious hope for patents. Nowadays, herbal medicine natural compounds has offered different illnesses, cancer. Among these, some components their nano-based formulations, especially curcumin (a polyphenol extract Curcuma longa), become point interest treating HCC. Hence, review aimed evaluate anticancer effects its biological potential based on current documents.
Язык: Английский
Процитировано
12
Biomedicines, Год журнала: 2023, Номер 11(9), С. 2583 - 2583
Опубликована: Сен. 20, 2023
In diabetes, possibly the most significant site of microvascular damage is kidney. Due to diabetes and/or other co-morbidities, such as hypertension and age-related nephron loss, a number people with suffer from kidney diseases. Improved diabetic care can reduce prevalence nephropathy (DN); however, innovative treatment approaches are still required. MicroRNA-21 (miR-21) one studied multipotent microRNAs (miRNAs), it has been linked renal fibrosis exhibits significantly altered expression in DN. Targeting miR-21 offers an advantage Currently, being pharmacologically silenced through various methods, all which early development. this review, we summarize role molecular pathogenesis DN several therapeutic strategies use target The existing experimental interventions offer way rectify lower miRNA levels well higher levels. Synthetic miRNAs also referred miR-mimics, compensate for abnormally low Furthermore, like oligonucleotides be used alter It reasonable improved results because directly contributes pathological processes diseases, including
Язык: Английский
Процитировано
12
Small Methods, Год журнала: 2024, Номер unknown
Опубликована: Май 28, 2024
Abstract Ribonucleic acid (RNA) therapeutics offer a broad prospect in cancer treatment. However, their successful application requires overcoming various physiological barriers to effectively deliver RNAs the target sites. Currently, number of RNA delivery systems based on polymeric nanoparticles are developed overcome these delivery. This work provides an overview existing for gene therapy, and particularly summarizes those that entering clinical phase. then discusses core features latest research developments tumor microenvironment‐responsive polymer‐based carriers which designed pathological characteristics microenvironment. Finally, this also proposes opportunities transformation therapies into immunotherapy methods applications.
Язык: Английский
Процитировано
4
Pathology - Research and Practice, Год журнала: 2024, Номер 262, С. 155572 - 155572
Опубликована: Авг. 30, 2024
Язык: Английский
Процитировано
4