Global Trends in Research of Programmed Cell Death in Osteoporosis: A Bibliometric and Visualized Analysis (2000–2023)

Orthopaedic Surgery, Год журнала: 2024, Номер 16(8), С. 1783 - 1800

Опубликована: Июнь 24, 2024

Osteoporosis (OP) is a systemic metabolic bone disease that characterized by decreased mineral density and microstructural damage to tissue. Recent studies have demonstrated significant advances in the research of programmed cell death (PCD) OP. However, there no bibliometric analysis this field. This study searched Web Science Core Collection (WoSCC) database for literature related OP PCD from 2000 2023. used VOSviewers 1.6.20, “bibliometrix” R package, CiteSpace (6.2.R3) visualization analysis. A total 2905 articles 80 countries were included, with China United States leading way. The number publications increasing year year. main institutions are Shanghai Jiao Tong University, Chinese Medical Southern Zhejiang Soochow University. Bone most popular journal field OP, Journal Mineral Research co‐cited journal. These come 14,801 authors, Liu Zong‐Ping, Yang Lei, Manolagas Stavros C, Zhang Wei, Zhao Hong‐Yan having published papers. Ronald S. Weinstein was often. Oxidative stress autophagy current hot spots provides first comprehensive summary trends developments information identifies recent frontiers directions, which will provide definitive reference scholars studying

Язык: Английский

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Diabetic peripheral neuropathy based on Schwann cell injury: mechanisms of cell death regulation and therapeutic perspectives

Frontiers in Endocrinology, Год журнала: 2024, Номер 15

Опубликована: Авг. 12, 2024

Diabetic peripheral neuropathy (DPN) is a complication of diabetes mellitus that lacks specific treatment, its high prevalence and disabling neuropathic pain greatly affects patients’ physical mental health. Schwann cells (SCs) are the major glial nervous system, which play an important role in various inflammatory metabolic neuropathies by providing nutritional support, wrapping axons promoting repair regeneration. Increasingly, glucose (HG) has been found to promote progression DPN pathogenesis targeting SCs death regulation, thus revealing molecular process programmed cell (PCD) disrupted link gain insight into DPN. This paper first review recent progress HG studies on apoptosis, autophagy, pyroptosis, ferroptosis necroptosis pathways SCs, points out crosstalk between PCDs related therapeutic perspectives, with aim new perspectives for deeper understanding mechanisms exploration effective targets.

Язык: Английский

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Investigating the Molecular Mechanisms of Jiangu Decoction in Treating Type 2 Diabetic Osteoporosis

Journal of Ethnopharmacology, Год журнала: 2025, Номер 341, С. 119346 - 119346

Опубликована: Янв. 10, 2025

Язык: Английский

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Role of sirtuins in obesity and osteoporosis: molecular mechanisms and therapeutic targets

Cell Communication and Signaling, Год журнала: 2025, Номер 23(1)

Опубликована: Янв. 11, 2025

The prevalence of obesity and osteoporosis (OP) represents a significant public health concern on global scale. A substantial body evidence indicates that there is complex relationship between OP, with correlation the occurrence OP obesity. In recent years, sirtuins have emerged as prominent area interest in fields aging endocrine metabolism. Among various research avenues exploring potential sirtuins, effects these proteins garnered attention from numerous researchers. Sirtuins regulate energy balance lipid balance, which turn inhibit process adipogenesis. Additionally, osteogenic osteoblastic activity, protects against development OP. However, no study has yet provided comprehensive discussion three: obesity, This paper will therefore describe focusing possibility treating caused by targeting sirtuins. be based common influences (such mesenchymal stem cells, gut microbiota, insulin). Finally, SIRT1, an important member polyphenolic natural products for treatment presented. contribute to better understanding interactions bone, facilitate new therapeutic strategies future.

Язык: Английский

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5,7-Dihydroxy-4-Methylcoumarin enhances osteogenesis and ameliorates osteoporosis via the AKT1 pathway

Biochemical Pharmacology, Год журнала: 2025, Номер 233, С. 116752 - 116752

Опубликована: Янв. 10, 2025

Язык: Английский

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