Shijie huaren xiaohua zazhi, Год журнала: 2024, Номер 32(5), С. 320 - 326
Опубликована: Май 28, 2024
Язык: Английский
Journal of Hematology & Oncology, Год журнала: 2024, Номер 17(1)
Опубликована: Март 22, 2024
Abstract Inflammation has accompanied human beings since the emergence of wounds and infections. In past decades, numerous efforts have been undertaken to explore potential role inflammation in cancer, from tumor development, invasion, metastasis resistance tumors treatment. Inflammation-targeted agents not only demonstrate suppress cancer but also improve efficacy other therapeutic modalities. this review, we describe highly dynamic complex inflammatory microenvironment, with discussion on key mediators including cells, cytokines, their downstream intracellular pathways. addition, especially address development highlight action mechanisms inflammation-targeted therapies antitumor response. Finally, summarize results both preclinical clinical studies up date illustrate translation therapies.
Язык: Английский
Процитировано
30
Journal of Separation Science, Год журнала: 2025, Номер 48(1)
Опубликована: Янв. 1, 2025
ABSTRACT A novel dual‐wavelength ultrahigh performance liquid chromatography (UHPLC) fingerprint was established, 56 common peaks were confirmed and attributed to the source of medicinal materials, 13 chromatographic them identified by UHPLC quadrupole time‐of‐flight (Q‐TOF)‐MS/MS UHPLC‐UV method. Furthermore, a simple sensitive HPLC‐quadrupole trap (Q‐TRAP)‐MS/MS developed for simultaneous determination 16 active components with electrospray ionization (ESI) switching between positive negative modes in single run. The above two methods successfully applied quality evaluation Guanxinjing capsule (GXJC). Finally, statistical analysis including principal component (PCA), hierarchical cluster (HCA), orthogonal partial least squares discriminate (OPLS‐DA) applied, variables great contribution different groups samples screened. This study not only provides rapid, accurate, comprehensive qualitative quantitative method GXJC but it also reference workflow other traditional Chinese medicines.
Язык: Английский
Процитировано
2
Frontiers in Pharmacology, Год журнала: 2024, Номер 15
Опубликована: Авг. 9, 2024
Due to the pathological production of liver disease in utility particularly complexity, morbidity and mortality including viral hepatitis, fibrosis/cirrhosis hepatocellular carcinoma (HCC) are rapidly increasing worldwide. Considering its insidious onset, rapid progression drug resistance, finding an effective therapy is worthwhile.
Язык: Английский
Процитировано
5
Pharmacological Research, Год журнала: 2025, Номер unknown, С. 107733 - 107733
Опубликована: Апрель 1, 2025
Hepatocellular carcinoma (HCC), originating from hepatocytes, is the most common type of primary liver cancer. HCC imposes a significant global health burden with high morbidity and mortality, making it critical public concern. Surgical interventions, including hepatectomy transplantation, are pivotal in achieving long-term survival for patients HCC. Additionally, ablation therapy, endovascular interventional radiotherapy, systemic anti-tumor therapies commonly employed. However, these treatment modalities often associated considerable challenges, postoperative recurrence rates adverse effects. Traditional Chinese medicine (TCM) natural products have been utilized centuries as complementary approach managing its complications, demonstrating favorable clinical outcomes. Various bioactive compounds derived TCM identified purified, their mechanisms action extensively investigated. This review aims to provide comprehensive up-to-date evaluation efficacy TCM, active constituents management Particular emphasis placed on elucidating potential molecular therapeutic targets agents, roles inhibiting cell proliferation, inducing apoptosis pyroptosis, suppressing tumor invasion metastasis, restraining angiogenesis within tissues.
Язык: Английский
Процитировано
0
Heliyon, Год журнала: 2024, Номер 10(3), С. e24437 - e24437
Опубликована: Янв. 11, 2024
BackgroundTraditional Chinese Medicine (TCM), has been used for hepatocellular carcinoma (HCC) at every therapeutic stage, even before tumor formation. However, the efficacy of TCM in reducing incidence HCC patients with chronic hepatitis B-related cirrhosis remains unclear. This study aims to address this gap.MethodsPublications were collected from PubMed, EMBASE, Cochrane Library, Web Science, CNKI, Sino Med, VIP, and Wan Fang Databases. Relative risk (RR) was calculated a 95 % confidence interval (CI). Heterogeneity assessed. The Collaboration's tool assess bias.Results10 studies 2702 showed that combination therapy significantly reduced post-hepatitis B 1, 3, 5 years. preventive effects compensated cirrhosis, but not decompensated cirrhosis. Furthermore, correlated improved liver function enhanced virological response.ConclusionCombination demonstrated certain potential is attrinuted improvement enhancement viral response. field still needs more high-quality RCTs provide stronger evidence future.
Язык: Английский
Процитировано
4
Phytomedicine, Год журнала: 2025, Номер 137, С. 156363 - 156363
Опубликована: Янв. 2, 2025
Язык: Английский
Процитировано
0
Frontiers in Pharmacology, Год журнала: 2025, Номер 15
Опубликована: Янв. 7, 2025
Liver fibrosis is a globally prevalent chronic liver disease, often representing the advanced stage of various conditions. Despite its widespread occurrence, there currently no widely accepted or effective treatment for fibrosis. However, increasing evidence supports efficacy Traditional Chinese Medicine (TCM) in inhibiting progression In this study, we explored effects and potential mechanisms Qizhu-Ruogan-Granules (QZRG), formulation from Affiliated Hospital Chengdu University TCM, on carbon tetrachloride (CCl4)-induced mice. A total 40 male C57BL/6J mice were randomly divided into five groups (n = 8 per group), with induced by injecting 10% CCl4 15 weeks. From 7th week onward, QZRG granules administered orally to at low, medium, high doses. To assess function, serum levels alanine aminotransferase (ALT), aspartate (AST), alkaline phosphatase (ALP) measured. morphology evaluated using hematoxylin-eosin (H&E) Masson's trichrome staining, while gene protein expression analyzed through quantitative reverse transcription polymerase chain reaction (RT-PCR) western blot techniques. The results showed that significantly reduced AST, ALT, ALP CCl4-treated mice, alleviated damage, collagen accumulation. Furthermore, inhibited apoptosis-related proteins BAX, Caspase9, Caspase8, Caspase3, reducing P2Y14 fibrotic tissues. Additionally, suppressed proliferation activated hepatic stellate cells. Our findings suggest may exert anti-fibrotic downregulating effectively slowing
Язык: Английский
Процитировано
0
Natural Product Communications, Год журнала: 2025, Номер 20(1)
Опубликована: Янв. 1, 2025
Hepatic fibrosis (HF), a global issue that develops gradually during the repeated repair process of chronic liver injury caused by various factors, can progress to irreversible cirrhosis and hepatocellular carcinoma. Currently, there are no approved chemical or biological drugs for treatment fibrosis. Modern medicine primarily focuses on addressing underlying causes HF is classified as an accumulative disease in Yellow Emperor's Internal Classic, which earliest most influential extant medical classic China. Thousands years experience have accumulated large number effective Chinese medicines. In recent years, studies anti-liver effects mainly focused curative extracts compounds. Studies shown prevention through demonstrate comprehensive pharmacological effect involves multiple pathways targets. Therefore, further in-depth research this field both promising necessary. However, it crucial expand clinical application studies, current TCM predominantly limited laboratory investigations. review, we summarized effects, targets related mechanisms 13 traditional medicines past five order provide information development drugs.
Язык: Английский
Процитировано
0
Journal of Ethnopharmacology, Год журнала: 2023, Номер 321, С. 117514 - 117514
Опубликована: Дек. 1, 2023
Язык: Английский
Процитировано
7
Frontiers in Pharmacology, Год журнала: 2024, Номер 15
Опубликована: Март 28, 2024
Background: The occurrence and development of Hepatic fibrosis (HF) are closely related to the gut microbial composition alterations in host metabolism. Qijia Rougan decoction (QJ) is a traditional Chinese medicine compound utilized clinically for treatment HF with remarkable clinical efficacy. However, its effect on microbiota metabolite unknown. Therefore, our objective was examine impact QJ metabolism Carbon tetrachloride (CCl 4 )-induced HF. Methods: 40% CCl used induce HF, followed by administration 6 weeks. Serum biochemical analyses, histopathology, immunohistochemistry, RT-PCR, 16S rRNA gene sequencing, non-targeted metabolomics techniques were employed this study investigate interventional effects -induced model rats. Results: This demonstrated that could effectively ameliorate hepatic inflammation fibrosis. Moreover, upregulated expression intestinal tight junction proteins (TJPs) notably altered abundance some microbes, example, 10 genera associated HF-related indicators TJPs. In addition, found 37 key metabolites responded strongly indices Furthermore, relation between post correlation analysis. Among them, Turicibacter , Faecalibaculum Prevotellaceae UCG 001 unclassified Peptococcaceae may serve as core microbes inhibit Conclusion: These results suggest ameliorates fibrosis, which be achieved improving junctions modulating well
Язык: Английский
Процитировано
2