Hepatitis B: Model Systems and Therapeutic Approaches

Journal of Immunology Research, Год журнала: 2024, Номер 2024, С. 1 - 15

Опубликована: Май 7, 2024

Hepatitis B virus (HBV) infection is a major global health issue and ranks among the top causes of liver cirrhosis hepatocellular carcinoma. Although current antiviral medications, including nucleot(s)ide analogs interferons, could inhibit replication HBV alleviate disease, cannot be fully eradicated. The development cellular animal models for plays an important role in exploring effective anti-HBV medicine. During past decades, advancements several cell culture systems, such as HepG2.2.15, HepAD38, HepaRG, hepatocyte-like cells, primary human hepatocytes, have propelled research inhibiting expression thus enriched our comprehension viral life cycle enhancing drug evaluation efficacy. Mouse models, particular, emerged most extensively studied models. Additionally, present landscape therapeutics now encompasses comprehensive assessment virus’s cycle, targeting numerous facets employing variety immunomodulatory approaches, entry inhibitors, strategies aimed at cccDNA, RNA interference technologies, toll-like receptor agonists, and, notably, traditional Chinese medicine (TCM). This review describes attributes limitations existing model systems surveys novel treatment modalities, which will offer deeper insights toward discovering potentially efficacious pharmaceutical interventions.

Язык: Английский

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Cornus officinalis with high pressure wine steaming enhanced anti-hepatic fibrosis: Possible through SIRT3-AMPK axis

Journal of Pharmaceutical Analysis, Год журнала: 2023, Номер 14(5), С. 100927 - 100927

Опубликована: Дек. 21, 2023

Cornus officinalis, a medicinal and edible plant known for its liver-nourishing properties, has shown promise in inhibiting the activation of hepatic stellate cells (HSCs), crucial indicators fibrosis, especially when processed by high pressure wine steaming (HPWS). Herein, this study aims to investigate regulatory effects cornus both raw HPWS forms, on inflammation apoptosis liver fibrosis their underlying mechanisms. In vivo models were established subcutaneous injection CCl4, while vitro HSCs exposed transforming growth factor-β (TGF-β). These findings demonstrated that officinalis with conspicuously ameliorated histopathological injury, reduced release proinflammatory factors, decreased collagen deposition CCl4-induced rats compared form. Utilizing ultra-high-performance liquid chromatography coupled quadrupole time-of-flight mass spectrometer (UHPLC-QTOF-MS) combined network analysis, we identified pharmacological changed components before after HPWS, primarily centered adenosine phosphate (AMP)-activated protein kinase (AMPK) pathway. Of note, activated AMPK Sirtuin 3 (SIRT3), promoting through caspase cascade regulating caspase3, caspase6 caspase9. siRNA experiments showed could regulate activity mediated-apoptosis SIRT3. conclusion, exhibited ability reduce apoptosis, SIRT3-AMPK signaling pathway as potential mechanism synergistic effect anti-liver fibrosis.

Язык: Английский

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An herbal formula Shenlian decoction upregulates M1/M2 macrophage proportion in hepatocellular carcinoma by suppressing complement cascade

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 177, С. 116943 - 116943

Опубликована: Июнь 14, 2024

The immunosuppressive microenvironment is a vital factor for the hepatocellular carcinoma (HCC) progression. However, effective treatment lacking at current. Shenlian decoction (SLD) registered herbal therapy HCC treatment, but underlying mechanism of SLD remains largely elusive. Here, we aimed to explore anti-tumor effect in HCC. was intragastrically given after tumor initiation β-catenin/C-Met or DEN and CCl

Язык: Английский

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Traditional Chinese herbal medicine: harnessing dendritic cells for anti-tumor benefits

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Сен. 19, 2024

Chinese Herbal Medicine (CHM) is being more and used in cancer treatment because of its ability to regulate the immune system. has several advantages over other options, including multi-component, multi-target, having fewer side effects. Dendritic cells (DCs) are specialized antigen presenting that play a vital part connecting innate adaptive systems. They also important immunotherapy. Recent evidence suggests components can positively impact response by targeting key functions dendritic cells. In this review, we have summarized influences on immunobiological feature cells, emphasized an anti-tumor effect CHM-treated DCs, pointed out deficiencies regulation DC function outlined future research directions.

Язык: Английский

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Effect of ozone gas on viral kinetics and liver histopathology in hepatitis C patients

Journal of Complementary and Integrative Medicine, Год журнала: 2024, Номер 21(1), С. 131 - 138

Опубликована: Янв. 8, 2024

Abstract Objectives We examine how well ozone/oxygen gas therapy treats chronic hepatitis C patients with varying degrees of liver fibrosis. Also to study the effect giving multiple anti-oxidants mixture, see if this addition would have any additive or synergistic effect. Methods Two hundred and twenty three C. Liver biopsies were carried out at after 12 weeks administering an mixture. Results The mean stage fibrosis decreased from 1.98 1.41 grade inflammation 10.08 7.94, both a p value less than 0.001. After treatment, PCR values increased. No single significant complication was recorded in total >9,000 settings ozone therapy. Conclusions Ozone oxygen mixture is safe effective treatment hepatic due viral

Язык: Английский

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Liver cirrhosis reversal and recompensation: Existing evidence and future prospects

Shijie huaren xiaohua zazhi, Год журнала: 2024, Номер 32(5), С. 320 - 326

Опубликована: Май 28, 2024

Язык: Английский

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