An overlap-weighted analysis on the association of constipation symptoms with disease progression and survival in amyotrophic lateral sclerosis: a nested case-control study

Therapeutic Advances in Neurological Disorders, Год журнала: 2025, Номер 18

Опубликована: Янв. 1, 2025

Background: Amyotrophic lateral sclerosis (ALS) is a rapidly progressing and rare neurodegenerative disease. Therefore, evaluating the risk factors affecting survival of patients with ALS crucial. Constipation, common but overlooked symptom ALS, can be effectively managed. It currently unknown whether constipation contributes to progression ALS. Objectives: This study aimed investigate association between development using novel overlap-weighted (OW) method enhance robustness reliability results. Design: prospective matching nested case-control (NCC) was conducted within an ongoing cohort at Second Hospital Hebei Medical University. Baseline data were collected from meeting inclusion exclusion criteria, as exposure factor. A 9-month follow-up conducted, death endpoint event. Methods: We primarily used OW in NCC studies examine survival. Weighted Cox proportional hazards model assess associated overall Survival differences two groups analyzed Kaplan-Meier’s plots log-rank tests. Finally, bioinformatic analysis explored pathways constipation. Results: Among 190 included, prevalence 50%. Patients exhibited faster disease ( p < 0.001), positive correlation severity rate r = 0.356, 0.001). The group had poorer before after (log-rank test, 0.0001). In 114 patients, factor for both (hazard ratio (HR) 5.840, 95% confidence interval (CI) 1.504–22.675, 0.011) (HR 5.271, CI 1.241–22.379, 0.024) OW. Conclusion: Constipation individuals reduced rates, potentially through peroxisome proliferator-activated receptor pathway.

Язык: Английский

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Characterization of Genomic, Physiological, and Probiotic Features of Lactiplantibacillus plantarum JS21 Strain Isolated from Traditional Fermented Jiangshui

Foods, Год журнала: 2024, Номер 13(7), С. 1082 - 1082

Опубликована: Апрель 1, 2024

This study aimed to understand the genetic and metabolic traits of a Lactiplantibacillus plantarum JS21 strain its probiotic abilities through laboratory tests computer analysis. L. was isolated from traditional fermented food known as “Jiangshui” in Hanzhong city. In this research, complete makeup determined using Illumina PacBio technologies. The genome consisted 3.423 Mb circular chromosome five plasmids. It found contain 3023 protein-coding genes, 16 tRNA 64 rRNA operons, 40 non-coding RNA 264 pseudogenes, six CRISPR array regions. GC content 44.53%. Additionally, harbored three prophages. evolutionary relationship collinearity were compared with other strains. resistance genes identified inherent. Enzyme involved Embden–Meyerhof–Parnas (EMP) phosphoketolase (PK) pathways detected, indicating potential for facultative heterofermentative pathways. possessed bacteriocins plnE/plnF polyketide terpenoid assembly, possibly contributing antibacterial properties against Escherichia coli (ATCC 25922), (K88), Staphylococcus aureus (CMCC 26003), Listeria monocytogenes (CICC 21635). Furthermore, carried Na+/H+ antiporters, F0F1 ATPase, stress which may account ability withstand simulated conditions human gastrointestinal tract vitro. high hydrophobicity cell surface suggested intestinal colonization. Overall, exhibited evidenced by experiments computational analysis, suggesting suitability dietary supplement.

Язык: Английский

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Integrated HS-GC–IMS and UPLC-Q-Orbitrap HRMS-based metabolomics revealed the characteristics and differential volatile and nonvolatile metabolites of different citrus peels

Current Research in Food Science, Год журнала: 2024, Номер 8, С. 100755 - 100755

Опубликована: Янв. 1, 2024

Citrus is an important genus in the Rutaceae family, and citrus peels can be used both food herbal medicine. However, bulk of are discarded as waste by fruit processing industry, causing environmental pollution. This study aimed to provide guidelines for rational effective use elucidating volatile nonvolatile metabolites within them using metabolomics based on headspace-gas chromatography–ion mobility spectrometry ultra-high-performance liquid chromatography–Q-Orbitrap high-resolution mass spectrometry. In addition, antioxidant activities were evaluated DPPH radical scavenging, ABTS ferric reducing power. total, 103 53 identified characterized. Alcohols, aldehydes, terpenes constituted 87.36% metabolites, while flavonoids carboxylic acids accounted 85.46% metabolites. Furthermore, (Z)-2-penten-1-ol, L-pipecolinic acid, limonin characteristic components reticulata Blanco cv. Ponkan (PK), C. 'Unshiu' (CLU), 'Wo Gan' (WG), respectively. Principal component analysis partial least squares discriminant indicated that 'Chun Jian' (CJ), PK, CLU, 'Dahongpao' (DHP) clustered together. DHP a traditional Chinese medicine documented Pharmacopoeia, suggesting chemical compositions CJ, CLU may also have medicinal values similar those DHP. Moreover, DHP, 'Ai Yuan 38'(AY38), 'Gan Ping'(GP), 'Qing Jian'(QJ) displayed better activities, recommending their additives cosmetics food. Correlation suggested some polyphenols including tangeritin, nobiletin, skullcapflavone II, genistein, caffeic isokaempferide potential compounds peel. The results this deepen our understanding differences different peel varieties ultimately guidance full peels.

Язык: Английский

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Lactic acid bacteria in relieving constipation: mechanism, clinical application, challenge, and opportunity

Critical Reviews in Food Science and Nutrition, Год журнала: 2023, Номер unknown, С. 1 - 24

Опубликована: Ноя. 16, 2023

Constipation is a prevalent gastrointestinal symptom that can considerably affect patients' quality of life. Although several drugs have been used to treat constipation, they are associated with high costs, side effects, and low universality. Therefore, alternative intervention strategies urgently needed. Traditional lactic acid bacteria (LAB), such as Bifidobacterium Lactobacillus, play vital role in regulating intestinal microecology demonstrated favorable effects constipation; however, comprehensive review their constipation relief mechanisms limited. This summarizes the pathogenesis relationship between motility gut microbiota, elucidates possible mechanism by which LAB alleviates through systematic summary animal clinical research, highlights challenges applications treatment constipation. Our improve our understanding advance targeted microecological therapeutic agents, LAB.

Язык: Английский

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A randomized, double-blind, placebo-controlled clinical study to evaluate the efficacy and safety of Weizmannia coagulans BC99 in the treatment of chronic constipation in adults

Frontiers in Nutrition, Год журнала: 2024, Номер 11

Опубликована: Июль 25, 2024

has emerged as a promising candidate for the management of gastrointestinal ailments. The novel strain

Язык: Английский

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Study on encapsulation of Lactobacillus plantarum 23-1 in W/O/W emulsion stabilized by pectin and zein particle complex

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 279, С. 135346 - 135346

Опубликована: Сен. 4, 2024

Язык: Английский

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Effectiveness of Probiotics in Patients With Constipation: A Systematic Review and Meta-Analysis

Cureus, Год журнала: 2024, Номер unknown

Опубликована: Янв. 10, 2024

A recent meta-analysis suggests that probiotic supplementation is moderately efficacious in decreasing intestinal transit times compared with control, demonstrating probiotics' potential for treating chronic idiopathic constipation. This decrease has been proposed to be attributed the capacity of probiotics alter gastrointestinal microflora, improve motility, and biochemical factors. Therefore, a systematic review were conducted estimate effectiveness patients The search was performed using PubMed, PMC, Medline databases. Relevant data extracted assessed quality Cochrane risk bias assessment tool randomized clinical trials (RCTs). random effects model I2 statistic used pooled prevalence explore heterogeneity. Subgroup analyses based on experimental group placebo group. Sensitivity analysis performed, publication explored. Our ' efficacy constipation management by incorporating sample size comprising 1,243 drawn from 10 distinct studies. unveiled heterogeneity 95%, accompanied statistically significant (p-value < 0.05) unequivocally favored over These findings underscore individuals They support imperative fortify this body evidence through robust, larger-scale RCTs deepen our understanding manifold benefits confer nurturing sustaining optimal gut health.

Язык: Английский

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Lactiplantibacillus plantarum P9 for chronic diarrhea in young adults: a large double-blind, randomized, placebo-controlled trial

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Авг. 9, 2024

Current treatments for chronic diarrhea have limited efficacy and several side effects. Probiotics the potential to alleviate symptoms of diarrhea. This randomized, double-blind, placebo-controlled trial evaluates effects administering probiotic Lactiplantibacillus plantarum P9 (P9) strain in young adults with (Clinical Trial Registration Number: ChiCTR2000038410). The intervention period lasts 28 days, followed by a 14-day post-intervention period. Participants are randomized into (n = 93) placebo 96) groups, 170 individuals completing double-blind phase 85 per group). primary endpoint is symptom severity score. Both intention-to-treat 189) per-protocol 170) analyses reveal modest yet statistically significant reduction compared group (20.0%, P 0.050; 21.4%, 0.048, respectively). In conclusion, results this study support use probiotics managing adults. However, lack blood parameter assessment short represent limitations study.

Язык: Английский

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A comprehensive review of the characterization, host interactions, and stabilization advancements on probiotics: Addressing the challenges in functional food diversification

Comprehensive Reviews in Food Science and Food Safety, Год журнала: 2024, Номер 23(5)

Опубликована: Авг. 13, 2024

The demand for functional food is rising in tandem with the prevalence of chronic diseases. Probiotics play a crucial role development, yet their ability to confer health benefits host remains topic debate according Food and Agriculture Organization/World Health Organization requirements. application culturomics, innovative isolation techniques, within realm probiotics increasingly deemed essential fully harnessing latent potential microbial reservoirs. Nevertheless, its confined predominantly human fecal sources. Following integration probiogenomics, significant advancements have been made safety assessment probiotics. However, adoption novel probiotic microorganisms has match requisite pace. Progress research concerning host-probiotic interactions by employing omics technologies, particularly animal models, notable. Nonetheless, comprehensive elucidation mechanisms action trial studies are lagging behind. Additionally, viability probiotics, spanning from production as foods transit colon, markedly improved through encapsulation techniques. opportunities exploration persist regarding alternative coating materials diverse methodologies. Furthermore, there discernible transition domain probiotic-based foods, shifting away primarily dairy-centric focus toward inclusion broader array categories. This review addresses critical issues ranging sources techniques final developments. while doing so, it explores probiogenomics applications characterization, investigations into interactions, strategies stabilization under harsh environmental conditions.

Язык: Английский

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Weizmannia coagulans BC99 Relieves Constipation Symptoms by Regulating Inflammatory, Neurotransmitter, and Lipid Metabolic Pathways: A Randomized, Double-Blind, Placebo-Controlled Trial

Foods, Год журнала: 2025, Номер 14(4), С. 654 - 654

Опубликована: Фев. 15, 2025

Probiotics have attracted increasing attention due to their benefits in terms of relieving gastrointestinal ailments, including constipation. This study evaluated the potential Weizmannia coagulans BC99 for clinical remission constipation adults. In this randomized, double-blind, and placebo-controlled trial, 90 individuals with were divided between a placebo group an 8-week intervention duration. The spontaneous bowel movement (SBM) frequency, patient assessment symptoms (PAC-SYM), quality life (PAC-QOL), inflammatory cytokines, neurotransmitters, serum metabolites investigated before after intervention. results showed that significantly improved adults constipation, as evidenced by increased SBM score decreased PAC-SYM PAC-QOL scores. Additionally, supplementation levels neurotransmitters (5-HT, MTL, AChE, BDNF) associated intestinal motility alleviated inflammation participants supported higher anti-inflammatory factors (IL-4, IL-10) lower pro-inflammatory (IL-6, IFN-γ) group. Furthermore, altered abundance 93 affected biological pathways correlated motility, sphingolipid metabolism, steroid hormone biosynthesis, glycerophospholipid metabolism. demonstrates effectiveness W. strain adults, reveals its mechanism action. These findings provide scientific basis effective safe probiotic treatment.

Язык: Английский

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