Journal of Experimental & Clinical Cancer Research,
Год журнала:
2024,
Номер
43(1)
Опубликована: Авг. 3, 2024
Abstract
The
resistance
of
cancer
cells
to
treatment
significantly
impedes
the
success
therapy,
leading
recurrence
various
types
cancers.
Understanding
specific
mechanisms
therapy
may
offer
novel
approaches
for
alleviating
drug
in
cancer.
Recent
research
has
shown
a
reciprocal
relationship
between
circular
RNAs
(circRNAs)
and
N6-methyladenosine
(m6A)
modification,
their
interaction
can
affect
sensitivity
therapy.
This
review
aims
summarize
latest
developments
m6A
modification
circRNAs
importance
regulating
Furthermore,
we
explore
mutual
exact
provide
insights
into
potential
future
reversing
resistance.
Molecular Medicine Reports,
Год журнала:
2024,
Номер
31(1)
Опубликована: Окт. 18, 2024
Diabetic
wounds
represent
a
significant
complication
of
diabetes
and
present
substantial
challenge
to
global
public
health.
Macrophages
are
crucial
effector
cells
that
play
pivotal
role
in
the
pathogenesis
diabetic
wounds,
through
their
polarization
into
distinct
functional
phenotypes.
The
field
epigenetics
has
emerged
as
rapidly
advancing
research
area,
this
phenomenon
potential
markedly
affect
gene
expression,
cellular
differentiation,
tissue
development
susceptibility
disease.
Understanding
epigenetic
mechanisms
is
further
exploring
disease
pathogenesis.
A
growing
body
scientific
evidence
highlighted
regulation
macrophage
Various
mechanisms,
such
DNA
methylation,
histone
modification
non‑coding
RNAs,
involved
modulation
phenotype
differentiation
response
various
environmental
stimuli
wounds.
review
provided
an
overview
changes
take
place
phenotypes
functions
within
discussed
emerging
modifications
terms
regulating
plasticity
It
hoped
synthesis
information
will
facilitate
elucidation
wound
identification
therapeutic
targets.
Shock,
Год журнала:
2024,
Номер
62(1), С. 119 - 126
Опубликована: Март 25, 2024
ABSTRACT
Background
:
It
is
reported
that
circVMA21
has
an
inhibition
effect
on
sepsis-induced
acute
kidney
injury
(AKI).
Therefore,
the
underlying
molecular
mechanisms
of
in
AKI
are
worthy
further
investigation.
Material
and
Methods
Lipopolysaccharide
(LPS)
was
used
to
induce
HK2
cell
injury.
CircVMA21,
miR-337-3p
ZEB2
expression
tested
by
qRT-PCR.
Cell
growth
detected
CCK8
assay,
EdU
flow
cytometry.
Protein
levels
were
examined
western
blot.
The
inflammatory
factors
oxidative
stress
markers
measured
evaluate
response
stress.
RNA
relationship
as
verified
dual-luciferase
reporter
RIP
pull-down
assay.
Results
CircVMA21
had
decreased
patients.
Overexpressed
alleviated
LPS-induced
inflammation,
apoptosis,
Moreover,
sponged
miR-337-3p,
targeted
ZEB2.
inhibitory
reversed
overexpression,
overexpression
abolished
promotion
Conclusions
could
inhibit
via
miR-337-3p/ZEB2
axis.
Non-Coding RNA,
Год журнала:
2024,
Номер
10(5), С. 51 - 51
Опубликована: Сен. 30, 2024
Epithelial
ovarian
cancer
(EOC)
with
its
high
death
incidence
rate
is
generally
detected
at
advanced
stages.
During
progression,
EOC
often
develops
peritoneal
metastasis
aggravating
the
outcomes
of
patients.
Studies
on
non-coding
RNAs
(ncRNAs),
such
as
microRNAs
(miRNAs)
and
circular
(circRNAs),
have
analyzed
impact
miRNAs
circRNAs,
along
their
interaction
among
each
other,
cells.
MiRNAs
can
act
oncogenes
or
tumor
suppressors
modulating
post-transcriptional
gene
expression.
There
accumulating
evidence
that
circRNAs
apply
stable,
covalently
closed,
continuous
structures
to
competitively
inhibit
miRNA
function,
so
competing
endogenous
(ceRNAs).
This
interplay
between
both
ncRNAs
participates
in
malignity
a
variety
types,
including
EOC.
In
current
review,
I
describe
characteristics
discuss
other
development,
drug
resistance
Sponging
by
may
be
used
biomarker
therapeutic
target
