The Promoting Effect of Animal Bioactive Proteins and Peptide Components on Wound Healing: A Review

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(23), С. 12561 - 12561

Опубликована: Ноя. 22, 2024

The skin is the first line of defense to protect host from external environmental damage. When damaged, wound provides convenience for invasion substances. prolonged nonhealing wounds can also lead numerous subsequent complications, seriously affecting quality life patients. To solve this problem, proteins and peptide components that promote healing have been discovered in animals, which act on key pathways involved healing, such as PI3K/AKT, TGF-β, NF-κ B, JAK/STAT pathways. So far, some formulations topical drug delivery developed, including hydrogels, microneedles, electrospinning nanofibers. In addition, high-performance dressings utilized, great potential healing. Here, research progress promotion by animal-derived summarized, future directions are discussed.

Язык: Английский

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In vitro activity of Tityus metuendus and Brotheas amazonicus scorpion venoms against Plasmodium falciparum FRC3

IP International Journal of Medical Microbiology and Tropical Diseases, Год журнала: 2024, Номер 10(1), С. 24 - 28

Опубликована: Апрель 15, 2024

Scorpion venoms contain different classes of molecules with possible pharmacological activities, making them sources bioactive for the development new drugs against infections caused by pathogens, such as malaria, a disease protozoa genus Plasmodium. Malaria faces challenges in its control due to pathogen resistance available antimalarials. In this study, we evaluated venom activity Amazonian scorpions and FRC3, analysis was performed flow cytometry. At analyzed concentrations, found that crude had an average inhibition 87% at concentration 100 µg/mL, above obtained drug (quinine), which mean 84% FCR3. Regarding , lower observed comparison potential standard drug, showed low toxicity human fibroblast MRC5. Because peptides toxins from scorpion are related biological functions, they can be used design therapeutic agents, being source antimalarial drugs.

Язык: Английский

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Electrophysiological evaluation of the effect of peptide toxins on voltage-gated ion channels: a scoping review on theoretical and methodological aspects with focus on the Central and South American experience

˜The œJournal of venomous animals and toxins including tropical diseases, Год журнала: 2024, Номер 30

Опубликована: Янв. 1, 2024

Язык: Английский

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Structure–Function Relationship of a Novel MTX-like Peptide (MTX1) Isolated and Characterized from the Venom of the Scorpion Maurus palmatus

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(19), С. 10472 - 10472

Опубликована: Сен. 28, 2024

Maurotoxin (MTX) is a 34-residue peptide from

Язык: Английский

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Therapeutics of animal-derived compounds in proteases-induced cancer

Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 309 - 326

Опубликована: Ноя. 1, 2024

Язык: Английский

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