Genetic analysis of diagnostic and therapeutic potential for ferroptosis in postoperative sepsis

International Immunopharmacology, Год журнала: 2025, Номер 147, С. 114042 - 114042

Опубликована: Янв. 9, 2025

Язык: Английский

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Neuroprotective Role of Da Qin Jiu Decoction in Ischemic Stroke: Mitochondrial Rescue through PI3K/Akt-Mediated UPRmt Activation

Journal of Ethnopharmacology, Год журнала: 2025, Номер unknown, С. 119433 - 119433

Опубликована: Фев. 1, 2025

Язык: Английский

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Decoding ferroptosis: Revealing the hidden assassin behind cardiovascular diseases

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 176, С. 116761 - 116761

Опубликована: Май 23, 2024

The discovery of regulatory cell death processes has driven innovation in cardiovascular disease (CVD) therapeutic strategies. Over the past decade, ferroptosis, an iron-dependent form regulated by excessive lipid peroxidation, been shown to drive development multiple CVDs. This review provides insights into evolution concept similarities and differences with traditional modes programmed (e.g., apoptosis, autophagy, necrosis), as well core mechanisms ferroptosis (including cystine/glutamate transporter blockade, imbalance iron metabolism, peroxidation). In addition, it not only a detailed role its potential widely studied CVDs such coronary atherosclerotic heart disease, myocardial infarction, ischemia/reperfusion injury, failure, cardiomyopathy, aortic aneurysm but also overview phenomenon perspectives lesser-addressed cardiac valvulopathy, pulmonary hypertension, sickle disease. article aims integrate this knowledge provide comprehensive view wide range progress strategies field.

Язык: Английский

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Revealing the polarity decrease of cardiomyocyte in the septic cardiomyopathy by a lipid droplets-targeting fluorescent probe with NIR emission

Talanta, Год журнала: 2024, Номер 278, С. 126452 - 126452

Опубликована: Июнь 22, 2024

Язык: Английский

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Mitophagy and Ferroptosis in Sepsis-Induced ALI/ARDS: Molecular Mechanisms, Interactions and Therapeutic Prospects of Medicinal Plants

Journal of Inflammation Research, Год журнала: 2024, Номер Volume 17, С. 7819 - 7835

Опубликована: Окт. 1, 2024

Sepsis is a common critical illness characterized by high mortality rates and significant disease burden. In the context of sepsis-induced organ dysfunction, lungs are among initial organs affected, which may progress to acute lung injury (ALI) respiratory distress syndrome (ARDS). Recent studies have highlighted crucial roles mitophagy ferroptosis in development progression ALI/ARDS. Identifying key convergence points these processes provide valuable insights for treatment this condition. recent years, certain herbs their bioactive compounds demonstrated unique benefits managing ALI/ARDS modulating or ferroptosis. This review summary mechanisms ferroptosis, explores interactions, emphasizes regulatory Additionally, it offers novel perspective on strategies summarizing various relevant

Язык: Английский

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Compression force regulates cementoblast mineralization via S1PR1/mitophagy axis

The FASEB Journal, Год журнала: 2025, Номер 39(5)

Опубликована: Март 4, 2025

Abstract Orthodontically induced inflammatory root resorption (OIIRR) poses a significant clinical challenge, as excessive orthodontic force shortens tooth longevity by impairing cementoblast‐mediated cementum mineralization and promoting resorption. Cementoblasts, essential for mineralized formation resistance to resorption, exhibit altered mechanosensitivity mechanotransduction under force, yet the role of mitophagy in this process remains poorly understood. In study, we investigated how S1PR1/mitophagy axis modulates cementoblast OIIRR progression. The vivo loading model revealed that heavy compression triggered impaired along with suppression cementoblasts downregulating PINK1 PARKIN expression. vitro experiments further confirmed increased reactive oxygen species (ROS) levels, disrupted mitochondrial membrane potential (MMP), inhibited OCCM30 cells, thereby their capacity. Mechanistically, S1PR1 upregulation activated mitophagy, which turn restored force. Moreover, pharmacological activation SEW2871 alleviated vivo. These findings highlight pivotal maintaining function offering novel insights into molecular mechanisms underlying suggesting therapeutic strategies prevent during treatment.

Язык: Английский

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Ferroptosis and hyperoxic lung injury: insights into pathophysiology and treatment approaches

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Март 18, 2025

Hyperoxia therapy is a critical clinical intervention for both acute and chronic illnesses. However, prolonged exposure to high-concentration oxygen can cause lung injury. The mechanisms of hyperoxic injury (HLI) remain incompletely understood, current treatment options are limited. Improving the safety hyperoxia has thus become an urgent priority. Ferroptosis, novel form regulated cell death characterized by iron accumulation excessive lipid peroxidation, been implicated in pathogenesis HLI, including diffuse alveolar damage, vascular endothelial injury, bronchopulmonary dysplasia. In this review, we analyze latest findings on ferroptosis therapeutic strategies HLI. Our aim provide new insights HLI facilitate translation these from bench bedside.

Язык: Английский

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Exploring the pathogenesis of sepsis-induced cardiomyopathy: Multilayered mechanisms and clinical responses

Science Progress, Год журнала: 2025, Номер 108(1)

Опубликована: Янв. 1, 2025

Sepsis-induced cardiomyopathy (SIC), as a common complication in the intensive care unit, not only increases complexity of patient but also greatly enhances risk death. Currently, clinical management SIC remains challenging, mainly due to its pathogenesis and lack targeted therapies. Although specific etiology is yet fully understood, existing studies have revealed several vital pathological processes that are intertwined contribute progression disease. This narrative review summarizes SIC, which involves multiple aspects including inflammatory response, mitochondrial dysfunction, cell death mechanisms, immune regulation, calcium homeostasis imbalance. Given multifactorial future need explore interactions between these mechanisms how intervene develop more precise effective therapeutic strategies reduce mortality improve prognosis patients with SIC.

Язык: Английский

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Wogonin attenuates septic cardiomyopathy by suppressing ALOX15-mediated ferroptosis

Acta Pharmacologica Sinica, Год журнала: 2025, Номер unknown

Опубликована: Апрель 9, 2025

Язык: Английский

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Natural products and ferroptosis: A novel approach for heart failure management

Phytomedicine, Год журнала: 2025, Номер 142, С. 156783 - 156783

Опубликована: Апрель 18, 2025

Язык: Английский

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