Animals,
Год журнала:
2025,
Номер
15(3), С. 444 - 444
Опубликована: Фев. 6, 2025
This
literature
review
explores
the
impact
of
molecular,
genetic,
and
environmental
factors
on
efficacy
targeted
therapies
in
veterinary
medicine.
Relevant
studies
were
identified
through
systematic
searches
PubMed,
Web
Science,
Scopus,
ScienceDirect
using
keywords
such
as
“species-specific
treatment
strategies”,
“signalling
pathways”,
“epigenetic
paragenetic
influences”,
“targeted
therapies”,
“veterinary
medicine”,
“genetic
variation”,
“free
radicals
oxidative
stress”.
Inclusion
criteria
included
focusing
species-specific
therapeutic
responses,
genetic
influences,
stress.
To
ensure
that
only
most
recent
relevant
evidence
was
included,
peer-reviewed
publications
from
last
two
decades
considered.
Each
study
selected
for
analysis
critically
appraised,
with
a
particular
emphasis
methodological
quality,
experimental
design,
scientific
contribution
to
understanding
how
biological
influence
outcomes.
A
special
placed
used
comparative,
cross-species
approach
assess
variability
responses
potential
adverse
effects.
The
synthesises
role
epigenetic
highlights
importance
understand
By
highlighting
variation,
stress,
individual
species
differences,
argues
personalised
approaches.
emphasises
an
would
improve
care
inform
future
research
aimed
at
optimising
therapies,
ultimately
leading
better
animal
health
efficacy.
key
is
its
need
more
protocols
take
into
account
profiles
factors;
it
also
calls
greater
integration
studies.
Life Sciences,
Год журнала:
2024,
Номер
352, С. 122899 - 122899
Опубликована: Июль 9, 2024
This
comprehensive
review
provides
an
in-depth
analysis
of
how
nanotechnology
has
revolutionized
cancer
theragnostic,
which
combines
diagnostic
and
therapeutic
methods
to
customize
treatment.
The
study
examines
the
unique
attributes,
uses,
difficulties
linked
different
types
nanoparticles,
including
gold,
iron
oxide,
silica,
Quantum
dots,
Carbon
nanotubes,
liposomes,
in
context
In
addition,
paper
progression
nanotheranostics,
emphasizing
its
uses
precise
medication
administration,
photothermal
therapy,
sophisticated
such
as
MRI,
CT,
fluorescence
imaging.
Moreover,
article
highlights
capacity
nanoparticles
improve
effectiveness
drugs,
reduce
overall
toxicity
body,
open
up
new
possibilities
for
treating
by
releasing
drugs
a
controlled
manner
targeting
specific
areas.
Furthermore,
it
tackles
concerns
regarding
compatibility
their
potential
harmful
effects,
significance
continuous
nanotherapeutic
use
medical
treatments.
finishes
outlining
future
applications
predictive
oncology
customized
medicine.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(11), С. 5842 - 5842
Опубликована: Май 27, 2024
This
study
provides
a
brief
discussion
of
the
major
nanopharmaceuticals
formulations
as
well
impact
nanotechnology
on
future
pharmaceuticals.
Effective
and
eco-friendly
strategies
biofabrication
are
also
highlighted.
Modern
approaches
to
designing
pharmaceutical
nanoformulations
(e.g.,
3D
printing,
Phyto-Nanotechnology,
Biomimetics/Bioinspiration,
etc.)
outlined.
paper
discusses
need
use
natural
resources
for
“green”
design
new
with
therapeutic
efficiency.
Nanopharmaceuticals
research
is
still
in
its
early
stages,
preparation
nanomaterials
must
be
carefully
considered.
Therefore,
safety
long-term
effects
not
overlooked.
The
testing
represents
an
essential
point
their
further
applications.
Vegetal
scaffolds
obtained
by
decellularizing
plant
leaves
represent
valuable,
bioinspired
model
nanopharmaceutical
that
avoids
using
animals.
Nanoformulations
critical
various
fields,
especially
pharmacy,
medicine,
agriculture,
material
science,
due
unique
properties
advantages
over
conventional
allows
improved
solubility,
bioavailability,
targeted
drug
delivery,
controlled
release,
reduced
toxicity.
have
transitioned
from
experimental
stages
being
vital
component
clinical
practice,
significantly
improving
outcomes
medical
fields
cancer
treatment,
infectious
diseases,
neurological
disorders,
personalized
advanced
diagnostics.
Here
key
points
highlighting
importance.
significant
challenges,
opportunities,
directions
mentioned
final
section.
ACS Omega,
Год журнала:
2025,
Номер
10(1), С. 1207 - 1225
Опубликована: Янв. 3, 2025
Manufacturing
bioactive
materials
for
drug
delivery
involves
developing
that
interact
with
biological
tissues
to
release
drugs
in
a
controlled
and
targeted
manner.
The
goal
is
optimize
therapeutic
efficacy
reduce
side
effects
by
combining
knowledge
from
engineering,
biology,
pharmacology.
This
study
presents
detailed
bibliometric
analysis,
exploring
the
keywords
"manufacturing,"
"bioactive
materials,"
"drug
delivery"
identify
highlight
significant
advancements
field.
From
Web
of
Science,
36,504
articles
were
analyzed,
171
selected
deeper
identifying
key
journals,
countries,
institutions,
authors.
results
field's
interdisciplinary
nature,
grouped
into
four
main
themes,
including
regenerative
medicine,
scaffolds,
three-dimensional
(3D)
printing,
glass,
tissue
engineering.
Future
research
this
area
will
focus
on
more
effective
precise
systems
using
technologies
like
3D
printing
nanotechnology
enhance
customization
control
release,
aiming
efficient
therapies.
Journal of Functional Biomaterials,
Год журнала:
2025,
Номер
16(1), С. 24 - 24
Опубликована: Янв. 14, 2025
Autoimmune
diseases
present
complex
therapeutic
challenges
due
to
their
chronic
nature,
systemic
impact,
and
requirement
for
precise
immunomodulation
avoid
adverse
side
effects.
Recent
advancements
in
biodegradable
stimuli-responsive
nanomaterials
have
opened
new
avenues
targeted
drug
delivery
systems
capable
of
addressing
these
challenges.
This
review
provides
a
comprehensive
analysis
state-of-the-art
nanocarriers
such
as
polymeric
nanoparticles,
liposomes,
hydrogels
engineered
autoimmune
therapies.
These
are
designed
degrade
safely
the
body
while
releasing
agents
response
specific
stimuli,
including
pH,
temperature,
redox
conditions,
enzymatic
activity.
By
achieving
localized
controlled
release
anti-inflammatory
immunosuppressive
agents,
minimize
toxicity
enhance
efficacy.
We
discuss
underlying
mechanisms
nanomaterials,
recent
applications
treating
rheumatoid
arthritis,
multiple
sclerosis,
inflammatory
bowel
disease,
design
considerations
essential
clinical
translation.
Additionally,
we
address
current
challenges,
biocompatibility,
scalability,
regulatory
hurdles,
well
future
directions
integrating
advanced
nanotechnology
with
personalized
medicine
treatment.
highlights
transformative
potential
presenting
them
promising
strategy
advance
precision
improve
patient
outcomes
disease
management.
Materials Today Bio,
Год журнала:
2025,
Номер
31, С. 101626 - 101626
Опубликована: Март 1, 2025
Cancer
treatment
is
challenged
by
the
tumor
microenvironment
(TME),
which
promotes
drug
resistance
and
cancer
cell
growth.
This
review
offers
a
comprehensive
innovative
perspective
on
how
nanomedicine
can
modify
TME
to
enhance
therapy.
Strategies
include
using
nanoparticles
improve
oxygenation,
adjust
acidity,
alter
extracellular
matrix,
making
treatments
more
effective.
Additionally,
immune
responses
activating
cells
reducing
suppression
within
tumors.
By
integrating
these
approaches
with
existing
therapies,
such
as
chemotherapy
radiotherapy,
show
promise
in
overcoming
traditional
barriers.
The
discusses
changes
effectiveness
of
itself,
creating
reciprocal
relationship
that
boosts
overall
efficacy.
We
also
highlight
novel
strategies
aimed
at
exploiting
TME,
leveraging
nanoparticle-based
for
targeted
therapy
through
precise
modulation.
Journal of Clinical Medicine,
Год журнала:
2024,
Номер
13(21), С. 6537 - 6537
Опубликована: Окт. 30, 2024
Next-generation
immunotherapies
have
revolutionized
cancer
treatment,
offering
hope
for
patients
with
hard-to-treat
tumors.
This
review
focuses
on
the
clinical
applications
and
advancements
of
key
immune-based
therapies,
including
immune
checkpoint
inhibitors,
CAR-T
cell
therapy,
new
vaccines
designed
to
harness
system
combat
malignancies.
A
prime
example
is
success
pembrolizumab
in
treatment
advanced
melanoma,
underscoring
transformative
impact
these
therapies.
Combination
treatments,
integrating
immunotherapy
chemotherapy,
radiation,
targeted
are
demonstrating
synergistic
benefits
improving
patient
outcomes.
also
explores
evolving
role
personalized
immunotherapy,
guided
by
biomarkers,
genomic
data,
tumor
environment,
better
target
individual
Although
significant
progress
has
been
made,
challenges
such
as
resistance,
side
effects,
high
costs
persist.
Technological
innovations,
nanotechnology
artificial
intelligence,
explored
future
enablers
The
evaluates
trials,
breakthroughs,
emerging
immune-modulating
agents
delivery
systems
that
hold
great
promise
enhancing
efficacy,
reducing
toxicity,
expanding
access
immunotherapy.
In
conclusion,
this
highlights
ongoing
reshaping
care,
strategies
poised
overcome
current
further
extend
therapeutic
reach.
Expert Opinion on Drug Delivery,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 8, 2024
Applying
artificial
intelligence
(AI)
to
nanomedicine
has
greatly
increased
the
production
of
specially
engineered
nanoscale
materials
for
tailored
medicine,
marking
a
significant
advancement
in
healthcare.
With
use
AI,
researchers
can
search
through
massive
databases
and
find
nano-properties
that
support
range
therapeutic
objectives,
eventually
producing
safer,
customized
nanomaterials.
AI
analyzes
patient
data,
including
clinical
genetic
information,
predict
results
individualized
care
makes
recommendations
therapy
improvement.
Furthermore,
logically
creates
nanocarriers
give
precise
controlled
drug
release
patterns
optimize
advantages
minimize
undesirable
side
effects.
Even
though
lot
potential
nanomedicine,
there
are
still
issues
data
integration
techniques,
moral
dilemmas,
requirement
governmental
backing.
Future
developments
tools
multidisciplinary
cooperation
between
scientists
with
expertise
biological
sciences
nanoengineering
essential
nanomedicine.
Together,
these
disciplines
propel
advancements
precision
contributing
ultimate
objective—a
future
which
combine
provide
really
The
authors
this
editorial
encourage
call
on
scientists,
physicians,
legislators
acknowledge
its
transform
treatment.
