Anticancer Potential and Molecular Targets of Pristimerin in Human Malignancies DOI Creative Commons

Kirti S. Prabhu,

Serah Jessy,

Shilpa Kuttikrishnan

и другие.

Pharmaceuticals, Год журнала: 2024, Номер 17(5), С. 578 - 578

Опубликована: Апрель 30, 2024

The growing global burden of malignant tumors with increasing incidence and mortality rates underscores the urgent need for more effective less toxic therapeutic options. Herbal compounds are being increasingly studied their potential to meet these needs due reduced side effects significant efficacy. Pristimerin (PS), a triterpenoid from quinone formamide class derived Celastraceae Hippocrateaceae families, has emerged as potent anticancer agent. It exhibits broad-spectrum anti-tumor activity across various cancers such breast, pancreatic, prostate, glioblastoma, colorectal, cervical, lung cancers. PS modulates several key cellular processes, including apoptosis, autophagy, cell migration invasion, angiogenesis, resistance chemotherapy, targeting crucial signaling pathways those involving NF-κB, p53, STAT3, among others. main objective this review is provide comprehensive synthesis current literature on PS, emphasizing its mechanisms action molecular targets utmost clarity. discusses comparative advantages over cancer therapies explores implications future research clinical applications. By delineating specific affected by seeks offer valuable insights directions in field. information gathered could pave way successful development into clinically applicable therapy.

Язык: Английский

Anticancer Potential and Molecular Targets of Pristimerin in Human Malignancies DOI Creative Commons

Kirti S. Prabhu,

Serah Jessy,

Shilpa Kuttikrishnan

и другие.

Pharmaceuticals, Год журнала: 2024, Номер 17(5), С. 578 - 578

Опубликована: Апрель 30, 2024

The growing global burden of malignant tumors with increasing incidence and mortality rates underscores the urgent need for more effective less toxic therapeutic options. Herbal compounds are being increasingly studied their potential to meet these needs due reduced side effects significant efficacy. Pristimerin (PS), a triterpenoid from quinone formamide class derived Celastraceae Hippocrateaceae families, has emerged as potent anticancer agent. It exhibits broad-spectrum anti-tumor activity across various cancers such breast, pancreatic, prostate, glioblastoma, colorectal, cervical, lung cancers. PS modulates several key cellular processes, including apoptosis, autophagy, cell migration invasion, angiogenesis, resistance chemotherapy, targeting crucial signaling pathways those involving NF-κB, p53, STAT3, among others. main objective this review is provide comprehensive synthesis current literature on PS, emphasizing its mechanisms action molecular targets utmost clarity. discusses comparative advantages over cancer therapies explores implications future research clinical applications. By delineating specific affected by seeks offer valuable insights directions in field. information gathered could pave way successful development into clinically applicable therapy.

Язык: Английский

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