Obesity-Induced PVAT Dysfunction and Atherosclerosis Development: The Role of GHSR-1a in Increased Macrophage Infiltration and Adipocytokine Secretion
Journal of Cardiovascular Development and Disease,
Год журнала:
2025,
Номер
12(3), С. 87 - 87
Опубликована: Фев. 26, 2025
In
obesity,
recent
research
revealed
that
increased
expression
of
the
growth
hormone
secretagogue
receptor
(GHSR)
in
macrophages
plays
a
pivotal
role
development
meta-inflammation,
promoting
macrophage
infiltration
and
pro-inflammatory
polarization.
This
study
aimed
to
examine
association
between
GHSR-1a
atherosclerotic
plaques
adjacent
perivascular
adipose
tissue
(PVAT)
from
11
patients
with
obesity
peripheral
artery
disease
(PAD)
who
underwent
revascularization
procedures.
Immunohistochemistry
was
used
assess
CD68,
CD80,
CD14,
while
homogenate
levels
adiponectin,
leptin,
IL-6,
CRP
were
quantified
via
ELISA.
Serum
markers
inflammation
also
measured.
Among
GHSR-1a-positive
(+)
plaques,
we
observed
significantly
higher
white
blood
cell
counts
platelet-to-lymphocyte
ratios
serum,
lower
adiponectin-to-leptin
ratio,
elevated
IL-6
both
arterial
PVAT
homogenates.
Our
findings
suggest
link
macrophage/monocyte
infiltration,
polarization,
adipocytokine
secretion
associated
obesity-induced
dysfunction.
Язык: Английский
C-C chemokine ligand 5 from subcutaneous adipose tissue has a central role in vascular aging
Research Square (Research Square),
Год журнала:
2025,
Номер
unknown
Опубликована: Март 31, 2025
Abstract
Background:
Aging
is
associated
with
adipose
tissue
alterations,
oxidative
stress,
and
fibrosis
together
the
onset
of
cardiometabolic
complications
such
as
atherosclerosis.
Although
it
has
been
shown
that
perivascular
(PVAT)
can
participate
to
vascular
damage,
involvement
subcutaneous
(SCAT)
-
particularly
through
its
secretory
activity
in
aging
remains
poorly
understood.
We
have
previously
human
adipose-derived
stromal
cells
(ASCs)
from
SCAT
aged
women
display
senescence
stress.
hypothesized
ASC
secretome
contributes
endothelial
dysfunction,
an
early
stage
aging.
Methods:
Conditioned
media
were
prepared
ASCs
isolated
healthy
young
(<25y)
or
(>60y)
women.
The
was
analysed
added
on
coronary
artery
(HCAEC).
Using
clinical
cohorts,
we
evaluated
expression
C-C-chemokine-ligand-5
(CCL5)/Regulated
upon
Activation
Normally
T-expressed
secreted
(RANTES)
individuals
heart
disease.
Results:
aged-donor
induced
cell
dysfunction
HCAEC,
characterized
by
lower
nitric
oxide
production,
higher
(greater
p16
expression),
a
pro-adherent
phenotype
(elevated
adhesion
molecule
secretion).
Aged-donor
also
favored
Endothelial-to-mesenchymal
transition,
characterised
mesenchymal
markers
pro-migratory
profile.
showed
CCL5/RANTES
at
level
aged-
vs.
young-donor
responsible
for
these
effects.
Accordingly,
SCAT,
but
not
epicardial
tissue,
blood
pressure
patients
diseases,
thus
confirming
important
role
disorders.
Moreover,
both
HCAEC
cohort
receptor
antagonist
drug
maraviroc
prevented
deleterious
impact
CCL5/RANTES.
Conclusions:
Our
results
highlighted
ability
released
and,
specifically,
cells,
induce
which
are
steps
potential
link
between
phenomena
hypertension
particular.
Язык: Английский
Sex-Specific Characteristics of Perivascular Fat in Aortic Aneurysms
Journal of Clinical Medicine,
Год журнала:
2025,
Номер
14(9), С. 3071 - 3071
Опубликована: Апрель 29, 2025
Aortic
aneurysms
(AAs),
the
dilation
or
widening
of
aorta,
lead
to
dissection
rupture
with
high
morbidity
and
mortality
if
untreated.
AA
displays
gender
disparities
in
its
prevalence,
progression
outcomes,
women
having
worse
outcomes
faster
aneurysm
growth.
However,
current
guidelines
do
not
address
dimorphism,
emphasizing
urgent
need
for
personalized
treatment
strategies
further
research.
Perivascular
adipose
tissue
(PVAT),
a
unique
type
fat
surrounding
blood
vessels,
plays
critical
role
maintaining
vasomotor
tone
vascular
homeostasis,
dysfunction
associated
chronic
inflammation
vessel-wall
remodeling.
Indeed,
PVAT
promotes
development
aortic
aneurysms,
hormonal
biomechanical
factors
exacerbating
pathological
microenvironment.
The
sexually
dimorphic
characteristics
include
morphological,
immunological,
hormonally
mediated
differences.
Thus,
targeting
PVAT-mediated
mechanisms
may
be
promising
option
(gender-specific)
therapeutic
management
cardiovascular
pathologies.
This
review
examines
emerging
importance
health,
potential
implications
AA,
identifies
gaps
state
Язык: Английский
Impact of the local renin–angiotensin system in perivascular adipose tissue on vascular health and disease
Cellular Signalling,
Год журнала:
2024,
Номер
124, С. 111461 - 111461
Опубликована: Окт. 9, 2024
Язык: Английский
Vascular aging: the role of hypertension, obesity and meta-inflammation
Arterial’naya Gipertenziya (Arterial Hypertension),
Год журнала:
2024,
Номер
30(6), С. 553 - 561
Опубликована: Дек. 29, 2024
Cardiovascular
diseases
are
the
main
cause
of
disability
and
mortality
in
elderly
population
developed
countries.
At
same
time,
population-based
studies
have
shown
that
aging
remains
most
significant
risk
factor
for
cardiovascular
pathology.
Existing
geroprotection
strategies
not
high
efficiency.
mechanisms
negative
impact
known
factors
(such
as
hypertension,
obesity,
metabolic
disorders)
largely
identical
to
processes
aging.Pathophysiological
associated
with
include
oxidative
stress
mitochondrial
dysfunction,
impaired
autophagy
increased
apoptosis,
telomere
meta-inflammation
fibrosis.
They
interconnected
potentiated
by
presence
hypertension
aggravating
provoking
atherogenesis.Understanding
key
common
links
pathogenesis
these
will
help
determine
direction
developing
more
effective
prevention
Язык: Английский