Vascular aging: the role of hypertension, obesity and meta-inflammation DOI Open Access
I. V. Zyubanova, V. Mordovin, V. Lichikaki

и другие.

Arterial’naya Gipertenziya (Arterial Hypertension), Год журнала: 2024, Номер 30(6), С. 553 - 561

Опубликована: Дек. 29, 2024

Cardiovascular diseases are the main cause of disability and mortality in elderly population developed countries. At same time, population-based studies have shown that aging remains most significant risk factor for cardiovascular pathology. Existing geroprotection strategies not high efficiency. mechanisms negative impact known factors (such as hypertension, obesity, metabolic disorders) largely identical to processes aging.Pathophysiological associated with include oxidative stress mitochondrial dysfunction, impaired autophagy increased apoptosis, telomere meta-inflammation fibrosis. They interconnected potentiated by presence hypertension aggravating provoking atherogenesis.Understanding key common links pathogenesis these will help determine direction developing more effective prevention

Язык: Английский

Obesity-Induced PVAT Dysfunction and Atherosclerosis Development: The Role of GHSR-1a in Increased Macrophage Infiltration and Adipocytokine Secretion DOI Creative Commons

Sorin Nicolae Peiu,

Florin Zugun‐Eloae,

Bogdan Stoica

и другие.

Journal of Cardiovascular Development and Disease, Год журнала: 2025, Номер 12(3), С. 87 - 87

Опубликована: Фев. 26, 2025

In obesity, recent research revealed that increased expression of the growth hormone secretagogue receptor (GHSR) in macrophages plays a pivotal role development meta-inflammation, promoting macrophage infiltration and pro-inflammatory polarization. This study aimed to examine association between GHSR-1a atherosclerotic plaques adjacent perivascular adipose tissue (PVAT) from 11 patients with obesity peripheral artery disease (PAD) who underwent revascularization procedures. Immunohistochemistry was used assess CD68, CD80, CD14, while homogenate levels adiponectin, leptin, IL-6, CRP were quantified via ELISA. Serum markers inflammation also measured. Among GHSR-1a-positive (+) plaques, we observed significantly higher white blood cell counts platelet-to-lymphocyte ratios serum, lower adiponectin-to-leptin ratio, elevated IL-6 both arterial PVAT homogenates. Our findings suggest link macrophage/monocyte infiltration, polarization, adipocytokine secretion associated obesity-induced dysfunction.

Язык: Английский

Процитировано

0

C-C chemokine ligand 5 from subcutaneous adipose tissue has a central role in vascular aging DOI Creative Commons
Laura Pelletier,

Kenza Ngono Ayissi,

Émilie Capel

и другие.

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Март 31, 2025

Abstract Background: Aging is associated with adipose tissue alterations, oxidative stress, and fibrosis together the onset of cardiometabolic complications such as atherosclerosis. Although it has been shown that perivascular (PVAT) can participate to vascular damage, involvement subcutaneous (SCAT) - particularly through its secretory activity in aging remains poorly understood. We have previously human adipose-derived stromal cells (ASCs) from SCAT aged women display senescence stress. hypothesized ASC secretome contributes endothelial dysfunction, an early stage aging. Methods: Conditioned media were prepared ASCs isolated healthy young (<25y) or (>60y) women. The was analysed added on coronary artery (HCAEC). Using clinical cohorts, we evaluated expression C-C-chemokine-ligand-5 (CCL5)/Regulated upon Activation Normally T-expressed secreted (RANTES) individuals heart disease. Results: aged-donor induced cell dysfunction HCAEC, characterized by lower nitric oxide production, higher (greater p16 expression), a pro-adherent phenotype (elevated adhesion molecule secretion). Aged-donor also favored Endothelial-to-mesenchymal transition, characterised mesenchymal markers pro-migratory profile. showed CCL5/RANTES at level aged- vs. young-donor responsible for these effects. Accordingly, SCAT, but not epicardial tissue, blood pressure patients diseases, thus confirming important role disorders. Moreover, both HCAEC cohort receptor antagonist drug maraviroc prevented deleterious impact CCL5/RANTES. Conclusions: Our results highlighted ability released and, specifically, cells, induce which are steps potential link between phenomena hypertension particular.

Язык: Английский

Процитировано

0

Sex-Specific Characteristics of Perivascular Fat in Aortic Aneurysms DOI Open Access

Katja Heller,

Panagiotis Doukas, Christian Uhl

и другие.

Journal of Clinical Medicine, Год журнала: 2025, Номер 14(9), С. 3071 - 3071

Опубликована: Апрель 29, 2025

Aortic aneurysms (AAs), the dilation or widening of aorta, lead to dissection rupture with high morbidity and mortality if untreated. AA displays gender disparities in its prevalence, progression outcomes, women having worse outcomes faster aneurysm growth. However, current guidelines do not address dimorphism, emphasizing urgent need for personalized treatment strategies further research. Perivascular adipose tissue (PVAT), a unique type fat surrounding blood vessels, plays critical role maintaining vasomotor tone vascular homeostasis, dysfunction associated chronic inflammation vessel-wall remodeling. Indeed, PVAT promotes development aortic aneurysms, hormonal biomechanical factors exacerbating pathological microenvironment. The sexually dimorphic characteristics include morphological, immunological, hormonally mediated differences. Thus, targeting PVAT-mediated mechanisms may be promising option (gender-specific) therapeutic management cardiovascular pathologies. This review examines emerging importance health, potential implications AA, identifies gaps state

Язык: Английский

Процитировано

0

Impact of the local renin–angiotensin system in perivascular adipose tissue on vascular health and disease DOI
Pitchai Balakumar, Khalid Orayj, Noohu Abdulla Khan

и другие.

Cellular Signalling, Год журнала: 2024, Номер 124, С. 111461 - 111461

Опубликована: Окт. 9, 2024

Язык: Английский

Процитировано

2

Vascular aging: the role of hypertension, obesity and meta-inflammation DOI Open Access
I. V. Zyubanova, V. Mordovin, V. Lichikaki

и другие.

Arterial’naya Gipertenziya (Arterial Hypertension), Год журнала: 2024, Номер 30(6), С. 553 - 561

Опубликована: Дек. 29, 2024

Cardiovascular diseases are the main cause of disability and mortality in elderly population developed countries. At same time, population-based studies have shown that aging remains most significant risk factor for cardiovascular pathology. Existing geroprotection strategies not high efficiency. mechanisms negative impact known factors (such as hypertension, obesity, metabolic disorders) largely identical to processes aging.Pathophysiological associated with include oxidative stress mitochondrial dysfunction, impaired autophagy increased apoptosis, telomere meta-inflammation fibrosis. They interconnected potentiated by presence hypertension aggravating provoking atherogenesis.Understanding key common links pathogenesis these will help determine direction developing more effective prevention

Язык: Английский

Процитировано

0