Noncoding RNA-encoded peptides in cancer: biological functions, posttranslational modifications and therapeutic potential
Journal of Hematology & Oncology,
Год журнала:
2025,
Номер
18(1)
Опубликована: Фев. 19, 2025
In
the
present
era,
noncoding
RNAs
(ncRNAs)
have
become
a
subject
of
considerable
scientific
interest,
with
peptides
encoded
by
ncRNAs
representing
particularly
promising
avenue
investigation.
The
identification
ncRNA-encoded
in
human
cancers
is
increasing.
These
regulate
cancer
progression
through
multiple
molecular
mechanisms.
Here,
we
delineate
patterns
diverse
and
provide
synopsis
methodologies
employed
for
that
possess
capacity
to
encode
these
peptides.
Furthermore,
discuss
impacts
on
biological
behavior
cells
underlying
conclusion,
describe
prospects
challenges
need
be
overcome.
Язык: Английский
Effects of circulating RNAs on tumor metabolism in lung cancer (Review)
Oncology Letters,
Год журнала:
2025,
Номер
29(4), С. 1 - 11
Опубликована: Фев. 27, 2025
During
the
development
and
progression
of
lung
cancer,
cell
metabolism
function
is
altered.
Thus,
cells
rely
on
aerobic
glycolysis
abnormal
lipid
amino
acid
to
obtain
energy
nutrients
for
growth,
proliferation
drug
resistance.
Circular
RNAs
(circRNAs),
a
class
non-coding
RNAs,
serve
important
biological
roles
in
growth
tumors.
Functionally,
circRNAs
act
as
molecular
sponges
that
absorb
microRNAs
(miRNAs)
RNA-binding
proteins
protein
scaffolds
regulate
gene
transcription
translation
through
maintenance
mRNA
stability.
In
addition,
are
regulators
tumor
promote
mediating
proliferation,
metastasis
induction
chemoresistance.
Results
previous
studies
reveal
may
key
role
regulating
metabolic
processes
miRNA
sponging
alternative
mechanisms.
demonstrate
potential
therapeutic
targets
cancer.
The
present
study
aimed
review
effects
cancer
provide
novel
insights
into
clinical
treatment
also
theoretical
basis
targets.
Язык: Английский
EVA1B facilitates esophageal squamous carcinoma progression and recruitment of immunosuppressive myeloid-derived suppressor cells in the tumor microenvironment
Pharmacological Research,
Год журнала:
2024,
Номер
unknown, С. 107521 - 107521
Опубликована: Ноя. 1, 2024
Язык: Английский
Breast cancer spheroids prefer activated macrophages as an accomplice: An in vitro study
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 25, 2024
Abstract
Cancer,
a
heterogeneous
disease
in
nature,
often
requires
help
from
diverse
pro-tumor
or
tumor-associated-
cells,
which
are
recruited
and
persevered
within
the
stroma.
Pro-tumor
stromal
cells
provide
essential
support
needed
for
tumor
growth,
metastasis,
development
of
drug
resistance
due
time.
Tumor-associated
macrophages,
one
such
to
microenvironment
survival.
In
recent
years,
TAMs
have
been
identified
as
potential
targets
therapeutic
agents,
encourages
in-depth
characterization
their
crosstalk
with
tumors.
The
current
study
has
successfully
developed
cost-effective
vitro
platform
Chemokine
Assisted
Recruitment
Macrophages
spheroids
mimicking
physiology
TAM
recruitment.
Firstly,
monocytic
cell
line
(U937)
were
converted
into
activated
naive
macrophages
(M0)
pro-and
anti-inflammatory
(M1
M2)
subtypes.
Monocytes,
M0,
M1,
M2
characterized
extensively.
Secondly,
polarized
subjected
chemokine-dependent
recruitment
monotypic
heterotypic
breast
cancer
spheroids.
nature
is
further
investigated
by
assessing
profile
chemokines
chemokine
receptors.
Recruited
also
observed
manipulate
spheroid
behavior
many
ways.
exhibit
an
increased
level
Siglec-1
(CD169),
markers.
platform’s
application
can
be
extended
understand
process
other
immune/stromal
solid
It
could
addition
arrays
platforms
screen
efficiency
cell-based
immunotherapeutics
future.
Язык: Английский