Exploring viral mimicry combined with epigenetics and tumor immunity: new perspectives in cancer therapy
International Journal of Biological Sciences,
Год журнала:
2025,
Номер
21(3), С. 958 - 973
Опубликована: Янв. 6, 2025
Viral
mimicry
refers
to
an
active
antiviral
response
triggered
by
the
activation
of
endogenous
retroviruses
(ERVs),
usually
manifested
formation
double-stranded
RNA
(dsRNA)
and
cellular
interferon
response,
which
activates
immune
system
produces
anti-tumor
effects.
Epigenetic
studies
have
shown
that
epigenetic
modifications
(e.g.
DNA
methylation,
histone
modifications,
etc.)
play
a
crucial
role
in
tumorigenesis,
progression,
treatment
resistance.
Particularly,
alterations
methylation
may
be
closely
associated
with
suppression
ERVs
expression,
demethylation
restore
activity
thus
strengthen
tumor
response.
Therefore,
we
propose
viral
can
induce
responses
microenvironment
activating
expression
ERVs,
key
regulatory
this
process.
In
paper,
review
intersection
mimicry,
epigenetics
immunotherapy,
explore
possible
interactions
synergistic
effects
among
three,
aiming
provide
new
theoretical
basis
potential
strategies
for
cancer
immunotherapy.
Язык: Английский
Research progress of DNA methylation in the diagnosis and treatment of thyroid carcinoma
International Immunopharmacology,
Год журнала:
2025,
Номер
152, С. 114426 - 114426
Опубликована: Март 9, 2025
Thyroid
cancer
is
the
most
prevalent
endocrine
malignancy,
and
its
timely
accurate
diagnostic
prognostic
assessments
are
crucial
for
enhancing
patient
survival
rates.
As
an
important
epigenetic
modification,
DNA
methylation
plays
a
key
role
in
regulation
of
gene
expression
tumorigenesis.
Recent
studies
increasingly
indicate
that
abnormal
patterns
closely
associated
with
onset
progression
thyroid
cancer.
This
review
discusses
diagnosing
adenocarcinoma,
impact
on
prognosis,
potential
utility
immunotherapy.
Additionally,
it
explores
prospect
using
as
biomarker
highlights
significant
personalized
treatment
article
aims
to
serve
resource
future
research
clinical
applications
advance
diagnosis
Язык: Английский
Insight into the role of DNA methylation in prognosis and treatment response prediction of gastrointestinal cancers
Epigenomics,
Год журнала:
2025,
Номер
unknown, С. 1 - 14
Опубликована: Март 14, 2025
Gastrointestinal
(GI)
cancers
impose
a
significant
disease
burden,
underscoring
the
critical
importance
of
accurate
prognosis
prediction
and
treatment
response
evaluation.
DNA
methylation,
one
most
extensively
studied
epigenetic
modifications,
has
gained
prominence
due
to
its
reliable
measurement
across
various
sample
types.
Numerous
studies
have
reported
that
methylation
was
linked
diagnosis,
in
malignancies,
including
GI
cancers.
While
diagnostic
role
been
comprehensively
reviewed.
Recent
research
increasingly
highlighted
potential
However,
no
existing
reviews
exclusively
focused
on
these
two
aspects.
In
this
review,
we
retrieved
relevant
included
230
them
our
discussion,
thereby
providing
an
overview
clinical
applicability
aberrant
fields
among
patients
with
esophageal,
gastric,
colorectal,
pancreatic
cancers,
hepatocellular
carcinomas.
Additionally,
discuss
limitations
current
literature
propose
directions
for
future
research.
Specifically,
emphasize
need
standardized
methodologies
advocate
integration
gene
panels,
rather
than
single
genes,
address
tumor
heterogeneity
more
effectively.
Язык: Английский
Unleashing the Potential of Metal Ions in cGAS-STING Activation: Advancing Nanomaterial-Based Tumor Immunotherapy
Xingyin Li,
Shaojie Xu,
Ziliang Su
и другие.
ACS Omega,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 17, 2025
Immunotherapy
is
a
critical
modality
in
cancer
treatment
with
diverse
activation
pathways.
In
recent
years,
the
stimulator
of
interferon
genes
(STING)
signaling
pathway
has
exhibited
significant
potential
tumor
immunotherapy.
This
exerts
notable
antitumor
effects
by
activating
innate
and
adaptive
immunity
regulating
immune
microenvironment.
Various
metal
ions
have
been
identified
as
effective
activators
STING
and,
through
design
synthesis
nanodelivery
platforms,
applied
immunotherapy
well
combination
therapies,
such
chemotherapy,
chemodynamic
therapy,
photodynamic
vaccines.
Metal
nanomaterials
showcase
unique
advantages
immunotherapy;
however,
there
are
still
aspects
that
require
optimization.
review
systematically
examines
existing
metal-based
nanomaterials,
elaborates
on
mechanisms
which
different
activate
pathway,
discusses
their
application
models
therapies.
We
also
provide
comparative
analysis
over
other
methods.
Our
exploration
highlights
broad
prospects
treatment,
offering
new
insights
directions
for
advancement
Язык: Английский
Uncovering the Effects and Molecular Mechanisms of Shaoyao Decoction Against Colorectal Cancer Using Network Pharmacology Analysis Coupled With Experimental Validation and Gut Microbiota Analysis
Cancer Medicine,
Год журнала:
2025,
Номер
14(6)
Опубликована: Март 1, 2025
ABSTRACT
Background
Chronic
gut
inflammation
and
dysbiosis
contribute
significantly
to
colorectal
cancer
(CRC)
development.
Shaoyao
decoction
(SYD)
is
a
well‐established
Chinese
medicine
prescription.
Besides
ameliorating
CRC
via
anti‐inflammatory
effects,
SYD
modulates
microbiota
(GM)
improve
inflammatory
responses
in
ulcerative
colitis
(UC).
However,
whether
how
suppresses
by
regulating
GM
remains
largely
unknown.
Methods
SD
rats
were
orally
administered
for
7
days
obtain
medicated
serum.
We
utilized
liquid
chromatography–mass
spectrometry
(LC–MS)
analysis,
GeneCards,
DisGeNET,
SwissTargetPrediction
databases
analyze
blank
SYD‐medicated
rat
serum,
comparing
the
findings
with
those
of
aqueous
extract
previous
studies
identify
circulating
compounds/components
predictable
target
genes.
Using
network
pharmacology,
potential
active
compounds
corresponding
hub
genes
associated
modulating
suppress
selected
molecular
docking.
In
vivo
experiments,
transplantation
tumor
model
was
established
BALB/c
mice
using
CT26
cells,
gavage
14
days.
To
investigate
mechanism
SYD‐regulated
against
CRC,
HE
IHC
staining,
Western
blotting,
16S
rRNA
sequencing
employed.
Results
LC–MS
identified
26
computationally
predicted
Network
pharmacology
prioritized
13
targeting
8
inflammation/immunity‐related
(IL‐17/TNF
pathways),
validated
dose‐dependently
suppressed
growth
(
p
<
0.05,
medium/high
doses),
as
confirmed
staining
analysis
Ki‐67.
Notably,
potentially
delayed
liver
metastasis
alleviated
hepatic
injury
tumor‐bearing
mice.
blotting
demonstrated
SYD's
inhibition
IL‐17/TNF/NF‐κB
axis,
aligning
computational
predictions.
revealed
SYD‐enriched
Akkermansia
structural
shifts,
mechanistically
linking
remodeling
anti‐tumor
efficacy.
Conclusions
combats
dual
modulation
signaling
ecosystems
(e.g.,
enrichment).
This
microbiota‐immune
crosstalk
positions
adjunct
conventional
therapies,
particularly
patients
dysbiosis.
Язык: Английский
YEATS2: a novel cancer epigenetic reader and potential therapeutic target
Cancer Cell International,
Год журнала:
2025,
Номер
25(1)
Опубликована: Апрель 26, 2025
YEATS2,
an
evolutionarily
conserved
reader
of
histone
acylation
marks
(H3K27ac,
H3K27cr,
H3K27bz),
functions
as
a
central
oncogenic
driver
in
diverse
cancers,
including
non-small
cell
lung
cancer
(NSCLC),
pancreatic
ductal
adenocarcinoma
(PDAC),
and
hepatocellular
carcinoma
(HCC).
Its
structurally
plastic
YEATS
domain
bridges
acyl-CoA
metabolism
to
chromatin
remodeling,
amplifying
transcription
survival
genes
such
MYC,
BCL2,
PD-L1.
YEATS2
orchestrates
malignancy-specific
programs-sustaining
ribosome
biogenesis
NSCLC
through
ATAC
complex
recruitment,
enhancing
NF-κB-dependent
immune
evasion
PDAC,
activating
PI3K/AKT-driven
metabolic
rewiring
HCC.
Structural
studies
demonstrate
unique
aromatic
cage
architecture
that
selectively
engages
acylated
histones.
Although
pyrazolopyridine-based
inhibitors
targeting
the
show
preclinical
efficacy,
developing
isoform-selective
agents
remains
challenging.
Clinically,
overexpression
correlates
with
therapy
resistance
may
synergize
checkpoint
blockade.
This
review
integrates
mechanistic
insights
into
role
epigenetic
regulation,
evaluates
its
therapeutic
potential,
proposes
future
directions:
elucidating
full-length
topologies,
mapping
synthetic
lethal
interactors,
optimizing
selective
inhibitors.
Disrupting
YEATS2-mediated
adaptation
presents
novel
opportunities
for
precision
therapy.
Язык: Английский
Role of DNA methylation transferase in urinary system diseases: From basic to clinical perspectives (Review)
International Journal of Molecular Medicine,
Год журнала:
2024,
Номер
55(2)
Опубликована: Ноя. 19, 2024
DNA
methylation
is
one
of
the
earliest
discovered
and
most
extensively
studied
epigenetic
regulatory
mechanisms.
Broadly,
refers
to
transfer
a
methyl
group
on
S‑adenosine‑L‑methionine
(SAM)
C5
site
cytosine,
reaction
catalysed
by
methyltransferase
(DNMT).
This
process
can
either
up‑
or
down‑regulate
gene
expression
due
promoter
methylation,
leading
occurrence
certain
diseases.
Urinary
system
diseases,
known
for
their
high
prevalence
complex
pathogenesis,
significantly
affect
lives
health
patients.
Urological
tumours,
in
particular,
represent
non‑negligible
disease
burden
worldwide.
With
development
epigenetics,
an
increasing
number
studies
have
demonstrated
that
DNMT
plays
important
role
urinary
disease.
The
present
review
aims
explore
relationship
between
diseases
potential
clinical
management
these
Язык: Английский