ACS Omega, Год журнала: 2025, Номер unknown
Опубликована: Май 29, 2025
Язык: Английский
Epigenetics Communications, Год журнала: 2025, Номер 5(1)
Опубликована: Янв. 7, 2025
Cardiovascular disease (CVD) is the primary cause of mortality globally with a multifactorial etiology that involves epigenetics. Chromobox 3 (CBX3), major isoform heterochromatin protein 1, involved in intricate epigenetic mechanisms affecting congestive heart failure. In patients CVD affected by lung cancer risk, CBX3 exerts sophisticated mechanism action, suppressing proliferation, migration, and formation neointima vascular smooth muscle cells (VSMCs) Notch3 pathway, indicating potential protective function against remodeling atherosclerosis. However, broader im- pact on endothelial function, as well its effects monocyte/macro- phage lymphocyte infiltration within arterial wall, remain poorly understood. Since very little known so far, more definite research would be needed to reveal fine along relationship molecular processes prospects biomarker. Specifically, biological features could examined gain greater insight into risks. This review outlines role associated feasibility for optimizing pre-existing therapy developing new therapeutic strategies based personalized medicine.
Язык: Английский
Процитировано
0
Biomolecules, Год журнала: 2025, Номер 15(3), С. 439 - 439
Опубликована: Март 19, 2025
Cardiovascular diseases (CVDs), which include multiple disorders of the heart and blood vessels, are leading causes death. Nitric oxide (NO) is a vasodilator that regulates vascular tension. Endogenous NO produced via L-arginine–nitric synthase (NOS) pathway. In conditions cardiovascular dysfunction, NOS activity impaired, to deficiency. turn, reduction in bioactivity exacerbates pathogenesis CVDs. Exogenous intake inorganic nitrate supplements endogenous production nitrate–nitrite–NO pathway maintain supply. Salivary glands play an essential role conversion NO, with approximately 25% circulating being absorbed secreted into saliva. As result, salivary concentrations can exceed by more than tenfold. This recycled saliva serves as reservoir for performs NO-like functions when insufficient. this review, we summarize emerging benefits dietary CVDs, particular focus on salivary-gland-mediated recirculation maintaining bioavailability homeostasis. Salivary-gland-mediated provides novel perspective potential intervention
Язык: Английский
Процитировано
0
Human Genetics, Год журнала: 2025, Номер unknown
Опубликована: Апрель 15, 2025
Transfer RNA-derived small RNAs (tsRNAs) have emerged as potential biomarkers of various human diseases. However, the clinical utility and biological functions tsRNA in acute coronary syndrome (ACS) remain poorly understood. To investigate this, we performed high-throughput RNA sequencing on peripheral blood monocyte cells (PBMCs) from 24 ACS patients 12 healthy controls. Our analysis revealed distinct characteristic expression patterns tsRNAs response to ACS, highlighting their disease signatures PBMCs. Differentially expressed were validated using RT-qPCR two independent case-control sets. Among these, tRF-Gly-GCC-06 was significantly upregulated volunteers with unstable angina (UA) myocardial infarction (AMI) (p < 0.05) showed a statistically significant positive correlation Gensini score (r = 0.353, p 0.001). Moreover, this independently associated an increased risk after adjusting for conventional cardiovascular factors (odds ratio (OR) 1.58, 95% confidence interval (CI): 1.37-1.83, A series functional studies that facilitated macrophage proliferation migration modulated inflammation-related gene vitro. This study identified novel tRF-Gly-GCC-06, biomarker therapeutic target.
Язык: Английский
Процитировано
0
Clinica Chimica Acta, Год журнала: 2025, Номер 576, С. 120405 - 120405
Опубликована: Май 29, 2025
Язык: Английский
Процитировано
0
ACS Omega, Год журнала: 2025, Номер unknown
Опубликована: Май 29, 2025
Язык: Английский
Процитировано
0