Medicine,
Год журнала:
2025,
Номер
104(18), С. e42303 - e42303
Опубликована: Май 2, 2025
Background:
Nonalcoholic
fatty
liver
disease
(NAFLD)
is
a
chronic
characterized
by
intrahepatic
accumulation
and
closely
associated
with
metabolic
problems.
Some
studies
have
indicated
that
Chaihu-Shugan-San
(CSS)
may
positive
effect
on
NAFLD,
but
robust
evidence-based
research
to
substantiate
the
application
of
CSS
scarce.
A
meta-analysis
was
conducted
assess
clinical
efficacy
safety
in
treatment
for
NAFLD.
Methods:
The
literature
reporting
NAFLD
searched
from
inception
October
2023
7
Chinese
or
English
databases.
Studies
were
screened
incorporated
based
predefined
criteria.
Data
extracted
quality
assessed
independently
2
researchers
according
Cochrane
risk
bias
tools.
changes
outcomes
analyzed
using
mean
difference
(MD)
95%
confidence
intervals
(CIs)
random-
fixed-effects
model
examine
CSS.
RevMan5.4
software
used
perform
meta-analyses,
meta
package
R
4.0.0
publication
analysis.
Results:
total
17
involving
1576
participants
meta-analysis.
There
high
heterogeneity
among
all
continuous
outcomes.
Compared
common
treatments,
could
decrease
aspartate-aminotransferase
(MD
=
−12.02,
CI
[−15.97,
−8.07]),
alanine-aminotransferase
−10.89,
[−16.35,
−5.43]),
triglyceride
cholesterol
levels.
In
addition,
increase
high-density
lipoprotein
And,
lower
incidence
adverse
events
(RR
0.79,
[0.33,
1.91]).
Conclusion:
Current
evidence
shows
single
combined
use
effective
enzymes
blood
lipids.
Nevertheless,
it
challenging
reach
conclusive
determination
owing
significant
ambiguous
some
trials.
Therefore,
more
high-quality
required
implementation
Biomimetics,
Год журнала:
2025,
Номер
10(2), С. 73 - 73
Опубликована: Янв. 24, 2025
The
gut
microbiota
is
a
complex
and
dynamic
ecosystem
that
plays
fundamental
role
in
human
health
by
regulating
immunity,
metabolism,
the
gut–brain
axis.
Beyond
its
critical
physiological
functions,
it
has
emerged
as
rich
source
of
inspiration
for
biomimetic
innovations
healthcare
biotechnology.
This
review
explores
transformative
potential
microbiota-based
biomimetics,
focusing
on
key
biological
mechanisms
such
resilience,
self-regulation,
quorum
sensing.
These
have
inspired
development
innovative
applications,
including
personalized
probiotics,
synbiotics,
artificial
microbiomes,
bioinspired
biosensors,
bioremediation
systems.
Such
technologies
aim
to
emulate
optimize
intricate
functions
microbial
ecosystems,
addressing
challenges
environmental
sustainability.
integration
advanced
technologies,
intelligence,
bioengineering,
multi-omics
approaches,
further
accelerated
biomimetics.
tools
enable
precision
therapies
tailored
individual
profiles,
enhance
efficacy
diagnostic
systems,
facilitate
design
environmentally
sustainable
solutions,
waste-to-energy
systems
platforms.
Emerging
areas
innovation,
gut-on-chip
models
synthetic
biology,
offer
unprecedented
opportunities
studying
applying
principles
controlled
environments.
Despite
these
advancements,
remain.
replication
complexity
environments,
ethical
concerns
regarding
genetically
engineered
microorganisms,
equitable
access
are
hurdles
must
be
addressed.
underscores
importance
interdisciplinary
collaboration
public
awareness
overcoming
barriers
ensuring
responsible
solutions.
By
leveraging
biomimetics
represents
promising
frontier
approach
revolutionize
therapeutic
strategies,
redefine
tools,
address
global
challenges,
paving
way
more
personalized,
efficient,
future
medicine
Nutrition & Metabolism,
Год журнала:
2025,
Номер
22(1)
Опубликована: Янв. 6, 2025
Intermittent
fasting
(IF)
can
be
an
effective
dietary
therapy
for
weight
loss
and
improving
cardiometabolic
health.
However,
there
is
scant
evidence
regarding
the
role
of
IF
on
indicators
liver
function,
particularly
in
adults
with
metabolic
disorders.
Therefore,
we
performed
a
systematic
review
meta-analysis
to
investigate
effects
function
Three
primary
electronic
databases
including
PubMed,
Web
Science,
Scopus,
were
searched
from
inception
September
2024
identify
original
studies
that
used
interventions
or
without
control
groups
Inclusion
criteria
(1)
human
participants
diseases,
(2)
evaluated
IF,
(3)
group,
(4)
measured
fat,
steatosis,
fibrosis,
enzymes,
alanine
aminotransferase
(ALT)
aspartate
(AST)
as
outcomes.
Standardized
mean
differences
(SMD)
95%
confidence
intervals
calculated
using
random
models.
Heterogeneity
was
assessed
Cochran's
Q
statistic
I-squared
(I2).
Publication
bias
visual
inspection
funnel
plots
Egger's
tests.
The
risk
PEDro
scale
NIH
quality
assessment
tool.
A
total
21
involving
1,226
disorders
included
meta-analysis.
Overall,
effectively
decreased
fat
large
effect
size
[SMD:
-1.22
(95%
CI:
-1.63
-0.80),
p
=
0.001],
steatosis
medium
-0.73
-1.12
-0.35),
ALT
small
-0.44
-0.58
-0.30),
AST
-0.30
-0.49
-0.11),
but
not
fibrosis
-0.28
-0.59
0.02),
0.07].
Subgroup
analyses
showed
significantly,
independent
mode,
participant
age,
health
status,
intervention
duration.
significantly
those
obesity;
following
5:2
diets,
middle-aged
adults,
obesity,
regardless
status
seems
disorders,
many
function-related
benefits
occur
duration,
status.
Significant
heterogeneity,
numbers
inclusion
non-randomized
trials
single-group
pre-post
main
limitation
our
Further
randomized
clinical
are
needed
elucidate
Frontiers in Gastroenterology,
Год журнала:
2025,
Номер
3
Опубликована: Янв. 14, 2025
Non-alcoholic
fatty
liver
disease
(NAFLD)
has
a
rapidly
growing
incidence
worldwide,
affecting
approximately
one-third
of
world
population.
The
disturbance
gut
commensal
bacteria
impacting
host’s
homeostasis
is
referred
to
as
dysbiosis.
microbiome
contributes
the
pathogenesis
NAFLD
through
various
pathways.
Gut
microbiota
at
constant
interactions
with
intestinal
epithelial
barrier
and
affects
its
integrity.
Through
gut-liver
axis,
may
influence
immune
function.
release
lipopolysaccharides
(LPS)
from
intestines
portal
vein
which
are
transported
liver,
trigger
hepatic
inflammation,
steatosis
even
fibrosis.
Moreover,
induces
conversion
primary
bile
acids
(BAs)
secondary
BAs,
activates
receptors,
such
FXR
TGR5.
activation
decreases
fat
absorption
thus
reduces
lipid
accumulation,
while
TGR5
promotes
glucagon-like
peptide-1
(GLP-1)
in
blood.
Furthermore,
ethanol-producing
been
implicated
development.
Additionally,
there
reduction
levels
short-chain
acids,
butyrate,
propionate
acetate.
Many
bacterial
alterations
have
observed
NAFLD,
including
increased
Bacteroidetes
decreased
Firmicutes
.
probiotics
tried
prevention
management,
plethora
strains
Lactobacilli
,
Bifidobacteria
Streptococcus
some
them
promising
perspectives.
There
also
data
administration
prebiotics
(such
inulin
fructo-oligosaccharides)
symbiotics
(probiotics
plus
prebiotics).
Faecal
transplantation
(FMT)
yet
be
evaluated
for
efficacy
against
NAFLD.
Biomimetics,
Год журнала:
2025,
Номер
10(1), С. 56 - 56
Опубликована: Янв. 15, 2025
The
ability
to
control
and
manipulate
biological
fluids
within
microchannels
is
a
fundamental
challenge
in
diagnosis
pharmaceutical
analyses,
particularly
when
buffers
with
very
high
ionic
strength
are
used.
In
this
study,
we
investigate
the
numerical
experimental
study
of
fluidic
biochips
driven
by
ac
electrothermal
flow
for
controlling
manipulating
samples
inside
microchannel,
e.g.,
fluid-driven
manipulation
purposes
such
as
concentrating
mixing.
By
appropriately
switching
voltage
on
electrode
structures
inducing
AC
forces
channel,
network
pumping
capabilities
can
be
achieved,
enabling
fluid
velocity/direction
also
rotation.
using
finite
element
analysis,
coupled
physics
electrical,
thermal,
fields,
molecular
diffusion
transport
were
solved.
was
studied
mixing
applications,
optimal
model
extracted.
microfluidic
chip
fabricated
two
processes:
structure
development
silicon
mold
fabrication
cleanroom.
PDMS
prepared
microchannel
material
bonded
structure.
After
implementing
holder
excitation
circuit,
buffer
varying
strengths
(0.2,
0.4,
0.6
[S/m])
prepared,
mixed
fluorescent
particles,
loaded
into
chip.
Experimental
results
demonstrated
efficiency
proposed
showing
that
stronger
flows
generated
increasing
conductivity
voltage.
system
behavior
characterized
an
impedance
analyzer.
Frequency
response
analysis
revealed
solution
electrical
[S/m],
velocity
remained
almost
constant
frequency
range
100
kHz
10
MHz.
Overall,
showed
good
agreement
simulation
outcomes.
