Boosting the antibacterial potency of natural products through nanotechnologies
International Journal of Pharmaceutics,
Год журнала:
2025,
Номер
unknown, С. 125437 - 125437
Опубликована: Март 1, 2025
Язык: Английский
Comparative Metabolomics Analysis of Terpenoid and Flavonoid in Roots of Red Beet and Sugar Beet (Beta vulgaris L.)
Sugar Tech,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 24, 2025
Язык: Английский
Research Progress of Flavonoids in Spinal Cord Injury: Therapeutic Mechanisms and Drug Delivery Strategies
Phytotherapy Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 2, 2025
Spinal
cord
injury
(SCI)
is
a
serious
neurological
disease
with
an
extremely
high
disability
rate.
Most
patients
show
loss
of
motor
and
sensory
functions
below
the
level
injury.
Current
treatment
protocols
are
based
on
early
surgical
decompression
pharmacotherapy.
However,
efficacy
these
interventions
suboptimal.
Due
to
its
complex
pathophysiological
mechanisms
difficulty
central
nervous
system
(CNS)
regeneration,
exploring
effective
therapeutic
remains
daunting.
Flavonoids
secondary
metabolites
unique
plants
that
have
attracted
attention
in
recent
years
for
their
potential
now
commonly
used
inflammation,
tumors,
other
diseases.
For
SCI,
related
studies
still
exploring;
some
compounds,
such
as
quercetin,
fisetin,
hesperetin,
shown
good
anti-inflammatory
anti-apoptotic
properties,
which
help
restore
function
injured
spinal
cord.
flavonoids
exhibit
certain
disadvantages,
including
poor
solubility,
low
bioavailability,
inability
achieve
long-term
controlled
release.
Some
proposed
drug
delivery
strategies-including
nanoparticles,
hydrogels,
collagen
scaffolds-to
enhance
efficacy.
In
this
paper,
we
summarize
strategies
SCI
by
searching
relevant
literature
propose
future
research
directions
provide
new
ideas
multimodal
SCI.
Язык: Английский
Utilization of natural products in diverse pathogeneses of diseases associated with single or double DNA strand damage repair
Chinese Medicine,
Год журнала:
2025,
Номер
20(1)
Опубликована: Апрель 7, 2025
Abstract
The
appearance
of
DNA
damage
often
involves
the
participation
related
enzymes,
which
can
affect
onset
and
development
various
diseases.
Several
natural
active
compounds
have
been
found
to
efficiently
adjust
activity
crucial
enzymes
associated
with
single
or
double-strand
damage,
thus
demonstrating
their
promise
in
treating
This
paper
provides
an
in-depth
examination
summary
these
modulation
mechanisms,
leading
a
thorough
review
subject.
connection
between
disease
is
explored
through
analysis
structural
characteristics
compounds.
By
reviewing
how
different
scholarly
sources
describe
identical
structures
using
varied
terminology,
this
study
also
delves
into
effects
on
enzyme
regulation.
offers
potentially
be
used
therapeutically
influence
key
activities
expression
levels,
turn
process
repair
(DDR).
These
shown
not
only
reduce
occurrence
but
boost
efficiency
processes,
presenting
new
therapeutic
opportunities
for
conditions
such
as
cancer
other
pathologies.
Future
research
should
focus
clarifying
exact
mechanisms
maximize
clinical
utility
support
creation
novel
approaches
prevention
treatment.
Graphical
abstract
Язык: Английский
The G-quadruplex ligand CX-5461: an innovative candidate for disease treatment
Journal of Translational Medicine,
Год журнала:
2025,
Номер
23(1)
Опубликована: Апрель 18, 2025
The
ribosomal
DNA
(rDNA)
plays
a
vital
role
in
regulating
protein
synthesis
by
ribosome
biogenesis,
essential
for
maintaining
cellular
growth,
metabolism,
and
more.
Cancer
cells
show
high
dependence
on
biogenesis
exhibit
elevated
rDNA
transcriptional
activity.
CX-5461,
also
known
as
Pidnarulex,
is
First-in-Class
anticancer
drug
that
has
received
'Fast
Track
Designation'
approval
from
the
FDA.
Initially
reported
to
inhibit
Pol
I-driven
transcription,
CX-5461
was
recently
identified
G-quadruplex
structure
(G4)
stabilizer
currently
completed
or
undergoing
multiple
Phase
I
clinical
trials
patients
with
breast
ovarian
cancers
harboring
BRCA1/2,
PALB2,
other
repair
deficiencies.
Additionally,
preclinical
studies
have
confirmed
demonstrates
promising
therapeutic
effects
against
multifarious
non-cancer
diseases,
including
viral
infections,
autoimmune
diseases.
This
review
summarizes
mechanisms
of
its
inhibition
rDNA,
binding
G4,
toxicity
towards
topoisomerase,
along
research
status
across
various
Lastly,
this
highlights
targeted
therapy
strategy
based
nanomedicine
delivery,
particularly
delivery
utilizing
nucleic
acid
aptamer
AS1411,
which
contains
G4
motif
specifically
target
highly
expressed
nucleolin
surface
tumor
cell
membranes;
It
anticipates
coupling
peptide
acids
locked
achieve
dual
targeting,
thereby
realizing
individualized
G4-targeting
CX-5461.
aims
provide
general
overview
progress
recent
years
suggest
potential
strategies
disease
treatment
involving
RNA
synthesis,
topoisomerase.
Язык: Английский
Ethno pharmacological evidence and exploration of the phytochemical profile by GC-MS of bioactive compounds extracted from Sterculia setigera
South African Journal of Botany,
Год журнала:
2025,
Номер
181, С. 117 - 133
Опубликована: Апрель 19, 2025
Язык: Английский
Polyphenols: From Classification to Therapeutic Potential and Bioavailability
Foods,
Год журнала:
2024,
Номер
13(24), С. 4131 - 4131
Опубликована: Дек. 20, 2024
Though
ubiquitous
in
nature,
polyphenols
gained
scientific
prominence
only
after
the
pioneering
work
of
researchers
like
E.
Fischer
and
K.
Freudenberg,
who
demonstrated
their
potential
beyond
traditional
applications,
such
as
leather
industry.
Today,
these
bioactive
compounds
are
recognized
for
diverse
therapeutic
roles,
including
use
adjuvants
cancer
treatment,
prevention,
anti-inflammatory
antioxidant
properties.
Additionally,
have
benefits
managing
obesity,
cardiovascular
diseases,
neuromodulation.
Their
synthesis
is
influenced
by
environmental
genetic
factors,
with
concentrations
varying
based
on
intensity
variables,
well
stage
ripening.
This
review
provides
a
comprehensive
overview
polyphenols,
covering
classification,
chemical
structures,
bioavailability.
The
mechanisms
influencing
bioavailability,
bioaccessibility,
bioactivity
explored
detail,
alongside
an
introduction
to
effects
associated
metabolic
pathways.
Specific
examples,
bioavailability
coffee
various
types
onions,
analyzed.
Despite
promising
biological
activities,
significant
limitation
lies
inherently
low
oral
However,
systemic
circulation
by-products
formed
during
digestion
present
exciting
opportunities
further
research
application.
Язык: Английский
DNA as a Double-Coding Device for Information Conversion and Organization of a Self-Referential Unity
DNA,
Год журнала:
2024,
Номер
4(4), С. 473 - 493
Опубликована: Ноя. 19, 2024
Living
systems
are
capable
on
the
one
hand
of
eliciting
a
coordinated
response
to
changing
environments
(also
known
as
adaptation),
and
other
hand,
they
reproducing
themselves.
Notably,
adaptation
environmental
change
requires
monitoring
surroundings,
while
reproduction
oneself.
These
two
tasks
appear
separate
make
use
different
sources
information.
Yet,
both
process
well
that
inextricably
coupled
alterations
in
genomic
DNA
expression,
cell
behaves
an
indivisible
unity
which
apparently
independent
processes
mechanisms
integrated
coordinated.
We
argue
at
most
basic
level,
this
integration
is
enabled
by
unique
property
act
double
coding
device
harboring
logically
distinct
types
review
biological
complexities
infer
inter-conversion
these
information
represents
fundamental
self-referential
underlying
systemic
adaptive
responses.
Язык: Английский