From mechanisms to medicine: Ferroptosis as a Therapeutic target in liver disorders
Cell Communication and Signaling,
Год журнала:
2025,
Номер
23(1)
Опубликована: Март 7, 2025
In
recent
10
years,
ferroptosis
has
become
a
hot
research
direction
in
the
scientific
community
as
new
way
of
cell
death.
Iron
toxicity
accumulation
and
lipotoxicity
are
unique
features.
Several
studies
have
found
that
is
involved
regulation
hepatic
microenvironment
various
metabolisms,
thereby
mediating
progression
related
liver
diseases.
For
example,
NRF2
FSP1,
important
regulatory
proteins
ferroptosis,
development
tumors
failure.
this
manuscript,
we
present
mechanisms
concern
with
addition,
summarize
clinical
advances
targeted
therapy
for
We
expect
manuscript
can
provide
perspective
treatment
Язык: Английский
Hepatoprotective Effects of Citri reticulatae Pericarpium and Chaenomelese speciosa (Sweet) Nakai Extracts in Alcohol-Related Liver Injury: Modulation of Oxidative Stress, Lipid Metabolism, and Gut Microbiota
Antioxidants,
Год журнала:
2025,
Номер
14(3), С. 343 - 343
Опубликована: Март 14, 2025
Chronic
and
excessive
alcohol
consumption
induces
alcohol-related
liver
injury
(ALI),
characterized
by
oxidative
stress
(OS),
disrupted
lipid
metabolism,
gut
microbiota
dysbiosis.
Given
the
lack
of
effective
pharmacological
treatments,
flavonoid-rich
fruits
have
attracted
growing
attention
as
potential
intervention
strategies.
This
study
investigated
independent
combined
effects
extracts
from
Citri
reticulatae
pericarpium
(CRPE)
Chaenomeles
speciosa
(Sweet)
Nakai
(CSPE),
previously
shown
to
possess
hepatoprotective
properties,
in
a
mouse
model
ethanol-induced
chronic
ALI.
The
flavonoid
composition
CRPE
CSPE
was
using
LC-MS/MS,
their
mechanisms
action
were
further
elucidated
through
transcriptomic
analysis.
results
showed
that
CSPE,
whether
administered
individually
or
combination,
effectively
alleviated
alcohol-induced
hepatic
histological
damage
inflammatory
responses.
Furthermore,
both
significantly
reduced
OS
improved
metabolism.
Notably,
CRPE,
combination
regulated
microbiota,
increased
abundances
beneficial
bacteria
such
Lactobacillus
Bifidobacterium,
along
with
elevated
levels
short-chain
fatty
acids
(SCFAs).
These
findings
highlight
combinations
multiple
fruit
exhibit
significant
alleviating
ALI
modulating
providing
valuable
insights
for
development
functional
foods.
Язык: Английский
RNA Binding Motif protein 25 Is a Negative Prognostic Biomarkers and Promotes Cell Proliferation Regulated Via Alternative Splicing In Hepatocellular Carcinoma
Pathology - Research and Practice,
Год журнала:
2025,
Номер
unknown, С. 155941 - 155941
Опубликована: Март 1, 2025
Язык: Английский
Global research status and frontiers on ferroptosis in hepatocellular carcinoma: a comprehensive bibliometric and visualized analysis
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Май 2, 2025
Objective
The
purpose
of
this
study
was
to
analyze
the
research
hotspots
and
future
trends
in
field
ferroptosis
hepatocellular
carcinoma
past
10
years
by
using
bibliometrics
visualization
software,
provide
reference
for
directions
field.
Methods
Web
Science
database
searched
from
January
1,
2012,
October
30,
2024,
annual
publication
volume,
countries,
institutions,
journals,
authors,
references,
keywords,
other
information
were
analyzed
bibliometrics,
VOSviewer,
CiteSpace.
Results
A
total
645
English
articles
729
institutions
32
countries
included
study,
with
4545
authors
published
261
journals.
In
three
years,
518
published,
accounting
80.3%.
China
has
most
publications,
followed
United
States.
Frontiers
Oncology
had
highest
number
papers
(n=26),
while
Cell
citations
(n=1206).
current
mainly
focuses
on
two
aspects:
one
is
mechanism
explore
new
therapeutic
targets,
exploration
methods,
such
as
photodynamic
therapy
nanomaterials,
order
inhibit
proliferation
tumor
cells,
reduce
drug
resistance,
enhance
efficacy
regulating
ferroptosis,
which
may
become
a
development
trend.
Conclusion
recent
there
have
been
increasing
studies
association
between
carcinoma.
This
first
comprehensive
bibliometric
provides
reliable
promotes
its
further
development.
Язык: Английский