Journal of Ethnopharmacology, Год журнала: 2020, Номер 267, С. 113632 - 113632
Опубликована: Ноя. 27, 2020
Язык: Английский
Pharmacological Research, Год журнала: 2020, Номер 159, С. 104919 - 104919
Опубликована: Май 26, 2020
Язык: Английский
Процитировано
330
Biomedicines, Год журнала: 2021, Номер 9(10), С. 1353 - 1353
Опубликована: Сен. 29, 2021
Cancer is one of the leading causes death globally. The development drug resistance main contributor to cancer-related mortality. cells exploit multiple mechanisms reduce therapeutic effects anticancer drugs, thereby causing chemotherapy failure. Natural products are accessible, inexpensive, and less toxic sources chemotherapeutic agents. Additionally, they have action inhibit various targets involved in resistance. In this review, we summarized basic research clinical applications natural as possible inhibitors for cancer. molecular each product also explained. Diverse biomarkers were sensitive products. P-glycoprotein breast cancer protein can be targeted by a large number On other hand, kinase C topoisomerases most studied studies discussed review will provide solid ground scientists explore use combination therapies overcome targeting mechanisms.
Язык: Английский
Процитировано
129
Medicinal Research Reviews, Год журнала: 2023, Номер 43(3), С. 614 - 682
Опубликована: Янв. 19, 2023
Abstract Ferroptosis is an iron‐dependent cell death program that characterized by excessive lipid peroxidation. Triggering ferroptosis has been proposed as a promising strategy to fight cancer and overcome drug resistance in antitumor therapy. Understanding the molecular interactions structural features of ferroptosis‐inducing compounds might therefore open door efficient pharmacological strategies against aggressive, metastatic, therapy‐resistant cancer. We here summarize mechanisms requirements small molecules target central players ferroptosis. Focus placed on (i) glutathione peroxidase (GPX) 4, only GPX isoenzyme detoxifies complex membrane‐bound hydroperoxides, (ii) cystine/glutamate antiporter system X c − for regeneration, (iii) redox‐protective transcription factor nuclear erythroid 2‐related (NRF2), (iv) GPX4 repression combination with induced heme degradation via oxygenase‐1. deduce common ferroptotic activity highlight challenges development. Moreover, we critically discuss potential natural products lead structures provide comprehensive overview structurally diverse biogenic bioinspired trigger iron oxidation, inhibition thioredoxin/thioredoxin reductase or less defined modes action.
Язык: Английский
Процитировано
54
Experimental Hematology and Oncology, Год журнала: 2023, Номер 12(1)
Опубликована: Июль 27, 2023
Abstract Background Ferroptosis is a regulated cell death mode triggered by iron-dependent toxic membrane lipid peroxidation. As novel modality that morphologically and mechanistically different from other forms of death, such as apoptosis necrosis, ferroptosis has attracted extensive attention due to its association with various diseases. Evidence on potential therapeutic strategy accumulated the rapid growth research targeting for tumor suppression in recent years. Methods We summarize currently known characteristics major regulatory mechanisms present role cellular stress responses, including ER autophagy. Furthermore, we elucidate applications radiotherapy immunotherapy, which will be beneficial exploring new strategies clinical treatment. Result conclusion Based specific biomarkers precise patient-specific assessment, great translated into practical approaches cancer therapy, significantly contributing prevention, diagnosis, prognosis, treatment cancer.
Язык: Английский
Процитировано
45
Biomedicine & Pharmacotherapy, Год журнала: 2020, Номер 130, С. 110710 - 110710
Опубликована: Сен. 16, 2020
The development of chemotherapy drugs has promoted anticancer treatment, but the effect on tumours is not clear because treatment resistance; thus, it necessary to further understand mechanism cell death explore new therapeutic targets. As a type programmed death, ferroptosis increasingly being targeted in many cancers with clinical and experimental compounds. Ferroptosis stimulated inherently high levels ferrous ions by reaction abundant polyunsaturated fatty acids inhibition antioxidant enzymes, which can overcome resistance mainly through GPX4. In this review, we focus intrinsic cellular regulators against cancer resistance, such as GPX4, NRF2 thioredoxin system. We summarize application novel compounds circumvent resistance. also introduce nanoparticles for resistant cancers. conclusion, targeting represents considerable strategy treatment.
Язык: Английский
Процитировано
81
Biochemical and Biophysical Research Communications, Год журнала: 2019, Номер 523(1), С. 140 - 146
Опубликована: Дек. 16, 2019
Язык: Английский
Процитировано
80
Pharmacology & Therapeutics, Год журнала: 2021, Номер 232, С. 107992 - 107992
Опубликована: Окт. 1, 2021
Язык: Английский
Процитировано
80
Acta Pharmaceutica Sinica B, Год журнала: 2020, Номер 10(9), С. 1601 - 1618
Опубликована: Янв. 21, 2020
Necroptosis, a genetically programmed form of necrotic cell death, serves as an important pathway in human diseases. As critical cell-killing mechanism, necroptosis is associated with cancer progression, metastasis, and immunosurveillance. Targeting by small molecule modulators emerging effective approach therapy, which has the advantage to bypass apoptosis-resistance maintain antitumor immunity. Therefore, better understanding mechanism necessary develop novel strategies for therapy. This review will summarize recent progress mechanisms detecting methods necroptosis. In particular, relationship between therapy medicinal chemistry be focused on.
Язык: Английский
Процитировано
78
Cancers, Год журнала: 2021, Номер 13(2), С. 304 - 304
Опубликована: Янв. 15, 2021
Apoptosis has been considered the main mechanism induced by cancer chemotherapeutic drugs for a long time. This paradigm is currently evolving and changing, as increasing evidence pointed out that antitumor agents could trigger various non-canonical or non-apoptotic cell death types. A considerable number of derive from natural sources, both in their naturally occurring form synthetic derivatives. Therefore, it not surprising several compounds have explored ability to induce death. The aim this review highlight potential effects products ferroptosis, necroptosis, pyroptosis inducers. Natural proven be promising inducers, capable overcoming cells resistance apoptosis. However, discussed review, they often lack full characterization activity together with an in-depth investigation toxicological profile.
Язык: Английский
Процитировано
56
Pharmacological Research, Год журнала: 2021, Номер 168, С. 105580 - 105580
Опубликована: Март 27, 2021
Язык: Английский
Процитировано
56