Engeletin alleviates depressive‐like behaviours by modulating microglial polarization via the LCN2/CXCL10 signalling pathway

Journal of Cellular and Molecular Medicine, Год журнала: 2024, Номер 28(8)

Опубликована: Апрель 1, 2024

Microglial polarization and associated inflammatory activity are the key mediators of depression pathogenesis. The natural Smilax glabra rhizomilax derivative engeletin has been reported to exhibit robust anti-inflammatory activity, but no studies date have examined mechanisms through which it can treat depressive symptoms. We showed that treatment for 21 days with significantly alleviated depressive-like behaviours in chronic stress social defeat (CSDS) model mice. T1-weighted imaging (T1WI), T2-weighted (T2WI) revealed significant differences between groups, bilateral prefrontal cortex CSDS mice exhibited increases apparent diffusion coefficient T2 values relative normal control mice, a corresponding reduction fractional anisotropy, while reversed all these changes. resulted higher levels IL-1β, IL-6, TNF-a production, enhanced microglial activation, greater M1 concomitant decrease M2 mPFC, whereas effectively abrogated CSDS-related pathological Engeletin was further found suppress LCN2/C-X-C motif chemokine ligand 10 (CXCL10) signalling axis such adeno-associated virus-induced LCN2 overexpression ablated antidepressant effects its beneficial on M1/M2 microglia. In conclusion, alleviate CSDS-induced by regulating LCN2/CXCL10 pathway thereby altering These data suggest correlated microglia, highlighting potential avenue future design strategies specifically target

Язык: Английский

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Inflammatory pathophysiological mechanisms implicated in postpartum depression

Frontiers in Pharmacology, Год журнала: 2022, Номер 13

Опубликована: Ноя. 3, 2022

Postpartum Depression (PPD) is a serious psychiatric disorder of women within the first year after delivery. It grievously damages women’s physical and mental health. Inflammatory reaction theory well-established in depression, also has been reported associated with PPD. This review summarized inflammatory pathophysiological mechanisms implicated PPD, including decreased T cell activation, increased proinflammatory cytokines secretion, active kynurenine pathway, initiated NLRP3 inflammasome. Clinical preclinical research are both gathered. Potential therapeutical alternatives targeting PPD were introduced. In addition, this briefly discussed differences between depression. The inflammation limited seems just embarking, which indicates direction we can further study. As variety risky factors contribute to collectively, therapy for should be comprehensive, clinical heterogeneity taken into consideration. predictability, early screening interventions needed. aims help readers better understand pathological so as identify biomarkers potential therapeutic targets future.

Язык: Английский

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Insight into the mechanism of Xiao–Chai–Hu–Tang alleviates irinotecan-induced diarrhea based on regulating the gut microbiota and inhibiting Gut β-GUS

Phytomedicine, Год журнала: 2023, Номер 120, С. 155040 - 155040

Опубликована: Авг. 19, 2023

Язык: Английский

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Modulation of cellular metabolism and alleviation of bacterial dysbiosis by Aconiti Lateralis Radix Praeparata in non-small cell lung cancer treatment

Phytomedicine, Год журнала: 2023, Номер 126, С. 155099 - 155099

Опубликована: Сен. 18, 2023

Язык: Английский

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Homotherapy-for-heteropathy of Bupleurum Chinense DC.-Scutellaria baicalensis Georgi in treating depression and colorectal cancer: A network pharmacology and animal model approach

Journal of Ethnopharmacology, Год журнала: 2024, Номер 328, С. 118038 - 118038

Опубликована: Март 12, 2024

Bupleurum chinense DC.-Scutellaria baicalensis Georgi (BS) is a classic drug pair that has good clinical effects on depression and many tumors. However, the concurrent targeting mechanism of how aforementioned valid in two distinct diseases, not been clarified yet. The components BS were detected by LC-MS, combined with network pharmacology to explore active ingredients common its multi-pathway regulation treating CRC, validate dual using CUMS mice model orthotopic transplantation tumor CRC. Twenty-nine screened, 84 gene targets obteined, top 5 key including STAT3, PIK3R1, PIK3CA, AKT1, IL-6 identified PPI network. GO KEGG analyses revealed PI3K/AKT JAK/STAT signaling pathways might play crucial role regulating significantly modulated CUMS-induced depressive-like behavior, attenuated neuronal damage, reduced serum EPI NE levels mice. improved pathological histological changes solid tumors liver tissues inhibited metastases CT26-bearing decreased proteins' expression IL-6, p-JAK2, p-STAT3, p-PI3K, p-AKT1 hippocampal tumors, regulated IL-2, IL-10 models can exert antidepressant anti-CRC inhibiting IL-6/JAK2/STAT3 pathway proteins release inflammatory cytokines.

Язык: Английский

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