Frontiers in Cellular Neuroscience,
Год журнала:
2025,
Номер
19
Опубликована: Апрель 23, 2025
Major
depressive
disorder
(MDD)
is
one
of
the
most
common
mental
health
conditions,
characterized
by
pervasive
and
persistent
low
mood,
self-esteem,
a
loss
interest
or
pleasure
in
activities
that
are
typically
enjoyable.
Despite
decades
research
into
etiology
pathophysiological
mechanisms
depression,
therapeutic
outcomes
for
many
individuals
remain
less
than
expected.
A
promising
new
area
focuses
on
stress-induced
neuroinflammatory
processes,
such
as
excessive
activation
crosstalk
microglia
astrocytes
central
nervous
system
under
stress,
well
elevated
levels
pro-inflammatory
cytokines,
which
closely
linked
to
onset
progression
depression.
This
review
summarizes
through
neuroinflammation
induces
promotes
development
also
highlights
effective
roles
small
molecules
with
anti-inflammatory
activity
treatment
MDD.
Understanding
specific
further
impacts
using
technologies
single-cell
RNA
sequencing
elucidate
subtypes
interactions
great
importance
developing
more
strategies
Antioxidants,
Год журнала:
2023,
Номер
12(4), С. 817 - 817
Опубликована: Март 27, 2023
There
is
increasing
interest
in
the
involvement
of
antioxidative
systems
protecting
from
depression.
Among
these,
Nrf2
occupies
a
central
place.
We
aimed
to
review
role
For
this
reason,
we
conducted
PubMed
search
using
as
strategy
(psychiatr*[ti]
OR
schizo*[ti]
psychot*[ti]
psychos*[ti]
depress*[ti]
MDD[ti]
BD[ti]
bipolar[ti]
Anxiety[ti]
antidepress*[ti]
panic[ti]
obsess*[ti]
compulsio*[ti]
“mood
disord*”[ti]
phobi*[ti]
agoraphob*[ti]
anorex*[ti]
anorect*[ti]
bulimi*[ti]
“eating
disorder*”[ti]
neurodevelopm*[ti]
retardation[ti]
autism[ti]
autistic[ti]
ASM[ti]
adhd[ti]
“attention-deficit”[ti])
AND
nrf2,
which
on
9th
March
produced
208
results
89
were
eligible
for
our
purposes.
Eligible
articles
studies
reporting
data
manipulations
or
content
by
any
treatment
human
patients
animals
with
animal
model
Most
mice
only
(N
=
58),
20
rats
only,
and
three
both
mice.
two
cell
lines
(in
vitro)
one
each
nematodes
fish.
Only
four
humans,
was
post
mortem.
male
animals;
however,
carried
out
men
women.
The
indicate
that
lower
depression
antidepressant
methods
(drugs
other
methods)
increase
it.
Antioxidant
plasticity-promoting
molecules,
such
those
Nrf2–HO-1,
BDNF–TrkB,
cyclic
AMP–CREB
pathways,
could
protect
depression,
while
glycogen
synthase
kinase-3β
nuclear
factor
κB
oppose
these
actions,
thus
depressive-like
behaviours.
Since
also
endowed
tumorigenic
atherogenic
potential,
balance
between
benefits
harms
must
be
taken
into
account
designing
novel
drugs
aiming
at
intracellular
Nrf2.
CNS Neuroscience & Therapeutics,
Год журнала:
2023,
Номер
30(3)
Опубликована: Авг. 31, 2023
Abstract
Aim
We
investigated
the
effects
and
target
of
gastrodin
(GAS)
for
treating
depression
through
network
pharmacology
combined
with
experimentation.
Methods
The
therapeutic
signal
GAS
were
analyzed
by
pharmacology.
Depression
in
mice
was
mimicked
a
chronic
unpredictable
mouse
stress
(CUMS)
model.
Through
open
field,
elevated
plus
maze,
forced
swimming,
tail
suspension
tests,
on
CUMS
behaviors
examined,
levels
neurotransmitters
detected.
histopathological
changes
assayed
H&E
IHC
staining,
protein
expressions
detected
Western
blotting.
Small
molecule‐protein
docking
molecular
dynamics
experiments
conducted
to
simulate
binding
mode
between
Caspase‐3.
Results
Network
pharmacological
analysis
revealed
that
Caspase‐3
action
GAS.
could
improve
depression‐like
mice,
elevate
their
neurotransmitter
levels,
ameliorate
nerve
cell
injury,
inhibit
expression.
After
knocking
out
Caspase‐3,
inhibited.
Molecular
simulation
small
found
bound
at
SER25,
inhibiting
maturation
activation
Conclusion
find
can
act
as
inhibitor,
which
improves
injury
Caspase‐3‐mediated
apoptosis.
Behavioural Brain Research,
Год журнала:
2024,
Номер
465, С. 114968 - 114968
Опубликована: Март 22, 2024
Depression
is
a
psychiatric
disorder
and
the
treatment
of
depression
an
urgent
problem
that
need
to
be
solved.
Gastrodin
(GAS)
Traditional
Chinese
Medicine
from
orchid
used
for
neurological
diseases,
including
depressive
disorders.
To
assess
effect
GAS
on
gut
microbiota
mice,
we
established
chronic
unpredictable
mild
stress
(CUMS)-induced
mouse
model,
was
administered
one
group
mice.
Animal
behavior
experiments
were
detect
depressive-like
behaviors,
16
S
rRNA
gene
analysis
applied
each
group.
All
raw
sequences
deposited
in
NCBI
Sequence
Read
Archive
under
accession
number
SRP491061.
significantly
improved
behaviors
as
well
diversity
abundance
microbiota.
The
CUMS-GAS
different
degrees
compared
with
CUMS
linear
discriminant
(LDA)
showed
makeup
mice
changed
dramatically
group,
Bacteroides
(LDA
=
3.94,
P
<
0.05)
enriched
at
genus
level.
In
comparison
had
greater
concentration
numbers
Lactobacillus,
Corynebacterium,
Staphylococcus,
Bacteroides,
Psychrobacter,
Alistipes.
Our
results
suggested
impacted
microbial
composition
gut.
research
indicated
dysbiosis
may
affected
by
treatment,
which
CUMS-induced
model
depression.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(17), С. 9540 - 9540
Опубликована: Сен. 2, 2024
Blume
is
a
traditional
medicinal
and
food
homology
substance
that
has
been
used
for
thousands
of
years,
mainly
distributed
in
China
other
Asian
countries,
always
distinguished
as
superior
class
herbs.
Gastrodin
the
main
active
ingredient
Inflammation-induced
oligodendrocyte
death
and
CNS
demyelination
are
key
features
of
multiple
sclerosis
(MS).
Inflammation-triggered
endoplasmic
reticulum
(ER)
stress
oxidative
promote
tissue
damage
in
MS
its
preclinical
animal
model,
experimental
autoimmune
encephalitis
(EAE).
Compound
AA147
is
a
potent
activator
the
ATF6
signaling
arm
unfolded
protein
response
(UPR)
that
can
also
induce
antioxidant
through
activation
NRF2
pathway
neuronal
cells.
Previous
work
showed
protects
tissues
against
ischemia/reperfusion
and/or
activation;
however,
therapeutic
potential
neuroinflammatory
disorders
remains
unexplored.
Here,
we
demonstrate
ameliorated
clinical
symptoms
EAE
reduced
ER
stress,
loss,
demyelination.
Additionally,
suppressed
T
cells
without
altering
peripheral
immune
response.
Importantly,
significantly
increased
expressions
Grp78,
an
target
gene,
oligodendrocytes,
while
enhancing
levels
Grp78
as
well
Ho-1,
microglia.
In
cultured
promoted
nuclear
translocation
ATF6,
but
not
NRF2.
Intriguingly,
altered
microglia
profile,
possibly
by
triggering
pathway.
was
therapeutically
beneficial
during
acute
stage
mice
lacking
indicating
protection
primarily
involves
these
Overall,
our
results
suggest
opportunity
for
promoting
survival
regulating
status
distinct
mechanisms.
