Drug Design Development and Therapy,
Год журнала:
2024,
Номер
Volume 18, С. 4927 - 4942
Опубликована: Ноя. 1, 2024
Abstract:
Heart
failure
(HF)
is
a
disease
with
high
morbidity
and
mortality
rates
worldwide
significantly
affects
human
health.
Currently,
the
treatment
options
for
HF
are
limited,
there
an
urgent
need
to
discover
new
therapeutic
targets
strategies.
Macrophages
innate
immune
cells
involved
in
development
of
HF.
They
play
crucial
role
maintaining
cardiac
homeostasis
regulating
stress.
Recently,
macrophages
have
received
increasing
attention
as
potential
treating
With
improvement
technological
means,
study
has
made
great
progress.
This
article
discusses
biological
functions
macrophage
phagocytosis,
response,
tissue
repair.
The
polarization,
pyroptosis,
autophagy,
apoptosis
macrophages,
deeply
pathogenesis
Modulation
phenotypic
changes
can
improve
immune-inflammation,
myocardial
fibrosis,
energy
metabolism,
apoptosis,
angiogenesis
Keywords:
heart
failure,
macrophage,
autophagy
International Journal of Biological Sciences,
Год журнала:
2024,
Номер
20(11), С. 4258 - 4276
Опубликована: Янв. 1, 2024
Oxidative
stress
is
a
major
pathogenic
factor
in
many
intestinal
diseases,
such
as
inflammatory
bowel
disease
(IBD)
and
colorectal
cancer
(CRC).
The
Nrf2
signaling
pathway
mitophagy
can
reduce
reactive
oxygen
species
(ROS)
alleviate
oxidative
stress,
but
their
relationship
unclear.
Hydroxytyrosol
(HT),
polyphenolic
compound
abundant
olive
oil,
has
strong
antioxidant
activity
may
help
treat
these
diseases.
We
used
pigs
model
to
investigate
HT's
effect
on
damage
its
mechanisms.
Diquat
(DQ)
induced
impaired
barrier
function,
which
HT
mitigated.
Mechanistic
studies
IPEC-J2
cells
showed
that
protected
against
by
activating
the
PI3K/Akt-Nrf2
promoting
mitophagy.
Our
study
highlighted
synergistic
between
mediating
effects.
Inhibition
confirmed
disrupting
either
compromised
protective
Maintaining
redox
balance
through
important
for
eliminating
excess
ROS.
increases
enzymes
clear
existing
ROS,
while
removes
damaged
mitochondria
reduces
ROS
generation.
This
demonstrates
pathways
collaboratively
modulate
effects
of
HT,
with
neither
being
dispensable.
Targeting
could
be
promising
strategy
treating
stress-related
potential
treatment.
Frontiers in Physiology,
Год журнала:
2024,
Номер
15
Опубликована: Янв. 29, 2024
Mitochondria
are
energy
factories
that
sustain
life
activities
in
the
body,
and
their
dysfunction
can
cause
various
metabolic
diseases
threaten
human
health.
Mitophagy,
an
essential
intracellular
mitochondrial
quality
control
mechanism,
maintain
cellular
homeostasis
by
removing
damaged
mitochondria
participating
developing
diseases.
Research
has
confirmed
exercise
regulate
mitophagy
levels,
thereby
exerting
protective
effects
This
article
reviews
role
of
diseases,
on
mitophagy,
potential
mechanisms
exercise-regulated
intervention
providing
new
insights
for
future
basic
clinical
research
interventions
to
prevent
treat
Phytomedicine,
Год журнала:
2024,
Номер
132, С. 155827 - 155827
Опубликована: Июнь 14, 2024
Atherosclerosis
(AS)
is
the
main
pathological
basis
for
development
of
cardiovascular
diseases.
Vascular
inflammation
an
important
factor
in
formation
AS,
and
macrophage
pyroptosis
plays
a
key
role
AS
due
to
its
unique
inflammatory
response.
Guizhitongluo
Tablet
(GZTLT)
has
shown
clinically
effective
treating
patients
with
but
mechanism
elusive.
Phytotherapy Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 6, 2025
ABSTRACT
Mitophagy
is
a
process
by
which
cells
selectively
eliminate
damaged
or
dysfunctional
mitochondria
through
the
autophagy–lysosome
pathway,
thereby
maintaining
mitochondrial
quality
and
cellular
homeostasis.
This
closely
linked
to
onset
progression
of
various
heart
diseases.
Modern
pharmacological
research
has
demonstrated
that
phytochemicals
can
regulate
homeostasis
in
cardiomyocytes
multiple
mechanisms,
influencing
mitophagy
protecting
cardiomyocytes,
turn
exerts
anti‐cardiovascular
effects.
However,
underlying
mechanisms
these
effects
are
not
yet
fully
understood.
study
summarizes
molecular
diseases,
aiming
provide
reference
for
treatment
targeting
against
The
results
indicated
(such
as
Berberine,
Ginsenoside
Rg1,
Quercetin,
Resveratrol,
Baicalein,
so
on)
exert
preventive
therapeutic
on
diseases
cardiac
toxicity
damage,
myocardial
ischemia/reperfusion
injury,
failure,
aging,
hypertrophy,
cardiomyopathy,
on.)
via
regulating
PINK1/Parkin
FUNDC1‐dependent
pathway.
These
compounds
mainly
their
homeostasis,
dynamics,
oxidative
stress,
apoptosis,
energy
metabolism.
provides
have
effect
mitophagy.
further
in‐depth
mechanistic
clinical
needed
future.
Frontiers in Cardiovascular Medicine,
Год журнала:
2025,
Номер
12
Опубликована: Май 26, 2025
Cardiovascular
diseases
(CVDs)
pose
a
serious
threat
to
human
health
and
represent
one
of
the
leading
causes
death
worldwide.
Cellular
autophagy,
an
essential
intracellular
self-degradation
homeostasis
maintenance
mechanism,
plays
pivotal
role
in
pathogenesis
cardiovascular
diseases.
Traditional
Chinese
Medicine
(TCM),
with
its
unique
theoretical
framework
therapeutic
principles,
has
demonstrated
remarkable
efficacy
CVDs
management,
garnering
increasing
scientific
attention.
In
recent
years,
growing
research
attention
focused
on
TCM's
autophagy
regulation
for
treatment.
However,
most
studies
remain
limited
cellular
animal
models,
insufficient
clinical
data
unclear
specific
metabolic
pathways
targets.
Therefore,
it
is
imperative
(
1
)
investigate
mechanisms
depth
2
),
explore
methods
balance,
3
clarify
drug
interactions
establish
foundation
applications.
This
article
comprehensively
summarizes
relevant
findings,
provides
in-depth
discussion
treatment,
reviews
current
status,
outlines
future
development
trends,
aiming
offer
valuable
foundations
strategies
management.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(7), С. 3252 - 3252
Опубликована: Апрель 1, 2025
Atherosclerosis,
a
chronic
inflammatory
disease
characterized
by
lipid
accumulation
and
immune
cell
infiltration,
is
linked
to
plaque
formation
cardiovascular
events.
While
traditionally
associated
with
metabolism
endothelial
dysfunction,
recent
research
highlights
the
roles
of
autophagy
clonal
hematopoiesis
(CH)
in
its
pathogenesis.
Autophagy,
cellular
process
crucial
for
degrading
damaged
components,
regulates
macrophage
homeostasis
inflammation,
both
which
are
pivotal
atherosclerosis.
In
macrophages,
influences
metabolism,
cytokine
regulation,
oxidative
stress,
helping
prevent
instability.
Defective
exacerbates
impairs
cholesterol
efflux,
accelerates
progression.
Additionally,
autophagic
processes
cells
smooth
muscle
further
contribute
atherosclerotic
pathology.
Recent
studies
also
emphasize
interplay
between
CH,
wherein
somatic
mutations
genes
like
TET2,
JAK2,
DNMT3A
drive
expansion
enhance
responses
plaques.
These
modify
function,
intensifying
environment
accelerating
Chaperone-mediated
(CMA),
selective
form
autophagy,
plays
critical
role
regulating
inflammation
pro-inflammatory
cytokines
oxidized
low-density
lipoprotein
(ox-LDL).
Impaired
CMA
activity
leads
these
substrates,
activating
NLRP3
inflammasome
worsening
inflammation.
Preclinical
suggest
that
pharmacologically
may
mitigate
atherosclerosis
animal
models,
reduced
instability
increases
This
review
importance
regulation
focusing
on
formation,
contributions
CH.
Building
upon
current
advances,
we
propose
hypothesis
programmed
death,
intrinsic
axis
modulates
fundamental
functions
playing
complex
development
Understanding
mechanisms
offers
potential
therapeutic
strategies
targeting
reduce
burden
disease.
