Chemical diversity, traditional uses, and bioactivities of Rosa roxburghii Tratt: A comprehensive review

Pharmacology & Therapeutics, Год журнала: 2024, Номер 259, С. 108657 - 108657

Опубликована: Май 10, 2024

Язык: Английский

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Modification of a natural diterpene and its antitumor mechanism: Promoting apoptosis, suppressing migration, and inhibiting angiogenesis

Arabian Journal of Chemistry, Год журнала: 2024, Номер 17(3), С. 105603 - 105603

Опубликована: Янв. 4, 2024

The synthesis or derivation of a series structural analogues based on natural products is common strategy for discovering antitumor drugs. As unique diterpene derived from Trigonostemon howii, 3,4-seco-sonderianol (1) exhibited moderate cytotoxic effects. To improve the activity, new derivative (1b) with mitochondrial targeting function was synthesized by coupling triphenylphosphine to compound 1. Compared parent molecule, activity 1b increased greatly. A mechanistic experiments revealed that induced cancer cell apoptosis and inhibited migration mitochondria regulating STAT3 FAK signaling pathways. Meanwhile, found inhibit angiogenesis in transgenic zebrafish model. It worth noting also demonstrated excellent effects tumor xenotransplantation models. All evidence supports has potential be candidate an drug.

Язык: Английский

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Anti-Inflammatory and α-Glucosidase Inhibitory Triterpenoid with Diverse Carbon Skeletons from the Fruits of Rosa roxburghii

Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер 72(20), С. 11503 - 11514

Опубликована: Апрель 18, 2024

The fruits of Rosa roxburghii Tratt. are edible nutritional food with high medicinal value and have been traditionally used as Chinese folk medicine for a long time. In this study, 26 triterpenoids including four new pentacyclic triterpenoids, roxbuterpenes A–D (1, 4, 5, 24), along 22 known analogues (2, 3, 6–23, 25, 26), were isolated from the R. roxburghii. Their chemical structures determined on basis extensive spectroscopic analyses (including IR, HRESIMS NMR spectroscopy). absolute configuration roxbuterpene A (1) was by an X-ray crystallographic analysis. This is first report crystal structure 5/6/6/6/6-fused system triterpenoid. Notably, B (1 4) possessed A-ring contracted triterpenoid nortriterpenoid skeletons rare system, respectively. Compounds 1–7, 11, 13–15, 18–20, 24, 25 exhibited moderate or potent inhibitory activities against α-glucosidase. 2, 6, 14 showed strong α-glucosidase IC50 values 8.4 ± 1.6, 7.3 2.2, 13.6 1.4, 0.9 0.4, 12.5 2.4 μM, respectively (positive control acarbose, 10.1 0.8 μM). 13, 14, 16 moderately inhibited release NO (nitric oxide) ranging 25.1 2.0 to 51.4 3.1 μM. Furthermore, expressions TNF-α (tumor necrosis factor-α) IL-6 (interleukin-6) detected ELISA (enzyme-linked immunosorbent assay), compounds effects in dose-dependent manner 50

Язык: Английский

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UPLC-ESI-MS/MS-Based Analysis of Various Edible Rosa Fruits Concerning Secondary Metabolites and Evaluation of Their Antioxidant Activities

Foods, Год журнала: 2024, Номер 13(5), С. 796 - 796

Опубликована: Март 4, 2024

The genus Rosa is globally popular with well-established applications since it has a high edible and medicinal value. However, relatively limited research been conducted on the composition quality of wild fruits. present study aimed to compare properties chemical components five fruits, roxburghii, sterilis, laevigata, davurica, sericea. UPLC-ESI-MS/MS approach identified key metabolites among fruits as flavonoids, phenolic acids, organic acids. main differential are flavonoids (22.29–45.13%), acids (17–22.27%), terpenoids (7.7–24%), respectively. In total, 125 compounds served potential markers for species. Differential metabolic pathways were analyzed using KEGG approach. laevigata showed highest total polysaccharide (TPS) content 64.48 g/100 g. All extracts effectively decreased levels malondialdehyde while increasing activities superoxide dismutase glutathione peroxidase in H2O2-induced HaCaT cell model, demonstrating antioxidant development. Our findings suggest that studied exhibit biological activity value worth further exploration.

Язык: Английский

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Anti-osteosarcoma activity of Corynoline via Src/JNK signaling-mediated cell cycle arrest and mitochondrial apoptosis

International Immunopharmacology, Год журнала: 2025, Номер 148, С. 114126 - 114126

Опубликована: Янв. 24, 2025

Язык: Английский

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Chloride intracellular channel 6 inhibits hepatocellular carcinoma progression by modulating immune cell balance and promoting tumor cell apoptosis

CytoJournal, Год журнала: 2025, Номер 22, С. 20 - 20

Опубликована: Фев. 14, 2025

Objective Chloride intracellular channel 6 (CLIC6) is essential for the development of cancer, and it widely studied treatment various cancers. This study aimed to explore potential mechanisms CLIC6 in hepatocellular carcinoma (HCC). Material Methods Initially, a subcutaneous xenograft model HCC was established. The groups were treated with varying levels recombinant protein. After 21 days, tumor liver tissues harvested. Tumor size weight measured, hematoxylin-eosin staining used assess histopathological changes tissues. Terminal deoxynucleotidyl transferase-mediated 2’-deoxyuridine 5’-triphosphate nick-end labeling employed evaluate apoptosis tissue cells. Quantitative real-time polymerase chain reaction Western blot utilized analyze cytokine messenger ribonucleic acid ( mRNA) or tissues, immunohistochemistry conducted expression. Results significantly inhibits proliferation enhances markedly reduces mRNA interleukin (IL)-6, IL-1β, interferon-γ, necrosis factor-α, IL-17A when increasing transforming growth factor-β IL-4 levels. potentially modulates Th cell balance by regulating forkhead box protein P3, GATA-binding 3, T-box expressed T cell, retinoic receptor-related orphan receptor γt (ROR-γt) expression, thereby restraining progression mice. Moreover, mitigates hepatic oxidative damage via Janus tyrosine kinase 1/signal transducer activator transcription pathway, attenuates c-Jun N-terminal (JNK) phosphorylation, apoptosis-related proteins, effectively hindering development. Conclusion demonstrates potent antitumor effects through inhibition proliferation, promotion apoptosis, modulation levels, regulation immune balance, attenuation stress pathways.

Язык: Английский

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2-Dodecyl-6-Methoxycyclohexa-2,5-Diene-1,4-Dione from Averrhoa carambola L. roots: Suppressing hepatocellular carcinoma progression through ROS accumulation and p53 pathway-mediated apoptosis

Toxicology and Applied Pharmacology, Год журнала: 2025, Номер 498, С. 117296 - 117296

Опубликована: Март 13, 2025

Язык: Английский

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The Phytochemical Characterization of a Cili (Rosa roxburghii) Fruit Low-Temperature Extract with Hepatoprotective Effects

Foods, Год журнала: 2025, Номер 14(8), С. 1301 - 1301

Опубликована: Апрель 9, 2025

Cili (Rosa roxburghii Tratt) fruit is a nutrient-rich edible plant known for its antioxidant and hepatoprotective properties. However, conventional extraction methods often lead to the degradation of bioactive compounds. In this study, we developed low-temperature homogenate-assisted high-pressure disruption (HHPD) method obtain phytochemically enriched cili extract (HHPD-CFE). The chemical characterization HHPD-CFE showed that it contained higher levels polyphenols, polysaccharides, superoxide dismutase (SOD) than those in squeeze extraction. effects were evaluated oxidative stress-induced liver injury hepatic fibrosis models. mitigated damage by reducing malondialdehyde while enhancing SOD glutathione activity. Additionally, inhibited activation stellate cells (HSC-T6) reduced collagen deposition, suggesting protective role against fibrosis. These findings support promising botanical with compounds liver-protective This study supports potential application optimized techniques preserve thermosensitive improve efficacy functional foods health.

Язык: Английский

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Prickly pear (Rosa roxburghii Tratt.) extract alleviates ethanol-induced oxidative stress in vivo and in vitro via Fanconi Anemia pathway

Journal of Functional Foods, Год журнала: 2025, Номер 129, С. 106860 - 106860

Опубликована: Апрель 29, 2025

Язык: Английский

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Unraveling the Genetic Diversity and Phylogeography of the “King of Vitamin C” Fruit (Rosa roxburghii Trattinnick) in Chinese Southwest

Ecology and Evolution, Год журнала: 2025, Номер 15(5)

Опубликована: Май 1, 2025

ABSTRACT The southwestern region of China is one the last repositories biodiversity. Exploring genetic diversity and phylogeographical structure representative species in this area can not only provide insights into their evolutionary history but also help us specify protection plans. We conducted extensive sampling combined ISSR, cpDNA ( psb A‐ trn H, atp F‐ L‐ F, acc D‐ psa I, G‐ S), single‐copy nuclear gene ncpGS GAPDH ) data with MaxEnt model to investigate diversity, phylogeographic pattern potential distribution Rosa roxburghii Trattinnick, “King Vitamin C” fruit, region. study revealed high within R. populations, Guizhou Province identified as center origin. At least two glacial refugia were presented during Quaternary ice age. research emphasizes impact climate change geographic isolation on differentiation. This contributes understanding biodiversity offers a new perspective conservation wild other plant resources.

Язык: Английский

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