International Journal of Drug Delivery Technology,
Год журнала:
2023,
Номер
13(04), С. 1563 - 1567
Опубликована: Дек. 25, 2023
Cancer
is
a
heterogeneous
disease
and
ranks
among
the
most
pressing
health
concerns
faced
by
humans
requires
proactive
treatment
approach.
Plants
are
rich
source
of
compounds
offer
promising
avenue
for
cancer
research.
Chemotherapy
has
so
far
been
effective,
but
it
comes
with
some
very
unpleasant
side
effects.
Nerium
oleander,
an
evergreen
plant
cultivated
throughout
world,
many
metabolites,
including
cardiac
glycosides,
phenols,
saponins
terpenoids.
The
its
derivatives
have
essential
component
traditional
medicine
treating
several
ailments
from
beginning
time,
notably
cancer,
diabetes
mellitus,
asthma,
disease.
However,
scientific
community
not
gone
much
further
into
information.
This
review
aims
to
understand
therapeutic
applications
N.
focusing
on
cancer.
leaf
extract,
anvirzel
PBI-05204
entered
clinical
trials
other
derivates
like
oleandrin
breast
in
still
under
in-vitro
in-vivo
studies.
In
order
combat
operates
cancer-related
signaling
pathways,
Akt
mTOR
downstream
pathway.
Cell Biochemistry and Function,
Год журнала:
2024,
Номер
42(1)
Опубликована: Янв. 1, 2024
Abstract
Curcumin
is
a
natural
compound
derived
from
turmeric
and
can
target
malignant
tumor
molecules
involved
in
cancer
propagation.
It
has
potent
antioxidant
activity,
but
its
effectiveness
limited
due
to
poor
absorption
rapid
elimination
the
body.
Various
curcumin
derivatives
have
also
shown
anticancer
potential
in‐vitro
in‐vivo
models.
multiple
signaling
pathways
development/progression
or
induce
cell
death
through
apoptosis.
In
addition,
could
enhance
of
conventional
chemotherapy,
radiation
therapy
reduce
their
associated
side
effects.
Lately,
nanoparticle‐based
delivery
systems
are
being
developed/explored
overcome
challenges
with
curcumin's
delivery,
increasing
overall
efficacy.
The
use
an
imaging
system
track
these
formulations
give
beneficial
information
about
bioavailability
distribution
nano‐curcumin
complex.
conclusion,
holds
significant
promise
fight
against
cancer,
especially
nanoform,
provide
precise
cells
without
affecting
normal
healthy
cells.
Nutraceuticals,
Год журнала:
2024,
Номер
4(4), С. 562 - 595
Опубликована: Окт. 11, 2024
The
major
constituent
of
turmeric,
curcumin,
is
a
bioactive
phenolic
compound
that
has
been
studied
for
its
potential
health
benefits
and
therapeutic
properties.
Within
this
article,
the
anti-inflammatory,
antioxidant
antithrombotic
properties
mechanisms
action
curcumin
are
thoroughly
reviewed
main
focus
shifted
to
associated
health-promoting
effects
against
inflammation-related
chronic
disorders.
An
overview
cardio-protective,
anti-tumor,
anti-diabetic,
anti-obesity,
anti-microbial
neuro–protective
reviewed,
while
relative
outcomes
obtained
from
clinical
trials
also
presented.
Emphasis
given
wound-healing
as
presented
by
several
studies
trials,
which
further
promote
application
ingredient
in
functional
products,
including
foods,
nutraceuticals,
cosmetics
drugs.
Limitations
future
perspectives
such
uses
bio-functional
discussed.
Traditional
medicine
systems
worldwide
utilize
natural
products
(NPs),
including
plant-derived
compounds,
minerals,
and
organisms,
harnessing
their
healing
potential.
NPs
offer
a
rich
source
of
potential
drug
candidates,
driving
innovation
in
discovery.
Recent
breakthroughs
have
reignited
interest
the
therapeutic
benefits
compounds.
Clinical
applications
NP-based
immunotherapies,
such
as
curcumin
resveratrol
cancer
treatment,
highlight
diverse
pharmacological
properties.
However,
despite
these
advancements,
challenges
persist
clinical
implementation
NPs.
Issues
standardization,
regulatory
approval,
supply
sustainability
remain
significant
hurdles.
Overcoming
limitations
requires
concerted
effort
to
address
complexities
NP
development.
Nevertheless,
ongoing
research
efforts
interdisciplinary
collaboration
hold
promise
for
advancing
therapeutics,
paving
way
development
innovative
treatments
various
diseases.
In
world
precision
medicine,
new
chapter
unfolds
join
journey.
The
exploration
sources
bioactive
compounds
has
revealed
promising
prospects
therapeutics
medicine.
This
article
explores
within
context
It
examines
intricate
pathways
through
which
derived
from
nature
tailored
prospects,
emphasizing
role
interventions.
Exploring
synergy
between
at
molecular
level,
this
delineates
exciting
prospect
customized
treatments,
signifying
transformative
impact
on
modern
medical
care.
review
further
highlights
tailoring
based
individual
genetic
makeup
disease
characteristics.
Additionally,
it
discusses
addressing
issues
sourcing,
scalability,
considerations
realize
full
Metabolites,
Год журнала:
2024,
Номер
14(11), С. 604 - 604
Опубликована: Ноя. 8, 2024
Metabolic
cancers
are
defined
by
metabolic
reprogramming.
Although
this
reprograming
drives
rapid
tumour
growth
and
invasion,
it
also
reveals
specific
vulnerabilities
that
can
be
therapeutically
exploited
in
cancer
therapy.
A
novel
form
of
programmed
cell
death,
known
as
disulfidptosis,
was
identified
last
year;
cells
with
high
SLC7A11
expression
undergo
disulfidptosis
when
deprived
glucose.
Natural
products
have
attracted
increasing
attention
shown
potential
to
treat
through
diverse
mechanisms.
Nutrition Reviews,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 19, 2025
Abstract
Owing
to
the
developments
in
various
therapeutic
modalities,
cancer
treatment
has
come
a
long
way,
including
discovery
of
anticancer
drugs,
innovations
delivery
technology,
and
increased
personalization
treatments.
Despite
this,
head
neck
(HNC)
is
that
eluded
current
conventional
To
improve
quality
life
preserve
vital
organ
function
patients
with
HNC,
there
need
for
research
into
regimes
would
reduce
toxicity
modalities.
The
use
single
approach
not
been
enough
completely
eradicate
this
malignancy.
Therefore,
adjuvants
combinatorial
approaches,
using
molecules
from
natural
compounds
have
no
or
minimal
side
effects,
growing
area
research.
One
objective
review
was
clarify
potentiality
novel
strategies
such
as
phytochemicals
chemotherapy
radiotherapy,
nano-formulation
delivery.
Another
delineate
associated
challenges
clinical
application
these
therapies
HNC.
Possible
overcoming
critical
issues
HNC
are
also
discussed.
Cancers,
Год журнала:
2025,
Номер
17(8), С. 1269 - 1269
Опубликована: Апрель 9, 2025
Background/Objectives:
Head
and
neck
cancer
is
one
of
the
most
common
cancers
globally,
with
high
mortality
significant
treatment-related
side
effects.
Conventional
therapies,
including
surgery,
radiotherapy,
chemotherapy,
have
improved
survival
but
often
serious
consequences
for
patients’
quality
life.
For
this
reason,
there
growing
interest
in
complementary
therapies
such
as
acupuncture,
herbal
medicine,
cannabinoids,
traditional
Chinese
mind-body
therapies.
Methods:
This
review
was
conducted
through
a
systematic
analysis
scientific
literature
available
on
PubMed
Scopus,
selecting
studies
about
use
alternative
patients
head
according
to
strict
criteria.
Results:
Acupuncture
has
shown
benefits
management
xerostomia
dysphagia,
while
some
medicines
potential
anticancer
effects,
although
limitations
related
bioavailability.
Vitamins
antioxidants
showed
mixed
results:
suggest
protective
effect,
others
report
possible
increased
risk
progression.
Cannabinoids
are
controversial
topic,
palliative
also
higher
cancer.
Traditional
medicine
yoga,
positive
effects
well-being,
their
direct
impact
progression
remains
uncertain.
Conclusions:
Alternative
could
be
useful
support
managing
symptoms
improving
life
However,
solid
evidence
effectiveness
safety
still
lacking.
Rigorous
clinical
needed
assess
therapeutic
define
safe
integration
into
multidisciplinary
management.
Journal of Translational Medicine,
Год журнала:
2025,
Номер
23(1)
Опубликована: Апрель 16, 2025
Oral
Lichen
Planus
(OLP)
is
a
chronic
inflammatory
disorder
that
may
progress
to
Squamous
Cell
Carcinoma
(OSCC).
Lipid
metabolism
dysregulation
has
been
implicated
in
tumor
development
and
immune
response
modulation.
This
study
aims
explore
the
role
of
lipid
metabolism,
particularly
lipids
diacylglycerol
(DAG),
triacylglycerol
(TAG),
phosphatidylcholine
(PC),
progression
from
OLP
OSCC,
identify
potential
therapeutic
targets
for
prevention
treatment.
We
performed
Mendelian
randomization
(MR)
analysis
investigate
causal
relationships
between
risk
OSCC.
Differential
gene
expression
was
conducted
key
genes
related
metabolism.
The
interactions
species
were
examined
using
drug
databases
(DrugBank,
DGIdb,
TCMSP)
candidates.
Enrichment
signaling
pathways,
including
PPAR
signaling,
also
understand
underlying
mechanisms.
Our
MR
revealed
DAG
exerts
protective
effect
(OR
<
1),
but
its
shifts
factor
OSCC
>
potentially
by
altering
microenvironment.
TAG
PI
plays
critical
tumorigenesis.
Gene
identified
several
metabolism-related
genes,
SLC27A6,
FABP3,
FABP4,
ADIPOQ,
PLIN1,
whose
differed
highlighting
their
importance
progression.
These
enriched
pathway,
suggesting
involvement
growth
Potential
candidates,
such
as
palm
acid
(PA),
Imatinib,
Curcumin,
through
drug-repurposing
strategies.
crucial
Targeting
pathways
DAG,
TAG,
PI,
offer
promising
strategies
early
diagnosis
intervention.
provides
novel
insights
into
molecular
mechanisms
OLP-to-OSCC
suggests
natural
compounds,
future
clinical
applications.
Further
research
needed
validate
these
findings
settings.
Not
applicable.
Antioxidants,
Год журнала:
2025,
Номер
14(5), С. 508 - 508
Опубликована: Апрель 24, 2025
Oxidative
stress
serves
as
both
a
driver
and
result
of
redox
metabolism
across
diverse
physiological
pathological
states,
including
cancer.
Head
neck
squamous
cell
carcinoma
(HNSCC),
the
sixth
most
prevalent
malignancy
worldwide,
is
no
exception.
HNSCC
strongly
linked
to
modifiable
external
risk
factors
such
tobacco
smoking,
alcohol
consumption,
high-risk
human
papilloma
(HR-HPV)
infection.
These
are
associated
with
elevated
oxidative
stress,
which
contributes
carcinogenesis
through
DNA
damage,
chronic
inflammation,
dysregulation
signaling
pathways.
Current
treatment
options
for
have
limitations
burden
side
effects.
Studies
been
conducted
on
potent
dietary
antioxidants
prevention
adjunctive
HNSCC.
This
review
aims
explore
contribution
in
general
three
major
We
evaluate
latest
evidence
nine
vitamin
C,
E,
carotenoids,
epigallocatechin-3-gallate
(EGCG),
curcumin,
that
shown
promise
preclinical
clinical
studies.
discuss
how
these
compounds
mitigate
ROS,
influence
cancer-related
pathways,
modulate
tumor
microenvironment.
Despite
encouraging
findings,
current
data
remain
limited
inconclusive,
highlighting
need
further
research
possible
