Nutrients,
Год журнала:
2024,
Номер
16(7), С. 924 - 924
Опубликована: Март 23, 2024
Chlorogenic
acid
(CGA)
is
a
type
of
polyphenol
compound
found
in
rich
concentrations
many
plants
such
as
green
coffee
beans.
As
an
active
natural
substance,
CGA
exerts
diverse
therapeutic
effects
response
to
variety
pathological
challenges,
particularly
conditions
associated
with
chronic
metabolic
diseases
and
age-related
disorders.
It
shows
multidimensional
functions,
including
neuroprotection
for
neurodegenerative
disorders
diabetic
peripheral
neuropathy,
anti-inflammation,
anti-oxidation,
anti-pathogens,
mitigation
cardiovascular
disorders,
skin
diseases,
diabetes
mellitus,
liver
kidney
injuries,
anti-tumor
activities.
Mechanistically,
its
integrative
functions
act
through
the
modulation
anti-inflammation/oxidation
homeostasis.
can
thwart
inflammatory
constituents
at
multiple
levels
curtailing
NF-kB
pathways
neutralize
primitive
factors,
hindering
propagation,
alleviating
inflammation-related
tissue
injury.
concurrently
raises
pivotal
antioxidants
by
activating
Nrf2
pathway,
thus
scavenging
excessive
cellular
free
radicals.
elevates
AMPK
maintenance
restoration
homeostasis
glucose
lipids.
Additionally,
neuromodulation
targeting
neuroreceptors
ion
channels.
In
this
review,
we
systematically
recapitulate
CGA’s
pharmacological
activities,
medicinal
properties,
mechanistic
actions
potential
agent.
Further
studies
defining
specific
molecules,
improving
bioavailability,
validating
clinical
efficacy
are
required
corroborate
CGA.
Journal of Agricultural and Food Chemistry,
Год журнала:
2024,
Номер
72(21), С. 12184 - 12197
Опубликована: Май 15, 2024
Oolong
tea
polyphenols
(OTP)
have
attracted
wide
attention
due
to
their
ability
reduce
inflammatory
response,
regulate
gut
microbiota,
and
improve
cognitive
function.
However,
exactly
how
the
microbiota
modulates
nervous
system
activity
is
still
an
open
question.
We
previously
expounded
that
supplementing
with
OTP
alleviated
neuroinflammation
in
circadian
rhythm
disorder
(CRD)
mice.
Here,
we
showed
can
relieve
microglia
activation
by
reducing
harmful
microbial
metabolites
lipopolysaccharide
(LPS)
alleviate
CRD-induced
decline.
Mechanistically,
suppressed
inflammation
response
regulating
composition,
including
upregulating
relative
abundance
of
Molecular Nutrition & Food Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 9, 2025
ABSTRACT
Phenolic
compounds,
abundantly
found
in
medicinal
herbs,
may
promote
health
by
modulating
the
gut
microbiota.
Yarrow
is
a
traditional
remedy
for
digestive
and
non‐gastrointestinal
diseases
with
unexplored
interaction
microbes.
This
study
aimed
to
evaluate
effects
of
yarrow
extract
phenolic
mixture
comprising
apigenin,
caffeic,
chlorogenic
acids
on
microbiota
using
TIM‐2
vitro
system.
The
units
were
inoculated
fecal
samples
from
healthy
individuals
supplemented
test
substrates
72
h.
Microbiota
composition
was
assessed
V
3
‐V
4
16S
rRNA
gene
sequencing,
while
organic
acid
production
evaluated
GC‐MS.
stimulated
probiotic
bacteria
Lactiplantibacillus
,
other
abundant
symbiotic
inhabitants,
including
Eggerthellaceae,
Christensenellaceae,
Butyricicoccaceae,
Eubacterium
coprostanoligenes
group.
exerted
milder
enhancing
growth
Eggerthellaceae
Collinsella
.
Looking
at
microbial
activity,
SCFAs,
specifically
acetic
propionic
acids,
increased
obtained
results
highlight
importance
phenolics
maintaining
balance.
specific
modulate
promoting
SCFA
producers
stimulating
synthesis.
This
study
explores
honey
as
a
natural
remedy
for
sleep
disorders,
highlighting
its
unique
properties
and
soothing
effects.
The
findings
suggest
that
may
improve
quality
without
drugs,
though
more
research
is
needed
on
holistic
use.
Journal of Functional Foods,
Год журнала:
2024,
Номер
120, С. 106378 - 106378
Опубликована: Авг. 3, 2024
Prebiotic
demand
is
increasing
due
to
growing
concerns
about
human
gut
health
and
well-being.
Recently,
agri-food
by-products
have
been
explored
as
a
potential
source
of
prebiotic
ingredients.
This
study
analysed
the
chemical
composition
freeze-dried
coffee
silverskin
extract
(FSE)
evaluated
its
impact
on
Lacticaseibacillus
paracasei
subsp.
BAA-52
ATCC
growth.
The
FSE
was
obtained
by
multi-frequency
multimode
modulation
ultrasonic
vibration.
Soluble
dietary
fiber
accounted
for
15.2
%
extract,
being
mainly
composed
uronic
acids
(58
mol%)
glucose
(13.4
mol%).
HPLC-DAD-MS-ESI+
HPLD-DAD
analyses
revealed
phenolic-rich
(mainly
caffeoylquinic
acids),
well
presence
caffeine,
5-hydroxymethylfurfural.
probiotic
incubated
in
De
Man,
Rogosa,
Sharpe
broth
supplemented
with
different
concentrations
(1–4
%,
w/v).
2
4
(w/v)
significantly
enhanced
L.
subs.
growth
decreased
pH
medium,
indicating
ingredient.
