International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(23), С. 12701 - 12701
Опубликована: Ноя. 26, 2024
Foeniculum
vulgare
Mill,
commonly
known
as
fennel,
is
an
aromatic
herb
traditionally
used
for
culinary
and
medicinal
purposes,
with
potential
therapeutic
effects
on
neurological
disorders.
However,
limited
research
has
focused
its
neurotrophic
impact,
particularly
neuronal
maturation
synaptic
development.
This
study
investigates
the
of
F.
ethanol
extracts
(FVSE)
rat
primary
hippocampal
neurons.
Results
show
that
FVSE
prominent
component,
anethole,
significantly
promote
neurite
outgrowth
in
a
dose-dependent
manner.
Optimal
axonal
dendritic
growth
occurred
at
concentrations
40
µg/mL
20
µM
respectively,
without
causing
cytotoxicity,
underscoring
safety
health.
Additionally,
enhances
formation
synapses,
essential
communication.
Network
pharmacology
analysis
revealed
components
influence
critical
pathways,
including
PI3K-AKT
Alzheimer’s
disease
pathways.
Specifically,
modulates
key
proteins,
tropomyosin
receptor
kinase
(Trk),
glycogen
synthase
3
(GSK3βser9),
phosphatidylinositol
3-kinase
(PI3K),
extracellular
signal-regulated
protein
(Erk1/2).
Anethole
was
found
to
play
role
regulating
these
which
confirmed
by
immunocytochemistry
experiments
demonstrating
effect
promoting
In
conclusion,
this
highlights
properties
FVSE,
anethole
emerging
bioactive
compound.
These
findings
provide
valuable
insights
into
fennel
treating
disorders,
offering
basis
future
interventions
survival.
Antioxidants,
Год журнала:
2024,
Номер
13(4), С. 393 - 393
Опубликована: Март 25, 2024
The
aging
of
the
global
population
has
increased
prevalence
neurodegenerative
conditions.
Bacopa
monnieri
(BM),
an
herb
with
active
compounds,
such
as
bacosides
A
and
B,
betulinic
acid,
loliolide,
asiatic
quercetin,
demonstrates
potential
for
brain
health.
Limited
research
been
conducted
on
therapeutic
applications
BM
in
This
systematic
review
aims
to
project
BM’s
beneficial
role
disorders.
anti-apoptotic
antioxidant
actions
can
repair
damaged
neurons,
stimulate
kinase
activity,
restore
synaptic
function,
improve
nerve
transmission,
increase
neuroprotection.
included
twenty-two
clinical
trials
demonstrated
that
reduce
Nuclear
Factor-κB
phosphorylation,
emotional
cognitive
functions,
anhedonia,
hyperactivity,
sleep
routine,
depression,
attention
deficit,
learning
problems,
memory
retention,
impulsivity,
psychiatric
problems.
Moreover,
levels
pro-inflammatory
biomarkers
oxidative
stress.
Here,
we
highlight
provides
notable
benefits
serve
a
complementary
approach
care
patients
conditions
associated
adds
growing
interest
natural
products
their
by
improving
our
understanding
mechanisms
underlying
function
neurodegeneration
informing
development
new
strategies
diseases.
Foods,
Год журнала:
2024,
Номер
13(12), С. 1931 - 1931
Опубликована: Июнь 19, 2024
Over
the
past
decades,
there
has
been
a
significant
increase
in
burden
of
neurological
diseases,
including
neurodegenerative
disorders,
on
global
scale.
This
is
linked
to
widespread
demographic
trend
which
developed
societies
are
aging,
leading
an
increased
proportion
elderly
individuals
and,
concurrently,
number
those
afflicted,
posing
one
main
public
health
challenges
for
coming
decades.
The
complex
pathomechanisms
diseases
and
resulting
varied
symptoms,
differ
depending
disease,
environment,
lifestyle
patients,
make
searching
therapies
this
group
disorders
formidable
challenge.
Currently,
most
considered
incurable.
An
important
aspect
fight
against
prevention
may
be
broadly
understood
choices,
more
specifically,
what
we
will
focus
review,
diet.
One
proposal
that
help
spread
diet
rich
flavonoids.
Flavonoids
compounds
widely
found
products
healthy,
such
as
fruits,
vegetables,
herbs.
Many
studies
indicated
not
only
neuroprotective
effects
these
but
also
their
ability
reverse
changes
occurring
during
progression
Alzheimer’s,
Parkinson’s
amyotrophic
lateral
sclerosis.
Here,
present
groups
flavonoids,
discussing
characteristics
mechanisms
action.
described
point
functions
due
strong
antioxidant
anti-inflammatory
effects,
accompanied
with
penetrate
blood-brain
barrier,
well
inhibit
formation
protein
aggregates.
latter
feature,
together
promoting
removal
aggregates
especially
diseases.
We
discuss
therapeutic
potential
selected
flavonoids
based
vitro
studies,
impact
when
included
animals
(laboratory
research)
humans
(population
studies).
Thus,
review
summarizes
flavonoids’
actions
impacts
Therapeutic
use
future
potentially
possible
depends
overcoming
key
low
bioavailability,
determining
dose,
defining
flavonoid-rich
its
negative
effects.
suggests
further
research
directions
address
challenges.
Antioxidants,
Год журнала:
2024,
Номер
13(9), С. 1062 - 1062
Опубликована: Авг. 30, 2024
Neurodegenerative
diseases
encompass
a
spectrum
of
disorders
marked
by
the
progressive
degeneration
structure
and
function
nervous
system.
These
conditions,
including
Parkinson's
disease
(PD),
Alzheimer's
(AD),
Huntington's
(HD),
Amyotrophic
lateral
sclerosis
(ALS),
Multiple
(MS),
often
lead
to
severe
cognitive
motor
deficits.
A
critical
component
neurodegenerative
pathologies
is
imbalance
between
pro-oxidant
antioxidant
mechanisms,
culminating
in
oxidative
stress.
The
brain's
high
oxygen
consumption
lipid-rich
environment
make
it
particularly
vulnerable
damage.
Pro-oxidants
such
as
reactive
nitrogen
species
(RNS)
(ROS)
are
continuously
generated
during
normal
metabolism,
counteracted
enzymatic
non-enzymatic
defenses.
In
diseases,
this
balance
disrupted,
leading
neuronal
This
systematic
review
explores
roles
stress,
gut
microbiota,
epigenetic
modifications
aiming
elucidate
interplay
these
factors
identify
potential
therapeutic
strategies.
We
conducted
comprehensive
search
articles
published
2024
across
major
databases,
focusing
on
studies
examining
relationships
redox
homeostasis,
changes
neurodegeneration.
total
161
were
included,
comprising
clinical
trials,
observational
studies,
experimental
research.
Our
findings
reveal
that
stress
plays
central
role
pathogenesis
with
microbiota
composition
significantly
influencing
balance.
Specific
bacterial
taxa
markers
identified
modulators
suggesting
novel
avenues
for
intervention.
Moreover,
recent
evidence
from
human
animal
supports
emerging
concept
targeting
homeostasis
through
therapies.
Future
research
should
focus
validating
targets
settings
exploring
personalized
medicine
strategies
based
individual
profiles.
Food Science & Nutrition,
Год журнала:
2025,
Номер
13(3)
Опубликована: Март 1, 2025
ABSTRACT
Phytochemicals
are
bioactive
compounds
found
in
plants
that
play
a
key
role
promoting
health
and
preventing
diseases.
Present
fruits,
vegetables,
grains,
seed
oils,
these
considered
safe
for
consumption
due
to
the
co‐evolution
adaptation
between
mammals
plants.
Due
their
wide‐ranging
biological
effects,
they
have
attracted
considerable
research
interest.
This
comprehensive
review
explores
mechanisms
of
action,
benefits,
applications
dietary
phytochemicals,
with
particular
focus
on
groups
such
as
polyphenols,
flavonoids,
carotenoids.
Research
shows
phytochemicals
interact
nuclear
membrane
receptors,
influence
metabolic
pathways,
affect
epigenetic
modifications.
Our
highlights
broad
range
activities
compounds,
including
antioxidant,
antibacterial,
anti‐inflammatory,
anti‐diabetic,
anticancer
all
which
contribute
health‐promoting
properties.
Clinical
evidence
supports
prevention
management
diseases
cardiovascular
disorders,
conditions,
cancer,
diets
rich
being
linked
lower
risk
disease.
also
at
cutting
edge
food
preservation,
supplements,
emerging
medical
treatments.
Additionally,
we
identified
advancements
extraction
identification
techniques,
particularly
metabolomics,
further
enhance
areas.
Despite
promising
challenges
bioavailability,
regulatory
barriers,
need
robust
clinical
trials
persist.
However,
innovative
delivery
systems
like
nanoparticles,
liposomes,
encapsulation
offer
potential
solutions
bioavailability
by
improving
absorption
stability.
The
concludes
emphasizing
personalized
nutrition
combination
therapies
benefits
while
stressing
methods,
trials,
bioavailability.
Biotechnology Reports,
Год журнала:
2025,
Номер
45, С. e00881 - e00881
Опубликована: Фев. 8, 2025
Despite
broad
spectrum
utility
of
Nardostachys
jatamansi
(D.
Don)
DC,
little
is
known
about
the
molecular
processes
that
underlie
its
anti-Alzheimer
action.
To
investigate
targets
and
therapeutic
potential
N.
for
Alzheimer's
disease
(AD),
we
used
Gas
Chromatography-Mass
Spectrometry
(GC-MS),
ADMET
analysis,
network
pharmacology,
differential
gene
expression
docking,
dynamics
(MD)
simulations.
The
STITCH
database
was
creation
protein-protein
interaction
while
Cytoscape
visualization
Kyoto
Encyclopedia
Genes
Genomes
(KEGG)
pathway
enrichment
Gene
Ontology
(GO)
term
enrichment.
Additionally,
to
intermolecular
interactions
between
active
chemicals
target
proteins,
docking
experiments
were
conducted
using
Blind
on
Achilles
server.
stability
PS1
complex
with
Spirojatamol,
further
evaluated
MD
With
Spirojatamol
showing
highest
binding
energy
scores
against
(-6.9
kcal/mol),
confirmed
activity
this
metabolite
AD
formed
a
stable
at
100
nanoseconds,
according
additional
investigation
Significant
ligand-protein
verified
by
free
calculations
MM/GBSA
technique.
PS1-Spirojatamol
had
ΔG:
-36.95
±
5.00
kcal/mol.
By
focusing
several
genes
pathways,
involved
in
AD,
work
reveals
underpinnings
behind
possible
use
treatment
AD.
Brain Sciences,
Год журнала:
2025,
Номер
15(3), С. 252 - 252
Опубликована: Фев. 27, 2025
Neurological
disorders
are
defined
by
a
deterioration
or
disruption
of
the
nervous
system’s
structure
and
function.
These
diseases,
which
include
multiple
sclerosis,
Alzheimer’s
disease,
Parkinson’s
Huntington’s
schizophrenia,
caused
intricate
pathological
processes
that
excitotoxicity,
neuroinflammation,
oxidative
stress,
genetic
mutations,
compromised
neurotrophic
signaling.
Although
current
pharmaceutical
treatments
relieve
symptoms,
their
long-term
efficacy
is
limited
due
to
adverse
side
effects
weak
neuroprotective
properties.
However,
when
combined
with
other
drugs
adjunct
therapy,
they
may
offer
additional
benefits
improve
treatment
outcomes.
Phytochemicals
have
emerged
as
attractive
therapeutic
agents
ability
regulate
essential
pathways,
especially
brain-derived
factor
(BDNF)
signaling
cascade.
BDNF
an
important
target
for
neurodegenerative
disease
(ND)
since
it
regulates
neuronal
survival,
synaptic
plasticity,
neurogenesis,
neuroprotection.
This
review
emphasizes
molecular
pathways
through
various
phytochemicals—such
flavonoids,
terpenoids,
alkaloids,
phenolic
compounds—stimulate
expression
modulate
its
downstream
including
GSK-3β,
MAPK/ERK,
PI3K/Akt/mTOR,
CREB,
Wnt/β-catenin.
paper
also
highlights
how
phytochemical
combinations
interact
enhance
activity,
offering
new
options
ND
treatment.
Despite
potential
neuroprotection,
phytochemicals
face
challenges
related
pharmacokinetics,
blood–brain
barrier
(BBB)
permeability,
absorption,
highlighting
need
further
research
into
combination
therapies
improved
formulations.
Clinical
assessment
mechanistic
understanding
BDNF-targeted
phytotherapy
should
be
main
goals
future
studies.
The
natural
compounds
in
regulating
highlighted
this
review,
providing
viable
approach
prevention
NDs.
