The Interplay between Ferroptosis and Neuroinflammation in Central Neurological Disorders

Antioxidants, Год журнала: 2024, Номер 13(4), С. 395 - 395

Опубликована: Март 26, 2024

Central neurological disorders are significant contributors to morbidity, mortality, and long-term disability globally in modern society. These encompass neurodegenerative diseases, ischemic brain traumatic injury, epilepsy, depression, more. The involved pathogenesis is notably intricate diverse. Ferroptosis neuroinflammation play pivotal roles elucidating the causes of cognitive impairment stemming from these diseases. Given concurrent occurrence ferroptosis due metabolic shifts such as iron ROS, well their critical central nervous disorders, investigation into co-regulatory mechanism has emerged a prominent area research. This paper delves mechanisms along with interrelationship. It specifically emphasizes core molecules within shared pathways governing neuroinflammation, including SIRT1, Nrf2, NF-κB, Cox-2, iNOS/NO·, how different immune cells structures contribute dysfunction through mechanisms. Researchers’ findings suggest that mutually promote each other may represent key factors progression disorders. A deeper comprehension common pathway between cellular holds promise for improving symptoms prognosis related

Язык: Английский

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Formononetin protects against Aspergillus fumigatus Keratitis: Targeting inflammation and fungal load

International Immunopharmacology, Год журнала: 2024, Номер 132, С. 112046 - 112046

Опубликована: Апрель 9, 2024

Язык: Английский

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Bioactive Fraction of Processed Curcumae Rhizoma-Sparganii Rhizoma Anti-Liver Fibrosis by Regulate Taurine Metabolism Through Pi3k/Akt Pathway

Опубликована: Янв. 1, 2025

Язык: Английский

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Potential protective role of Lycium ruthenicum Murray polysaccharides against lipopolysaccharide-induced liver injury via mitochondrial biogenesis

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 141365 - 141365

Опубликована: Фев. 1, 2025

Язык: Английский

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Formononetin: a review of its source, pharmacology, drug combination, toxicity, derivatives, and drug delivery systems

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Март 3, 2025

Formononetin (FMN) is a common natural metabolite that can be extracted and isolated from some botanical drugs. In recent years, FMN has garnered increasing attention due to its beneficial biological activities. this paper, we systematically summarize the sources of provide comprehensive review pharmacological activities molecular mechanisms, co-administration, toxicity, derivatives, drug delivery systems in last 5 years. The study results found wide range neurological disorders, organ damage cancer, showing great potential for clinical application broad prospects. Researchers are exploring various types systems, including nanoparticle carriers, ligand modifications polymer microspheres. These advanced enhance stability FMN, prolong release time vivo , improve targeting, thereby optimizing therapeutic efficacy reducing side effects, greatly improving bioavailability. conclusion, with considerable research value, diverse make it promising candidate development medical research.

Язык: Английский

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Reversed role of CD36 deficiency in high-fat diet or methionine/choline-deficient diet-induced hepatic steatosis and steatohepatitis

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Март 5, 2025

Cluster of differentiation 36 (CD36) is highly expressed in the liver patients with metabolic dysfunction-associated fatty disease (MAFLD) or steatohepatitis (MASH). However, precise role CD36 MAFLD/MASH controversial. In current study, we aimed to uncover early stage induced by high-fat diet (HFD) and methionine/choline-deficient (MCD) diet. CD36-/- mice littermate control were fed a normal food (NCD); HFD MCD for 6 weeks. We determined that deficiency attenuated HFD-induced hepatic steatosis while exacerbating diet-induced steatohepatitis. Mechanistically, reduced expression acid synthase (FASN), sterol regulatory element binding protein 1c (SREBP1c), acetyl-CoA carboxylase alpha (ACC1), thereby inhibiting de novo synthesis. The superoxide dismutase genes involving oxidation was inhibited oxidation, had no effect on these mice. Meanwhile, diet-reduced further deficiency. Thus, MCD-induced ROS inflammation enhanced By lipidomic analysis, found levels triglyceride (TG), diacylglycerols (DG), acylcarnitine (AcCA), ceramide (Cer) LPC increased, phosphatidylcholine/phosphatidylethanolamine (PC/PE) decreased diet-treated compared wild type Indeed, serine palmitoyltransferase 2 (SPTLC2), key rate-limiting enzyme synthesis, higher improves MAFLD accelerating MASH via promoting Cer, LPC, TG DG accumulation accelerate inflammation. complex needs more investigation discover effective strategy when targeting CD36.

Язык: Английский

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Insights into the Regulatory Effect of Danggui Buxue Tang in Postpartum Dairy Cows Through an Integrated Analysis of Multi-Omics and Network Analysis

Life, Год журнала: 2025, Номер 15(3), С. 408 - 408

Опубликована: Март 5, 2025

Postpartum dairy cows often face significant challenges due to metabolic disorders. Danggui Buxue Tang (DBT), a botanical drug composed of Astragali radix and Angelica sinensis in 5:1 ratio, has been recognized for its potential alleviate Its regulatory mechanisms on livestock health have remained unexplored. This study integrated the analyses serum pharmacochemistry, network pharmacology, metabolomics, fecal microbiota investigate effects DBT adaptation postpartum cows. Following oral administration DBT, levels blood non-esterified fatty acids beta-hydroxybutyrate were decreased multiparous one week after calving. Five absorbed prototype metabolites identified, specifically formononetin nicotinic acid, both which play roles regulation lipid homeostasis. Furthermore, modified composition gut microbial community glycerophospholipid levels. Decreases phosphatidylethanolamine phosphatidylcholine closely correlated with relative abundance Bacillus concentration circulating beta-hydroxybutyrate. These findings suggest that contributes positively by regulating metabolism, providing new insights into strategies promoting

Язык: Английский

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Dietary Polyunsaturated Fatty Acid Deficiency Impairs Renal Lipid Metabolism and Adaptive Response to Proteinuria in Murine Renal Tubules

Nutrients, Год журнала: 2025, Номер 17(6), С. 961 - 961

Опубликована: Март 10, 2025

Background/Objectives: Kidneys are fatty acid (FA)-consuming organs that use adenosine triphosphate (ATP) for tubular functions, including endocytosis protein reabsorption to prevent urinary loss. Peroxisome proliferator-activated receptor α (PPARα) is a master regulator of FA metabolism and energy production, with high renal expression. Although polyunsaturated acids (PUFAs) essential nutrients natural PPARα ligands, their role in remains unclear. As clinical PUFA deficiency occurs humans under various conditions, we used mouse model mimics these conditions. Methods: We administered 2-week intraperitoneal protein-overload (PO) treatment mice had been continuously fed PUFA-deficient diet. compared the phenotypic changes those standard diet supplementation. Results: In absence PO, induced increased lysosomal autophagy activation; however, other differences were not detected among groups. PO experimental condition, daily excretion lysosomes; suppressed adaptive activation, which was probably enhanced by continuous worsened PPARα-mediated responses disrupted homeostasis. However, attenuated supplementation at physiological intake level. Conclusions: PUFAs response against Therefore, active may be important patients kidney disease-associated proteinuria, especially deficiency-inducing

Язык: Английский

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Scutellarein ameliorates pulmonary arterial hypertension via sirtuin 1 mediated deacetylation of nicotinamide nucleotide transhydrogenase

Biochemical Pharmacology, Год журнала: 2025, Номер 237, С. 116932 - 116932

Опубликована: Апрель 6, 2025

Язык: Английский

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Integrated Metabolomics and Lipidomics Analysis Reveals the Mechanism Behind the Action of Chiglitazar on the Protection Against Sepsis-Induced Acute Lung Injury

Metabolites, Год журнала: 2025, Номер 15(5), С. 290 - 290

Опубликована: Апрель 25, 2025

Background: Sepsis-induced acute lung injury (SALI) is a critical clinical challenge with high mortality. Metabolic dysregulation drives SALI pathogenesis, disrupting function and energy metabolism. Despite proven benefits, metabolic restoration underused in sepsis. This study explores chiglitazar's role balancing metabolism to protect against SALI. Methods: The protective effects of chiglitazar CLP rats were demonstrated by the survival curve, histological analysis, immunohistochemical analysis tissue. Metabolomic lipidomic analyses tissue samples using gas chromatography-mass spectrometry (GC-MS) liquid (LC-MS) performed evaluate shifts induced surgery pretreatment. mRNA protein levels underlying targets directing nicotinamide adenine dinucleotide (NAD+) triglyceride synthesis analyzed qPCR Western blotting. To validate mechanism which protected SALI, SIRT1 inhibitor EX-527 was applied human normal epithelial (BEAS-2B) cells another batch observe its reverse effect action. Results: Chiglitazar pretreatment significantly restored NAD+ improved dysregulated lipid enhancing triglycerides (TGs) suppressing accumulated fatty acids (FAs). modulation mediated associated upregulations SIRT1/PGC-1α/PPARα/GPAT3 axis. Co-treatment LPS-stimulated BEAS-2B inhibited on aforementioned signaling pathways worsened injury, respectively. Conclusions: alleviates restoring TG synthesis, highlighting as promising therapeutic strategy management

Язык: Английский

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