International Journal of Biological Sciences,
Год журнала:
2024,
Номер
20(13), С. 5145 - 5161
Опубликована: Янв. 1, 2024
Non-small
cell
lung
cancer
(NSCLC),
a
major
subtype
of
cancer,
encompasses
squamous
carcinoma,
adenocarcinoma,
and
large
carcinoma.
Compared
to
small
NSCLC
cells
grow
divide
more
slowly,
their
metastasis
occurs
at
later
stage.
Currently,
chemotherapy
is
the
primary
treatment
for
this
disease.
Sappanone
A
(SA)
flavonoid
compound
extracted
from
plant
Caesalpinia
sappan,
known
its
antitumor,
redox-regulating,
anti-inflammatory
properties.
Recent
studies
have
investigated
interaction
SA
with
mitochondrial
pathways
in
regulating
death
through
Nrf-2/GPX-4/xCT
axis.
This
study
specifically
explores
mechanism
by
which
affects
morphology
structure
regulation
mitophagy
biogenesis
tumor
cells.
The
primarily
utilizes
second-generation
transcriptomic
sequencing
data
molecular
docking
techniques
elucidate
role
programmed
omics
results
indicate
that
significantly
targets
genes
involved
oxidative
phosphorylation,
mitophagy,
dynamics,
stress.
Further
findings
confirmed
Nrf-2/GPX4/xCT
pathway
serves
as
crucial
target
NSCLC.
Knockdown
Nrf-2
(si-Nrf-2)
overexpression
(ad-Nrf-2)
were
shown
modulate
therapeutic
efficacy
varying
degrees.
Additionally,
modifications
GPX4/xCT
affected
regulatory
effects
on
autophagy,
biogenesis,
energy
metabolism.
These
mechanisms
may
be
mediated
caspase
ferroptosis-related
signaling.
Molecular
biology
experiments
demonstrated
intervention
further
inhibits
phosphorylation
FUNDC1
Tyr18
downregulates
TOM20
expression.
was
found
reduce
expression
PGC1α,
Nrf-1,
Tfam,
resulting
decrease
respiration
Overexpression
counteract
biogenesis.
Confocal
microscopy
revealed
increases
fragmentation,
subsequently
inducing
pathway-mediated
death.
However,
genetic
modification
altered
In
conclusion,
has
been
identified
promising
agent
apoptosis
ferroptosis
represent
key
Targeting
axis
offers
novel
approach
maintaining
homeostasis
within
cellular
microenvironment.
Antioxidants,
Год журнала:
2024,
Номер
13(6), С. 651 - 651
Опубликована: Май 27, 2024
Alzheimer’s
disease
(AD)
is
a
stealthy
and
progressive
neurological
disorder
that
leading
cause
of
dementia
in
the
global
elderly
population,
imposing
significant
burden
on
both
society.
Currently,
condition
treated
with
medications
alleviate
symptoms.
Nonetheless,
these
drugs
may
not
consistently
produce
desired
results
can
serious
side
effects.
Hence,
there
vigorous
pursuit
alternative
options
to
enhance
quality
life
for
patients.
Ginkgo
biloba
(GB),
an
herb
historical
use
traditional
medicine,
contains
bioactive
compounds
such
as
terpenoids
(Ginkgolides
A,
B,
C),
polyphenols,
organic
acids,
flavonoids
(quercetin,
kaempferol,
isorhamnetin).
These
are
associated
anti-inflammatory,
antioxidant,
neuroprotective
properties,
making
them
valuable
cognitive
health.
A
systematic
search
across
three
databases
using
specific
keywords—GB
AD
dementia—yielded
1702
documents,
selection
15
clinical
trials
synthesis.
In
eleven
studies,
GB
extract/EGb
761®
was
shown
improve
function,
neuropsychiatric
symptoms,
functional
abilities
types.
four
however,
were
no
differences
between
GB-treated
placebo
groups.
Significant
improvements
observed
scores
obtained
from
Mini-Mental
State
Examination
(MMSE),
Short
Cognitive
Performance
Test
(SKT),
Neuropsychiatric
Inventory
(NPI).
While
majority
synthesized
show
has
promising
potential
treatment
conditions,
more
research
needed
determine
optimal
dosages,
effective
delivery
methods,
appropriate
pharmaceutical
formulations.
Furthermore,
thorough
assessment
adverse
effects,
exploration
long-term
implications,
investigation
into
drug
interactions
critical
aspects
must
be
carefully
evaluated
future
studies.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Июнь 21, 2024
The
drug
development
process
is
poised
for
significant
transformation
due
to
the
rapid
advancement
of
modern
biological
and
information
technologies,
such
as
artificial
intelligence
(AI).
As
these
new
technologies
concepts
infiltrate
every
stage
development,
efficiency
success
rate
research
are
expected
improve
substantially.
Traditional
Chinese
medicine
(TCM),
a
time-honored
therapeutic
system
encompassing
herbal
medicine,
acupuncture,
qigong,
will
also
be
profoundly
impacted
by
advancements.
Over
next
decade,
encounter
both
opportunities
challenges
it
integrates
with
concepts.
By
2035,
TCM
anticipated
merge
through
more
contemporary
open
model,
providing
substantial
support
treating
broader
spectrum
diseases.
Food Chemistry,
Год журнала:
2024,
Номер
461, С. 141018 - 141018
Опубликована: Авг. 28, 2024
Fermentation
enhances
the
nutritional
profile
of
foods
and
beverages
like
beer,
wine,
fermented
teas.
Ginkgo
biloba,
long
utilized
for
its
health-enhancing
properties,
contains
bioactive
compounds
terpene
trilactones
flavonoids,
known
their
antioxidant
neuroprotective
effects.
This
study
explores
feasibility
using
dried
biloba
leaves
in
SCOBY-mediated
fermentation
to
produce
novel
health-promoting
similar
kombucha.
Infusions
with
varying
sugar
concentrations
are
over
21
days.
Results
showed
that
these
exhibited
potent
notably
higher
than
tea-kombucha,
attributed
increased
polyphenol
content.
HPLC
analysis
identified
significant
levels
such
as
catechin
apigenin.
Sensory
evaluation
highlighted
optimal
acceptance
seven-day
product.
research
underscores
potential
a
functional
ingredient
beverages,
offering
healthier
alternative
conventional
soft
drinks.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(1), С. 332 - 332
Опубликована: Янв. 2, 2025
Myopia
is
one
of
the
dominant
causes
visual
impairment
in
world.
Pathological
myopia
could
even
lead
to
other
serious
eye
diseases.
Researchers
have
reached
a
consensus
that
be
caused
by
both
environmental
and
genetic
risk
factors.
Exploring
pathological
mechanism
can
provide
scientific
basis
for
developing
measures
delay
progression
or
treat
it.
Recent
advances
highlight
scleral
hypoxia
an
important
factor
promoting
myopia.
In
this
review,
we
summarized
role
pathology
also
provided
interventions
target
directly
indirectly.
We
hope
review
will
aid
development
novel
therapeutic
strategies
drugs
PLoS ONE,
Год журнала:
2025,
Номер
20(2), С. e0314644 - e0314644
Опубликована: Фев. 14, 2025
This
study
aims
to
analyse
the
efficacy
of
GBE
administration
in
patients
with
glaucoma
and
healthy
volunteers.
systematic
review
was
performed
according
PRISMA
2020
guidelines.
All
clinical
studies
investigating
on
intraocular
pressure
(IOP),
corrected
pattern
standard
deviation
(CPSD)
mean
visual
field
testing,
heart
rate
were
considered.
The
weighted
difference
(MD)
effect
measure,
95%
confidence
interval
(CI),
t-test
used
for
continuous
variables.
Data
from
8
studies,
including
428
patients,
retrieved.
age
all
51.1
±
15.5
years.
median
follow-up
3.7
(IQR
9.4)
months.
not
associated
an
improvement
IOP
(MD
-1.5;
95%CI
-7.1
9.6;
P
=
0.5),
0.7;
-9.4
8.2;
0.8),
CPSD
-1.6;
-3.8
6.9;
or
-2.5;
-11.5
16.5;
0.4)
baseline
last
follow-up.
There
no
between
versus
control
group
1.1;
-5.7
3.5;
0.4),
-0.4;
-9.1
9.9;
0.9),
0.3;
-6.8
6.2;
-1.3;
-15.1
17.7;
0.8)
at
Currently,
evidence
is
sufficient
conclude
that
affects
IOP,
deviation,
CPSD,
These
conclusions
must
be
interpreted
caution
given
limitations
reviewed
particularly
time
included
studies.
Applied Sciences,
Год журнала:
2024,
Номер
14(22), С. 10231 - 10231
Опубликована: Ноя. 7, 2024
Ginkgo
(Ginkgo
biloba
L.)
is
a
widely
used
medicinal
plant,
with
its
green
spring
leaves
commonly
utilized
for
preparing
extracts
various
therapeutic
properties,
and
leaf
infusions
also
frequently
employed.
This
study
aimed
to
evaluate
the
in
vitro
neuroprotective,
anti-hyperpigmentation,
anti-diabetic,
antioxidant
activities,
as
well
flavonoid
content
bioaccessibility,
of
ginkgo
infusions,
comparing
collected
autumn.
Infusions
made
from
yellow
leaves,
both
those
directly
tree
fallen
exhibited
significantly
higher
total
polyphenol
(3.2-fold
2.5-fold,
respectively)
(3.1-fold
2.4-fold,
respectively),
along
greater
bioaccessibility
salivary
phase.
These
demonstrated
enhanced
tyrosinase
inhibition
(6.0-fold
5.7-fold,
activity
(4.8-fold
3.5-fold,
respectively).
Notably,
showed
2.5-fold
acetylcholinesterase
compared
while
α-glucosidase
remained
comparable
across
all
samples.
findings
suggest
that
including
have
fallen,
could
be
considered
valuable
material
making
potential
anti-diabetic
properties.
Deleted Journal,
Год журнала:
2024,
Номер
2, С. 100016 - 100016
Опубликована: Март 1, 2024
Liver
damage
resulting
from
the
administration
of
various
allopathic
drugs
and
their
associated
toxicity
has
become
a
major
health
problem,
leading
to
hepatic
fibrosis,
cirrhosis,
metabolic
disorders.
This
epidemic
condition
liver
disease
represents
global
cause
death
morbidity.
Although
orthotopic
transplantation
remains
vital
treatment
option
for
fibrotic
conditions,
its
efficacy
is
limited
by
organ
scarcity
risk
immunological
rejection.
Consequently,
alternative
therapeutic
approaches
are
urgently
needed.
Cell-based
therapy
utilizing
mesenchymal
stem
cells
(MSCs)
garnered
considerable
interest
as
promising
modality.
MSCs
exhibit
immunomodulatory
properties
can
differentiate
into
hepatocytes,
thus
facilitating
regeneration
damaged
hepatocytes
increasing
residual
hepatocyte
proliferation
while
inhibiting
activation
or
apoptosis
stellate
cells.
However,
despite
potential
benefits,
transplanted
often
low
survival
rates
due
inadequate
oxidative
inflammatory
stress
resistance.
Plants
harbor
diverse
array
bioactive
compounds
known
possess
hepatoprotective
antioxidant
properties.
Nanomaterials
play
crucial
role
in
regenerative
medicine
providing
targeted
delivery
agents
scaffolds
tissue
engineering.
In
treating
liver,
nanomaterials
help
mitigate
fibrosis
progression
promote
through
controlled
release
anti-fibrotic
growth
factors.
review
highlights
synergistic
cell-based
therapy,
natural
antioxidants,
differentiation
factors,
nanotechnology
combating
advancing
medicine.
These
combined
offer
avenues
effectively
conditions
promoting
regeneration.
