Liver
transplantation
is
a
life-saving
opportunity
for
patients
with
end-stage
liver
diseases
worldwide.There
are
two
types
of
transplants,
each
its
own
challenges.Even
brain
death
can
become
donors.Both
involve
preserving
and
reconstructing
vital
connections
this
essential
organ.Advances
in
field
offer
hope
those
advanced
diseases.An
analysis
transplants
Rio
de
Janeiro
over
14
years
aims
to
correlate
current
epidemiology
outcomes.Data
from
DATASUS
January
2008
December
2022
were
reviewed,
including
admissions,
public
expenditure,
complexity,
mortality,
deaths,
length
stay,
care,
as
well
articles
Scielo,
Lilacs,
PubMed.There
1,631
costing
R$146,798,794.70,
peak
terms
both
admissions
expenditure
(R$17,410,555.36).Of
these,
237
procedures
elective
1,394
urgent,
326
the
sector,
150
private
1,155
unknown
origin,
all
considered
high
complexity.The
overall
mortality
rate
was
11.89%,
194
deaths
recorded,
highest
being
2010
(25.93%)
lowest
2020
(6.25%).Mortality
higher
(12.24%)
sector
(19.94%)
compared
urgent
(11.84%)
(14.00%),
while
origin
had
9.35%.The
average
hospital
Lipid
metabolism
is
closely
linked
with
antitumor
immunity
and
autoimmune
disorders.
However,
the
precise
role
of
lipid
in
uveitis
pathogenesis
not
clear.
In
our
study,
we
analyzed
single-cell
RNA-Seq
(scRNA-Seq)
data
from
cervical
draining
lymph
nodes
(CDLNs)
mice
experimental
(EAU),
revealing
an
increased
abundance
fatty
acids
Th17
cells.
Subsequent
scRNA-Seq
analysis
identified
upregulation
DGAT1
expression
EAU
its
marked
reduction
under
various
immunosuppressive
agents.
Suppression
prevented
conversion
into
neutral
droplets,
resulting
accumulation
peroxidation
subsequent
proportion
Inhibiting
by
Ferrostatin-1
effectively
restored
cell
numbers
that
were
decreased
inhibitor.
Moreover,
validated
CD4+
T
cells
patients
Vogt-Koyanagi-Harada
(VKH)
disease,
a
human
uveitis.
induced
reduced
Collectively,
study
focused
on
elucidating
regulatory
mechanisms
underlying
survival
proposed
targeting
may
hold
promise
as
therapeutic
approach
for
Current Issues in Molecular Biology,
Год журнала:
2025,
Номер
47(4), С. 274 - 274
Опубликована: Апрель 14, 2025
When
subclinical
ketosis
(SCK)
occurs
in
dairy
cows,
it
leads
to
an
excessive
production
of
β-hydroxybutyrat
(BHBA),
which
disrupts
liver
lipid
metabolism
and
triggers
a
series
inflammatory
responses.
Rutin
(RT),
flavonoid
extracted
from
plants,
exhibits
diverse
biological
activities.
However,
its
potential
mitigate
BHBA-induced
inflammation
accumulation
cows
remains
unexplored.
In
this
study,
we
investigated
the
effect
RT
on
injury
hepatocytes
possible
mechanism.
First,
were
treated
with
BHBA
(0,
0.3,
0.6,
1.2,
2.4
mM)
assess
effects
impairment
accumulation.
Second,
pretreated
25,
50,
100,
150
μg/mL)
evaluate
protective
effects.
Third,
divided
into
five
treatment
groups:
blank
control,
treatment,
+
NF-κB
activator
(PDTC)
PDTC
treatment.
This
experiment
further
explored
underlying
mechanism
mitigating
hepatocyte
injury.
The
results
demonstrated
that
at
100
μg/mL
mitigated
increases
interleukin-1
beta
(IL-1β),
IL-6,
triglyceride
(TG),
total
cholesterol
(TC)
contents
induced
by
high
concentrations
(p
<
0.05).
Compared
significantly
downregulated
relative
protein
expression
P-NF-κB
p65
mRNA
p65,
tumor
necrosis
factor-alpha
(TNF-α),
IL-1β,
peroxisome
proliferator-activated
receptor
gamma
(PPARγ),
microsomal
transfer
(MTP),
while
upregulating
IKBα
Additionally,
these
more
pronounced
combined
pretreatment
RT.
conclusion,
inhibits
BHBA-triggered
modulating
signaling
pathway,
implying
may
be
promising
target
for
ameliorating
damage
SCK
cows.
Nutrients,
Год журнала:
2025,
Номер
17(9), С. 1495 - 1495
Опубликована: Апрель 29, 2025
In
animal
production,
nanoparticulate
zinc
oxide
exhibits
synergistic
antibacterial
efficacy
coupled
with
growth-promoting
effects,
positioning
itself
as
a
novel
antibiotic
alternative
enhanced
biosafety
profiles.
However,
its
dose-dependent
toxicity
poses
challenges.
Objective:
The
experimental
design
sought
to
quantify
the
protective
effects
of
dietary
rutin
against
zinc-overload-induced
damage.
Methods:
A
zinc-overload
murine
model
was
established
by
giving
high-dose
ZnO
nanoparticles
(HZn,
5000
mg/kg/day)
for
21
days.
Mice
were
then
fed
at
doses
300,
600,
or
1200
mg/kg.
Body
weight,
relative
organ
indexes,
concentrations,
serum
enzyme
activities,
and
tissue-level
indicators
apoptosis,
autophagy,
mitochondrial
function,
antioxidant
capacity
measured.
Results:
results
showed
that
could
not
reverse
HZn-induced
body
weight
decline
but
improved
indexes
in
liver
kidney.
It
alleviated
cell
damage
jejunum
through
Nrf2
activation,
without
inhibiting
elevation.
Conclusions:
Rutin,
especially
600
mg/kg,
can
partially
restore
hepatic
function
index
mitigate
jejunal
injuries.
Liver
transplantation
is
a
life-saving
opportunity
for
patients
with
end-stage
liver
diseases
worldwide.There
are
two
types
of
transplants,
each
its
own
challenges.Even
brain
death
can
become
donors.Both
involve
preserving
and
reconstructing
vital
connections
this
essential
organ.Advances
in
field
offer
hope
those
advanced
diseases.An
analysis
transplants
Rio
de
Janeiro
over
14
years
aims
to
correlate
current
epidemiology
outcomes.Data
from
DATASUS
January
2008
December
2022
were
reviewed,
including
admissions,
public
expenditure,
complexity,
mortality,
deaths,
length
stay,
care,
as
well
articles
Scielo,
Lilacs,
PubMed.There
1,631
costing
R$146,798,794.70,
peak
terms
both
admissions
expenditure
(R$17,410,555.36).Of
these,
237
procedures
elective
1,394
urgent,
326
the
sector,
150
private
1,155
unknown
origin,
all
considered
high
complexity.The
overall
mortality
rate
was
11.89%,
194
deaths
recorded,
highest
being
2010
(25.93%)
lowest
2020
(6.25%).Mortality
higher
(12.24%)
sector
(19.94%)
compared
urgent
(11.84%)
(14.00%),
while
origin
had
9.35%.The
average
hospital
