Journal of Ethnopharmacology,
Год журнала:
2024,
Номер
336, С. 118733 - 118733
Опубликована: Авг. 23, 2024
Smilax
glabra
rhizome
has
a
long
history
been
used
for
clinical
purposes
in
traditional
Chinese
medicinal
treating
various
inflammatory
conditions.
Engeletin
Pharmaceuticals,
Год журнала:
2025,
Номер
18(4), С. 468 - 468
Опубликована: Март 26, 2025
Background:
Acute
lung
injury
(ALI)
is
a
major
cause
of
death
in
patients
with
various
viral
pneumonias.
Our
team
previously
identified
four
volatile
compounds
from
aromatic
Chinese
medicines.
Based
on
molecular
compatibility
theory,
we
defined
their
combination
as
(AC),
though
its
therapeutic
effects
and
underlying
mechanisms
remain
unclear.
Methods:
This
study
used
influenza
A
virus
(IAV)
A/PR/8/34
to
construct
cell
mouse
models
ALI
explore
AC’s
protective
against
infection.
The
effect
AC
was
verified
by
evaluating
the
antiviral
efficacy
models,
including
improvements
colon
inflammation,
oxidative
stress,
suppression
NLRP3
inflammasome.
In
addition,
16S
rDNA
lipid
metabolomics
were
analyze
potential
AC.
Results:
vitro
vivo
studies
demonstrated
that
increased
survival
IAV-infected
cells
mice,
inhibited
replication
expression
proinflammatory
factors
tissues,
ameliorated
barrier
damage
colonic
tissues.
ROS
inflammasome
improved
inflammatory
infiltration
into
Finally,
effectively
regulated
intestinal
flora
disorders
metabolism
model
significantly
reduced
cholesterol
triglyceride
expression,
thus
abnormal
accumulation
droplets
(LDs)
after
IAV
Conclusions:
this
study,
could
treat
IAV-induced
ALIs
through
multiple
pathways,
anti-inflammatory
pathways
modulation
LDs.
Pharmaceuticals,
Год журнала:
2024,
Номер
17(12), С. 1700 - 1700
Опубликована: Дек. 17, 2024
Cinnamon
oil,
an
essential
oil
extracted
from
plants
of
the
genus
Cinnamomum,
has
been
highly
valued
in
ancient
Chinese
texts
for
its
medicinal
properties.
This
review
summarizes
chemical
composition,
pharmacological
actions,
and
various
applications
cinnamon
highlighting
potential
medical
industrial
fields.
By
systematically
searching
evaluating
studies
major
scientific
databases
including
Web
Science,
PubMed,
ScienceDirect,
we
provide
a
comprehensive
analysis
therapeutic
oil.
Research
indicates
that
possesses
wide
range
activities,
covering
antibacterial,
anti-inflammatory,
anti-tumor,
hypoglycemic
effects.
It
is
currently
active
ingredient
over
500
patented
medicines.
demonstrated
significant
inhibitory
effects
against
pathogens
comprising
Staphylococcus
aureus,
Salmonella,
Escherichia
coli.
Its
mechanisms
action
include
disrupting
cell
membranes,
inhibiting
ATPase
activity,
preventing
biofilm
formation,
suggesting
as
natural
antimicrobial
agent.
anti-inflammatory
properties
are
evidenced
by
ability
to
suppress
inflammatory
markers
like
vascular
adhesion
molecules
macrophage
colony-stimulating
factors.
Moreover,
shown
positive
lowering
blood
pressure
improving
metabolism
diabetic
patients
enhancing
glucose
uptake
increasing
insulin
sensitivity.
The
main
components
cinnamaldehyde,
cinnamic
acid,
eugenol,
which
play
key
roles
Recently,
fields,
food
preservation,
cosmetics,
fragrances,
have
also
become
increasingly
widespread.
Despite
extensive
research
supporting
value,
more
clinical
trials
needed
determine
optimal
dosage,
administration
routes,
possible
side
Additionally,
exploring
interactions
between
other
drugs,
well
safety
different
populations,
crucial.
Considering
current
increase
antibiotic
resistance
demand
sustainable
effective
treatments,
this
emphasizes
necessity
further
into
confirm
feasibility
basis
new
drug
development.
In
summary,
versatile
product,
holds
broad
application
prospects
expected
greater
role
future
practice.
Journal of Ethnopharmacology,
Год журнала:
2025,
Номер
unknown, С. 119436 - 119436
Опубликована: Фев. 1, 2025
Acute
lung
injury
(ALI)/acute
respiratory
distress
syndrome
(ARDS)
has
a
high
mortality
rate
and
often
occurs
in
sepsis.
Yantiao
Formula
(YTF)
is
used
effectively
clinic
but
its
mechanism
the
treatment
of
ALI
induced
by
sepsis
remains
unelucidated.
This
study
aims
to
explore
potential
molecular
mechanisms
YTF
sepsis-
ALI.
Using
ACQUITY
UPLC
I-Class,
chemical
components
contained
were
characterized.
The
network
pharmacology
approach
was
predict
targets
for
treating
induce
Single-cell
RNA
sequencing
(scRNA-seq)
find
changes
microenvironment
after
CLP-induced
Experimental
validation
also
performed
vitro
vivo.
docking,
we
speculated
on
pharmacological
substances
YTF.
We
detected
596
ingredients
identified
7
absorbed
prototypes
serum.
1031
retrieved
through
TCMSP
SwissTargetPrediction
databases.
365
identified.
observed
that
significantly
enriched
TNF
chemokine
related
pathway
using
GO
KEGG
analysis.
It
confirmed
at
different
time
points,
doses
increased
PaO2,
reduced
PaCO2
levels
W/D
ratio
tissue.
CLP-
decreased
survival
rates
improved
reversed
increase
IL-6
IL-1β
caused
CLP.
scRNA-seq
analysis,
found
proportion
cell
types
polarization
state
macrophages
evident.
Furthermore,
altered
biomarkers
(M1:
IL-1β,
iNOS
TNF-
α;
M2:
CD206/
Mrc1
Arg-1)
provided
evidence
polarization.
CLP-challenged
group
presented
enhanced
expression
CD206
Arg-1
immunohistochemical
Similarly,
same
results
validated
LPS-
NR8383
cells.
material
basis
therapeutic
demonstrated
docking.
release
inflammatory
factors
attenuated
sepsis-induced
combined
application
scRNA-seq,
docking
helpful
revealing
YTF,
which
altering
M1
M2
regulate
macrophage
role
exerting
effects
closely
relevant
binding
prototypes.
Microbiology Spectrum,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 29, 2024
ABSTRACT
Acute
lung
injury
(ALI)
is
associated
with
high
morbidity
and
mortality
rates.
However,
its
clinical
treatment
limited.
Currently,
the
of
diseases
by
regulating
microbiota
has
become
a
research
hotspot.
In
this
study,
we
investigated
protective
effects
intranasal
administration
Clostridium
butyricum
derived
extracellular
vesicles
(EVs)
against
lipopolysaccharide
(LPS)-induced
ALI.
The
results
demonstrated
that
compared
LPS
group,
pre-treatment
group
C.
EVs
reduced
expression
pro-inflammatory
cytokines
alleviated
symptoms
in
ALI
mice
inhibiting
TLR4/MyD88
signaling
pathway.
Moreover,
inhibited
apoptosis-related
proteins
increased
barrier
proteins.
Additionally,
intervention
changed
composition
pulmonary
microbiota.
At
species
level,
significantly
relative
abundance
Acinetobacter
johnsonii
,
while
reversed
effect.
conclusion,
these
data
demonstrate
can
prevent
LPS-induced
reducing
inflammation,
apoptosis,
improving
function.
regulated
to
alleviate
IMPORTANCE
disorder
plays
an
important
role
progression
acute
(ALI).
very
few
studies
have
been
conducted
treat
modulating
diversity
were
altered
mice,
but
ecological
balance
was
restored
.
study
reported
mechanism
for
These
reveal
importance
disease.
It
provides
new
approach
new-generation
probiotics.
Drug Design Development and Therapy,
Год журнала:
2024,
Номер
Volume 18, С. 6389 - 6411
Опубликована: Дек. 1, 2024
Qingre
Huoxue
Decoction
(QRHX)
is
a
classical
Chinese
herbal
prescription
widely
used
in
clinical
practice
for
the
treatment
of
atherosclerosis
(AS).
Our
previous
study
demonstrated
its
efficacy
stabilizing
plaque
and
improving
prognosis,
as
well
ability
to
regulate
macrophage
polarization.
This
aimed
further
investigate
effects
QRHX
on
AS
explore
underlying
mechanisms.
