Clinical significance and pathogenesis of GBP5 in infectious mononucleosis associated liver injury

˜The œItalian Journal of Pediatrics/Italian journal of pediatrics, Год журнала: 2025, Номер 51(1)

Опубликована: Март 12, 2025

Abstract Background Infectious mononucleosis (IM) is a common disease in children; however, liver injury its most complication. However, the pathogenesis of IM complicated with ambiguous. Thus, this study aimed to explore potential mechanism IM-associated injury. Methods This was conducted at Children’s Hospital Soochow University by collecting peripheral blood 70 hospitalized children IM. These patients were categorized into (LIG, n = 35) and non-liver groups (NLIG, 35), respectively. Subsequently, PBMCs plasma separated obtained. transcriptome sequencing performed two (5 cases each group), significantly differentially expressed genes (DEGs) screened. Additionally, GO function enrichment, KEGG enrichment GSEA analyses performed. RT-PCR helped detect relative GBP5, NLRP3 caspase-1 expressions (30 group) while groups’ caspase-1, IL-1β IL-18 levels measured ELISA. clinical laboratory datas 60 evaluated. Results Transcriptome results showed that 171 DEGs screened NLIG group, compared LIG. Among them, 154 up-regulated, 17 down-regulated, correlated NOD-like receptor signaling pathway. Statistically significant differences observed white cell lymphocyte counts, CD3 + CD4 T cells, CD8 alanine aminotransferase (ALT), aspartate transaminase (AST), lactate dehydrogenase (LDH) ( p < 0.05). Compared NLIG, PBMCs, as well levels, higher LIG 0.001). A correlation analysis revealed positive GBP5 LDH, ALT, AST, cells Conclusions Our findings demonstrate contributes through NLRP3-dependent

Язык: Английский

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Significance of FXR agonists in MASLD treatment: a deep dive into lipid alteration by analytical techniques

Опубликована: Март 25, 2025

Metabolic dysfunction-associated steatotic liver disease (MASLD) is rapidly emerging as a global health crisis, affecting over 30% of the population and demanding urgent attention. This redefined condition, previously known non-alcoholic fatty (NAFLD), reflects deeper understanding intricate interplay between metabolic dysfunction health. At heart MASLD lies troubling accumulation triglycerides (TGs) in hepatocytes, which precipitates insulin resistance oxidative stress, ultimately leading to more severe forms like steatohepatitis (MASH). Excitingly, recent research has spotlighted farnesoid X receptor (FXR) groundbreaking therapeutic target. FXR not only regulates lipid metabolism but also combats inflammation resistance, making it potential game-changer fight against MASLD. With one FDA-approved drug, resmetirom, currently available, exploration agonists opens new avenues for innovative treatments that could revolutionize patient care. By harnessing power restore balance integrating advanced strategies lipidomics acid profiling, we stand on brink transforming how approach its associated complications, paving way healthier future. review delves into promising role combating implications related disorders, emphasizing urgency detect manage this burgeoning epidemic.

Язык: Английский

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Metabolomics combined with network pharmacology reveals the protective effect of astragaloside IV on alcoholic liver disease

Phytomedicine, Год журнала: 2024, Номер unknown, С. 156032 - 156032

Опубликована: Сен. 1, 2024

Язык: Английский

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Mapping the relationship between alcohol use disorder and gut microbiota: a 20-year bibliometric study

Frontiers in Microbiology, Год журнала: 2024, Номер 15

Опубликована: Ноя. 18, 2024

Background Alcohol use disorder (AUD) is a psychiatric that widespread worldwide. significant contributor to the global burden of death, disability and disease. Modulation gut microbiota promising approach improve efficacy minimize adverse effects colorectal cancer treatment. The relationship between presence microbes AUD has been widely validated. However, few studies have examined this using bibliometric methods. Therefore, study analyzes research hotspots trends in human microbiology over last two decades from perspective. This aims at provide new directions for basic clinical field. Objective A comprehensive discussion current state intestinal flora. Methods We collected publications Web Science Core Collection database 2003 2023 according established inclusion criteria. analyzed countries, institutions, authors, contributions CiteSpace, VOSviewer, Scimago Graphics visualize Results total 2,102 were obtained, with rapid increase number since 2016. United States China are major contributors field network partners several countries. Five hundred ninety-five academic journals published articles on topic. author highest Prof. Bernd Schnabl Department Gastroenterology University California, San Diego. In addition “gut flora” “AUD,” high frequency words keyword co-occurrence analysis included alcoholic liver disease, tryptophan metabolism, enterohepatic axis, fecal microbial transplantation. Conclusion results visualization key areas past 20 years. suggest role its potential mechanisms, especially therapeutic targets, should be closely monitored could become hot topic

Язык: Английский

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The quassinoids bruceines A–M: pharmacology, mechanism of action, synthetic advance, and pharmacokinetics—a review

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2024, Номер 397(12), С. 9417 - 9433

Опубликована: Июль 10, 2024

Язык: Английский

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Bruceine A attenuates fibrogenesis and inflammation through NR2F2-regulated HMGB1 inflammatory signaling cascades in hepatic fibrosis

European Journal of Pharmacology, Год журнала: 2024, Номер unknown, С. 177164 - 177164

Опубликована: Ноя. 1, 2024

Язык: Английский

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