Causal association of lifestyle factors, clinical features in the risk of sleep disorders: Based on mendelian randomization analysis DOI Creative Commons
Jingyu Xu, Baojuan Wang,

Wenxing Zhu

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Дек. 18, 2024

Abstract Objective: To identify potential genetic risk factors for sleep disorders (SD) and to explore the causal associations between lifestyle clinical features with SD, given limitations of traditional observational studies. Methods: Data from published genome-wide association studies (GWAS) were analyzed, encompassing 34 17 as exposures influencing SD. These analyses yielded information on 51 4 outcomes. Outcomes consisted four categories: non-organic (NSD), narcolepsy, rapid eye movement (REM) behavior (RSBD), obstructive apnea (OSA). All variables exposure outcome derived individuals European ancestry. Two-sample MR analysis was conducted, inverse variance weighted (IVW) primary method evaluating effects. Weighted median estimation (WME), MR-Egger (MRE), simple mode (SM), (WM) used supplementary evaluation methods. Results: (1) The protective causally associated NSD include overall physical activity time (OR: 0.35; 95%CI: 0.13-0.99; P=0.048) fresh fruit intake 0.30; 0.12-0.75; P=0.010). (2) that are related narcolepsy smoking 1.02; 1.01-1.03; P=0.001), alcoholic drinks P=0.013 OR: P<0.001), cereal 1.03; 1.00-1.07; P=0.029), salad/raw vegetable 1.10; 1.03-1.16; P=0.002), TDI 1.05; 1.00-1.10; P=0.036), health rating 1.07; 1.05-1.10; BMI 1.02-1.03; FINS 1.06; 1.03-1.09; P<0.001), TG P<0.001) hypertension 1.08; 1.02-1.15; P=0.011). (3) tea 0.95; 0.93-0.97; non-oily fish 0.91; 0.84-0.99; P=0.021), years schooling 0.97; 0.96-0.99; cognitive performance 0.98; 0.97-0.99; P=0.001), average total household income before tax 0.94; 0.93-0.96; ApoA-I 0.99; 0.99-1.00; HDL 0.98-0.99; P<0.001). (4) OSA 1.20; 1.08-1.34; P=0.001 1.15; 1.06-1.25; alcohol 1.12; 1.01-1.24; P=0.037), coffee 1.25; 1.00-1.56; P=0.046), pork 2.55; 1.37-4.74; P=0.003), 1.56; 1.12-2.19; P=0.009), 2.76; 2.20-3.46; 1.97; 1.85-2.11; WHR 1.30; 1.08-1.55; P=0.004), 1.02-1.11; 2.72; 1.73-4.26; CRP 1.01-1.11; P=0.016). (5) bread 0.63; 0.49-0.83; 0.71; 0.56-0.90; P=0.005), dried 0.64; 0.50-0.83; 0.72; 0.66-0.79; 0.79; 0.71-0.87; 0.78; 0.66-0.93; FPG 0.84; 0.75-0.94; P=0.003), 0.90-0.99; P=0.017) 0.89; 0.85-0.93; (6) After multivariate through adjusting BMI, ApoA-I, TG, still exists. Conclusions: evidence this study suggests among factors: NSD. Smoking drinks, intake, poverty, poor rating, high narcolepsy. Tea non oily education cognition, OSA. Bread Among features: is a factor High FINS, hypertension, FPG, There not enough suggest other relationships meet criteria established.

Язык: Английский

Melatonin modulates TLR4/MyD88/NF-κB signaling pathway to ameliorate cognitive impairment in sleep-deprived rats DOI Creative Commons
Chao Yin, Meiya Zhang, Li Cheng

и другие.

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Июль 19, 2024

Sleep deprivation (SD) is commonplace in today's fast-paced society. SD a severe public health problem globally since it may cause cognitive decline and even neurodegenerative disorders like Alzheimer's disease. Melatonin (MT) natural chemical secreted by the pineal gland with neuroprotective effects. The purpose of this study was to investigate protective effect mechanism MT on chronic sleep deprivation-induced impairment. A 3-week modified multi-platform method used create rat model. Morris water maze test (MWM), Tissue staining (including Hematoxylin Eosin (H & E) staining, Nissl immunofluorescence), Western blot, Enzyme-linked immunosorbent assay (ELISA), Quantitative real-time polymerase chain reaction (qPCR) were ameliorating impairment rats. results showed that (50 100 mg/kg) significantly improved function rats, as evidenced shortening escape latency increased time crossing platform spent quadrant. Additionally, therapy alleviated hippocampus neurodegeneration neuronal loss while lowering levels pathogenic factors (LPS) inflammatory indicators (IL-1β, IL-6, TNF-α, iNOS, COX2). Furthermore, treatment reversed high expression Aβ42 Iba1 well low ZO-1 occludin, inhibited SD-induced TLR4/MyD88/NF-κB signaling pathway. In summary, ameliorated spatial recognition learning memory dysfunction rats reducing neuroinflammation increasing neuroprotection inhibiting Our supports use an alternate for

Язык: Английский

Процитировано

4
Association between sleep quality and MCI in older adult patients with multimorbidity DOI Creative Commons
Ting Yang, Guangping Zheng,

Shuzhi Peng

и другие.

Frontiers in Public Health, Год журнала: 2025, Номер 13

Опубликована: Март 18, 2025

To explore the relationship between sleep quality and mild cognitive impairment in older adult patients with multimorbidity. The general data of chronic diseases were collected, (MCI) multimorbidity investigated by questionnaire. Logistic regression model restricted cubic spline (RCS) used to analyze correlation MCI There are 902 valid samples this study, which 333 (36.9%) have MCI. number ranges from 2 6, types medication 0 7. score PSQI is 2-18, an average 11.13. MoCA range 7-30. lower than that Non-MCI patients. In all three models, significantly correlated results segmented analysis show that: inflection point MCI's scoring 12. RCS result display: increase score, OR increases MCI, when reaches 12, higher 1. Sleep important influencing factor there a threshold effect above association. According correlation, health professionals can take measures improve reduce occurrence

Язык: Английский

Процитировано

0
Gut microbiota: a new target for the prevention and treatment of insomnia using Chinese herbal medicines and their active components DOI Creative Commons

Chenxi Wu,

Jinjin Dou,

Xiaoxue Song

и другие.

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Май 6, 2025

The emergence of the microbiota-gut-brain axis has opened new avenues for improving sleep quality. Recent studies have revealed a close relationship between insomnia and gut microbiome. Chinese herbal medicines their active components can alter relative abundance sleep-related microbiota by reversing dysbiosis in Improving quality through regulation using medicine its become highly promising therapeutic strategy. This article elucidates how modulates via intricate communication network gut-brain axis. It also reviews latest research on utilizing to regulate enhancing Additionally, it provides insights into potential modulation microbiota.

Язык: Английский

Процитировано

0
Sleep deprivation-induced shifts in gut microbiota: Implications for neurological disorders DOI
Nitu L. Wankhede, Mayur B. Kale,

Ashishkumar Kyada

и другие.

Neuroscience, Год журнала: 2024, Номер 565, С. 99 - 116

Опубликована: Ноя. 30, 2024

Язык: Английский

Процитировано

3
Herbal medicines in Alzheimer’s disease and the involvement of gut microbiota DOI Creative Commons
Mingli Liu,

Tuming Li,

Huazheng Liang

и другие.

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Июль 16, 2024

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by memory loss and cognitive impairment. It severely affects the quality of life victims. The prevalence AD has been increasing in recent years. Therefore, it great importance to elucidate pathogenic mechanism search for effective therapeutic approaches. Gut microbiota dysbiosis, an altered state gut microbiota, well known its involvement pathogenesis AD. Much effort made searching approaches capable modulating composition Herbal medicines have attracted extensive attention decades prevention treatment Here, we gave overview research progress on modulatory effects herbal formulae as possible beneficial AD, which may provide new insights into discovery anti-AD agents their potential through microbiota.

Язык: Английский

Процитировано

2
Modifications in the Composition of the Gut Microbiota in Rats Induced by Chronic Sleep Deprivation: Potential Relation to Mental Disorders DOI Creative Commons

Li-Ming Zheng,

Yan Li

Nature and Science of Sleep, Год журнала: 2024, Номер Volume 16, С. 1313 - 1325

Опубликована: Сен. 1, 2024

Sleep deprivation(SD) has numerous negative effects on mental health. A growing body of research confirmed the implication gut microbiota in disorders. However, specific modifications mammalian following SD exhibit variations across different studies.

Язык: Английский

Процитировано

2
The NF-κB Pathway: Key Players in neurocognitive functions and related disorders DOI Creative Commons

Danfeng Yang,

Junwei Su,

Yeru Chen

и другие.

European Journal of Pharmacology, Год журнала: 2024, Номер 984, С. 177038 - 177038

Опубликована: Окт. 5, 2024

Язык: Английский

Процитировано

2
Continuous Theta Burst Stimulation Inhibits Oxidative Stress-Induced Inflammation and Autophagy in Hippocampal Neurons by Activating Glutathione Synthesis Pathway, Improving Cognitive Impairment in Sleep-Deprived Mice DOI
Yi Zhang, Cheng Zhang, Qing Dai

и другие.

NeuroMolecular Medicine, Год журнала: 2024, Номер 26(1)

Опубликована: Окт. 10, 2024

Язык: Английский

Процитировано

2
S100A8 knockdown activates the PI3K/AKT signaling pathway to inhibit microglial autophagy and improve cognitive impairment mediated by chronic sleep deprivation DOI Creative Commons
Yanhong Xiong,

Weidong Liang,

Xifeng Wang

и другие.

International Immunopharmacology, Год журнала: 2024, Номер 143, С. 113375 - 113375

Опубликована: Окт. 16, 2024

Cognitive dysfunction is one of the major symptoms chronic sleep deprivation (CSD). Abnormal autophagy and apoptosis are thought to be important mechanisms. S100 Calcium Binding Protein A8 (S100A8) plays a key role in microglia. This study investigated whether S100A8 knockdown can effectively inhibit aberrant microglia improve cognitive function by activating phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) signaling pathway under CSD conditions.

Язык: Английский

Процитировано

2
Impaired Basal Forebrain Cholinergic Neuron GDNF Signaling Contributes to Perioperative Sleep Deprivation–Induced Chronicity of Postsurgical Pain in Mice Through Regulating Cholinergic Neuronal Activity, Apoptosis, and Autophagy DOI Creative Commons
Dong Wang,

Shi‐Nan Wei,

Lu Zhang

и другие.

CNS Neuroscience & Therapeutics, Год журнала: 2024, Номер 30(12)

Опубликована: Дек. 1, 2024

ABSTRACT Aims This study investigated the roles of lateral basal forebrain glial cell line–derived neurotrophic factor (GDNF) signaling and cholinergic neuron activity, apoptosis, autophagy dysfunction in sleep deprivation–induced increased risk chronic postsurgical pain (CPSP) mice. Methods Sleep deprivation (6 h per day from −1 to 3 days postoperatively) was administered mice receiving skin/muscle incision retraction (SMIR) determine whether perioperative induces mechanical thermal hypersensitivity, increases pain, causes changes neurons activity (c‐Fos immunostaining), apoptosis (cleaved Caspase‐3 expression), (LC3 p62 expression) GDNF expression. Adeno‐associated virus (AAV)‐GDNF microinjected into see expression could reverse duration autophagy. Cholinergic were further depleted by mu p75‐SAP examine pain‐prolonging effects still exist. Results Perioperative enhanced sensation prolonged SMIR mice, which accompanied decreased expression, substantia innominata (SI), magnocellular preoptic nucleus (MCPO), horizontal diagonal band Broca (HDB) (hereafter forebrain). Normalizing AAV‐GDNF inhibited mitigated maintenance. Mice with selective lesion resistant pain‐enhancing prolonging pain‐alleviating therapy. Conclusions promotes chronicity possibly through decreasing causing neuronal dysfunction.

Язык: Английский

Процитировано

2