Design and Synthesis of Novel 3β-O-Succinyl-lupeol and 3β-O-Maleicyl-lupeol Derivatives as Potential Antitumor Agents DOI
Zhuo Chen, Tianhong Xu, Ran Luo

и другие.

Russian Journal of General Chemistry, Год журнала: 2024, Номер 94(11), С. 2972 - 2983

Опубликована: Ноя. 1, 2024

Язык: Английский

Utilizing UHPLC-HRMS-metabolomic profiling to uncover enhanced bioactive potential and health benefits in chili (Capsicum annum L.) under salinity stress DOI

Amantika Singh,

Krishna Kumar Choudhary

Food Chemistry, Год журнала: 2025, Номер unknown, С. 144255 - 144255

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
A new ceramide and other constituents from Crinum ornatum (L.f.) Herb. (Amaryllidaceae) and their chemophenetic significance DOI

Kedeu Kouvourbe,

Christine Claire Waleguele,

Yves Martial Mba Nguekeu

и другие.

Biochemical Systematics and Ecology, Год журнала: 2025, Номер 121, С. 104991 - 104991

Опубликована: Март 3, 2025

Язык: Английский

Процитировано

0
A Terpenoid-Rich Fraction of <em>Inula viscosa</em>: Its Chemical Composition, Antioxidant Capacity, and Anticancerous Effects Against Human Lung Cancer Cells DOI Open Access
Fatiha Seglab,

Mazen Abou Assali,

Thoraya AlYafei

и другие.

Опубликована: Июль 10, 2024

Inula viscosa is a widely used plant in traditional Mediterranean and Middle Eastern medicine for various illnesses. I. has been shown to have anticancerous effects against cancers, but its lung cancer under limited investigation. At the same time, rich terpenoids whose anti-lung poorly investigated. This study aimed examine potential properties of methanolic aqueous extracts stems leaves terpenoid-rich fraction human A549 cells. Results showed high radical scavenging capacity polyphenol flavonoid contents rather than extracts. In addition, (IVLM) highest reduction viability cells among all IVLM also reduced ovarian SK-OV-3, breast MCF-7, liver HepG2, colorectal HCT116 A (IVL DCM), prepared by liquid-liquid separation dichloromethane (DCM), displayed substantial (IC50= 27.8 &plusmn; 1.5 &micro;g/mL at 48 h) panel tested cancerous cell lines was not cytotoxic normal embryonic fibroblasts (HDFn). The assessment IVL DCM phytochemical constituents using GC-MS analysis revealed 21 metabolites, highlighting an enrichment terpenoids, such as lupeol derivatives, caryophyllene oxide, betulin, isopulegol, known exhibit proapoptotic, antimetastatic functions. robust antioxidant decent contents. Furthermore, Western blotting indicated that proliferation (reduction marker Ki67 induction inhibitor proteins P21 P27), contaminant with P38 MAP kinase activation, induced intrinsic apoptotic pathway (P53/BCL2/BAX/ Caspase3/PARP) migration cells, potentially reducing FAK activation. Future identification anticancer metabolites DCM, especially recommended. These data place new resource herbal agents.

Язык: Английский

Процитировано

1
Thiazolidinedione-Conjugated Lupeol Derivatives as Potent Anticancer Agents Through a Mitochondria-Mediated Apoptotic Pathway DOI Creative Commons

Siqi Deng,

Yinxu Zhao,

Xiaoshan Guo

и другие.

Molecules, Год журнала: 2024, Номер 29(20), С. 4957 - 4957

Опубликована: Окт. 20, 2024

To improve the potential of lupeol against cancer cells, a privileged structure, thiazolidinedione, was introduced into its C-3 hydroxy group with ester, piperazine-carbamate, or ethylenediamine as linker, and three series thiazolidinedione-conjugated compounds (

Язык: Английский

Процитировано

1
Chemical Composition, Antioxidant Capacity, and Anticancerous Effects against Human Lung Cancer Cells of a Terpenoid-Rich Fraction of Inula viscosa DOI Creative Commons
Fatiha Seglab,

Mazen Abou Assali,

Thoraya AlYafei

и другие.

Biology, Год журнала: 2024, Номер 13(9), С. 687 - 687

Опубликована: Сен. 2, 2024

Inula viscosa is a widely used plant in traditional Mediterranean and Middle Eastern medicine for various illnesses. I. has been shown to have anticancer effects against cancers, but its lung cancer under limited investigation. At the same time, rich terpenoids whose anti-lung poorly investigated. This study aimed examine potential properties of methanolic aqueous extracts stems leaves terpenoid-rich fraction human A549 cells. Results showed that had significantly higher polyphenol flavonoid content radical scavenging capacity than extracts. In addition, (IVLM) caused highest reduction viability cells among all IVLM also reduced ovarian SK-OV-3, breast MCF-7, liver HepG2, colorectal HCT116 A (IVL DCM), prepared by liquid-liquid separation dichloromethane (DCM), displayed substantial (IC50 = 27.8 ± 1.5 µg/mL at 48 h) panel tested cancerous cell lines was not cytotoxic normal embryonic fibroblasts (HDFn). The assessment IVL DCM phytochemical constituents using GC-MS analysis revealed 21 metabolites, highlighting an enrichment terpenoids, such as lupeol derivatives, caryophyllene oxide, betulin, isopulegol, known exhibit proapoptotic antimetastatic functions. robust antioxidant decent contents. Furthermore, Western blotting indicated proliferation (reduction marker Ki67 induction inhibitor proteins P21 P27), contaminant with P38 MAP kinase activation, induced intrinsic apoptotic pathway (P53/BCL2/BAX/Caspase3/PARP) migration cells, potentially reducing FAK activation. Future identification metabolites DCM, especially recommended. These data place new resource herbal agents.

Язык: Английский

Процитировано

0
Design, Synthesis, and Antitumor Activity Evaluation of Novel Lupeol-3-urea/thiourea Derivatives DOI
Tianhong Xu, Ran Luo, Zhuo Chen

и другие.

Russian Journal of General Chemistry, Год журнала: 2024, Номер 94(10), С. 2759 - 2769

Опубликована: Окт. 1, 2024

Язык: Английский

Процитировано

0
Design and Synthesis of Novel 3β-O-Succinyl-lupeol and 3β-O-Maleicyl-lupeol Derivatives as Potential Antitumor Agents DOI
Zhuo Chen, Tianhong Xu, Ran Luo

и другие.

Russian Journal of General Chemistry, Год журнала: 2024, Номер 94(11), С. 2972 - 2983

Опубликована: Ноя. 1, 2024

Язык: Английский

Процитировано

0