Targeting CD4+ T cells through gut microbiota: therapeutic potential of traditional Chinese medicine in inflammatory bowel disease

Frontiers in Cellular and Infection Microbiology, Год журнала: 2025, Номер 15

Опубликована: Март 3, 2025

Inflammatory Bowel Disease (IBD) is an autoimmune disease characterized by chronic relapsing inflammation of the intestinal tract. Gut microbiota (GM) and CD4 + T cells are important in development IBD. A lot studies have shown that GM their metabolites like short-chain fatty acids, bile acids tryptophan can be involved differentiation through various mechanisms, which turn regulate immune homeostasis IBD patients. Therefore, regulating may a potential therapeutic direction for treatment Many Traditional Chinese Medicine (TCM) formulas some herbal extracts affect cell its metabolites. In this review, we mainly focus on role correlation with We also summarize current research progress regulation process TCM.

Язык: Английский

Combination of Youhua Kuijie Prescription and sulfasalazine can alleviate experimental colitis via IL-6/JAK2/STAT3 pathway

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Сен. 10, 2024

Youhua Kuijie prescription (YHKJ) is a hospital preparation that composed of nine kinds herbs. Sulfasalazine (SASP) widely used as first-line clinical treatment for UC. Traditional Chinese medicine and Western have their own advantages in the UC, mechanism YHKJ combined with SASP UC needs to be investigated.

Язык: Английский

Network Pharmacology to Reveal the Mechanism of Fufang Banmao Capsule for Treating Unresectable Primary Liver Cancer and Clinical Data Validation

Current Pharmaceutical Design, Год журнала: 2024, Номер 30(35), С. 2785 - 2796

Опубликована: Авг. 2, 2024

Fufang Banmao capsule (FFBM), a traditional Chinese medicine, has been used to treat primary liver cancer (PLC) for several years. However, the bioactive ingredients, and mechanism of FFBM treating PLC remains unclear. Our objective is utilize network pharmacology investigate these aspects subsequently validate their effectiveness through clinical data.

Язык: Английский