Calcium signaling hypothesis: A non-negligible pathogenesis in Alzheimer’s disease

Journal of Advanced Research, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Alzheimer's disease (AD) presents a significant challenge to global healthcare systems, with an exacerbation by aging population. Although the plethora of hypotheses are proposed elucidate underlying mechanisms AD, from amyloid-beta (Aβ) accumulation and Tau protein aggregation neuroinflammation, comprehensive understanding its pathogenesis remains elusive. Recent research has highlighted critical role calcium (Ca This review aims consolidate current Ca The focuses on three principal concepts. First, indispensable

Язык: Английский

---

Exploring the Mechanism by Which Zexie Tang Regulates Alzheimer's Disease: Insights from Multi-Omics Analysis

Phytomedicine, Год журнала: 2025, Номер 139, С. 156453 - 156453

Опубликована: Фев. 7, 2025

Язык: Английский

---

Chronic Inflammation Linking Atherosclerosis to Cognitive Impairment: Multi-Target Mechanisms and Therapeutic Advances in Chinese Herbal Medicine

Brain Behavior and Immunity Integrative, Год журнала: 2025, Номер unknown, С. 100122 - 100122

Опубликована: Апрель 1, 2025

Язык: Английский

---

Tricetin, a Dietary Flavonoid, Alleviates Neuroinflammation and Promotes Autophagy in Alzheimer’s Disease by Regulating the PI3K/Akt/mTOR Signaling Pathway

Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 14, 2025

Alzheimer's disease (AD), the most prevalent neurodegenerative disorder among older adults, significantly impairs behavioral and cognitive functions, posing a severe threat to patients' health quality of life. The Tricetin (TRN), natural flavonoid found in wheat, pomegranate, eucalyptus honey, has demonstrated anti-inflammatory, antitumor, neuroprotective properties. However, its role context AD not been previously explored. This study investigated antineuroinflammatory autophagic protective effects TRN lipopolysaccharide (LPS)-induced BV2 cells D-galactose/sodium nitrite/aluminum chloride (D-gal/NaNO2/AlCl3)-induced mice. RNA sequencing examined underlying mechanisms by which ameliorates AD-related pathologies. Our research findings revealed that improved memory mobility mice, reduced Aβ deposition, inhibited Tau protein phosphorylation. Furthermore, regulated enzyme activities pathological markers associated with AD. Moreover, it modulated inflammatory mediators, nuclear translocation NF-κB LPS-induced cells, exerted anti-inflammatory via PI3K/Akt/mTOR signaling pathway. In conclusion, robust vitro vivo models regulating These highlight potential as promising therapeutic agent for treating

Язык: Английский

---

miR-124 mediates the effects of gut microbial dysbiosis on brain function in chronic stressed mice

Behavioural Brain Research, Год журнала: 2024, Номер 476, С. 115262 - 115262

Опубликована: Сен. 19, 2024

Язык: Английский

---