Dysregulation of Mitochondrial in Pulmonary Hypertension-Related Right Ventricular Remodeling: Pathophysiological Features and Targeting Drugs DOI Creative Commons
Yuehan Wang,

Yingzhuo Wang,

Weifang Zhang

и другие.

Reviews in Cardiovascular Medicine, Год журнала: 2025, Номер 26(3)

Опубликована: Март 18, 2025

Pulmonary hypertension (PH) is a life-threatening condition characterized by right ventricular (RV) remodeling, which major determinant of patient survival. The progression remodeling significantly influenced mitochondrial dysfunction, providing profound insights into vascular health and cardiovascular risk. In this review, we discuss the molecular targets, pathophysiological characteristics, potential mechanisms underlying dysfunction in PH, encompassing disturbances dynamics, inflammation, dysregulation energy metabolism. Finally, review primary therapeutic targets currently utilized to address cardiac resulting from damage. Hopefully, might inspire novel approaches management disorders.

Язык: Английский

Tianlong Kechuanling Decoction Attenuates Pulmonary Hypertension by Inhibiting Endothelial-to-Mesenchymal Transition DOI

Jing Gong,

Huihua Li, Xu Cui

и другие.

Journal of Ethnopharmacology, Год журнала: 2025, Номер unknown, С. 119395 - 119395

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
Ferroptosis in organ fibrosis: Mechanisms and therapeutic approaches DOI

Zhi-Hong Ning,

Xiuheng Wang, Yue Zhao

и другие.

International Immunopharmacology, Год журнала: 2025, Номер 151, С. 114341 - 114341

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Dysregulation of Mitochondrial in Pulmonary Hypertension-Related Right Ventricular Remodeling: Pathophysiological Features and Targeting Drugs DOI Creative Commons
Yuehan Wang,

Yingzhuo Wang,

Weifang Zhang

и другие.

Reviews in Cardiovascular Medicine, Год журнала: 2025, Номер 26(3)

Опубликована: Март 18, 2025

Pulmonary hypertension (PH) is a life-threatening condition characterized by right ventricular (RV) remodeling, which major determinant of patient survival. The progression remodeling significantly influenced mitochondrial dysfunction, providing profound insights into vascular health and cardiovascular risk. In this review, we discuss the molecular targets, pathophysiological characteristics, potential mechanisms underlying dysfunction in PH, encompassing disturbances dynamics, inflammation, dysregulation energy metabolism. Finally, review primary therapeutic targets currently utilized to address cardiac resulting from damage. Hopefully, might inspire novel approaches management disorders.

Язык: Английский

Процитировано

0