Metasilicate-based alkaline mineral water improves the growth performance of weaned piglets by maintaining gut-liver axis homeostasis through microbiota-mediated secondary bile acid pathway DOI Creative Commons
Jian Chen, Kanwar Kumar Malhi, Xiaowei Li

и другие.

Animal nutrition, Год журнала: 2024, Номер 20, С. 95 - 109

Опубликована: Ноя. 2, 2024

Weaning stress causes substantial economic loss in the swine industry. Moreover, weaning-induced intestinal barrier damage and dysfunction of gut-liver axis are associated with reduced growth performance piglets. Metasilicate-based alkaline mineral water (AMW) has shown potential therapeutic effects on gastrointestinal disorders; however, mechanisms involved their overall have not been explored. Here, sodium metasilicate (SMS) was used to prepare metasilicate-based AMW (basal + 500 mg/L SMS). A total 240 newly weaned piglets were allocated Control SMS groups (6 replicate pens per group 20 pen) for a 15-day trial period. Histopathological evaluations conducted using hematoxylin eosin staining. To analyze composition gut microbiota, 16S rRNA PacBio SMRT Gene Full-Length Sequencing performed. Western blotting immunofluorescence employed assess protein expression levels. Our results indicated that effectively alleviated colonic or liver morphological injury inflammatory response, as well cholesterol metabolism disorders. Further analysis showed promoted deoxycholic acid (DCA) biosynthesis by increasing abundance Lactobacillus_delbrueckii colon (P < 0.001). This consequently improved through DCA-secondary bile (SBA) receptors (SBAR)-nuclear factor-kappaB (NF-κB)/NOD-like receptor family pyrin domain-containing 3 (NLRP3) pathways. Growth parameters, including final body weight = 0.034) average daily gain 0.001), significantly higher than those group. Therefore, maintains homeostasis regulating microbiota-mediated SBA-SBAR pathway under weaning stress. research provides new strategy mitigating stress-induced

Язык: Английский

Unraveling the AMPK-SIRT1-FOXO Pathway: The In-Depth Analysis and Breakthrough Prospects of Oxidative Stress-Induced Diseases DOI Creative Commons
Guoqiang Guan, Yaoxing Chen, Yulan Dong

и другие.

Antioxidants, Год журнала: 2025, Номер 14(1), С. 70 - 70

Опубликована: Янв. 9, 2025

Oxidative stress (OS) refers to the production of a substantial amount reactive oxygen species (ROS), leading cellular and organ damage. This imbalance between oxidant antioxidant activity contributes various diseases, including cancer, cardiovascular disease, diabetes, neurodegenerative conditions. The body’s system, mediated by signaling pathways, includes AMPK-SIRT1-FOXO pathway. In oxidative conditions, AMPK, an energy sensor, activates SIRT1, which in turn stimulates FOXO transcription factor. cascade enhances mitochondrial function, reduces damage, mitigates OS-induced injury. review provides comprehensive analysis biological roles, regulatory mechanisms, functions pathway diseases influenced OS, offering new insights methods for understanding OS pathogenesis its therapeutic approaches.

Язык: Английский

Процитировано

1
Lycopene, a natural plant extract, alleviates atrazine-induced ferroptosis in hepatocytes by activating cytochrome P450 oxidoreductase DOI
Ping-An Jian,

Tian‐Ning Yang,

Yuxiang Wang

и другие.

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 142311 - 142311

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Metasilicate-based alkaline mineral water improves the growth performance of weaned piglets by maintaining gut-liver axis homeostasis through microbiota-mediated secondary bile acid pathway DOI Creative Commons
Jian Chen, Kanwar Kumar Malhi, Xiaowei Li

и другие.

Animal nutrition, Год журнала: 2024, Номер 20, С. 95 - 109

Опубликована: Ноя. 2, 2024

Weaning stress causes substantial economic loss in the swine industry. Moreover, weaning-induced intestinal barrier damage and dysfunction of gut-liver axis are associated with reduced growth performance piglets. Metasilicate-based alkaline mineral water (AMW) has shown potential therapeutic effects on gastrointestinal disorders; however, mechanisms involved their overall have not been explored. Here, sodium metasilicate (SMS) was used to prepare metasilicate-based AMW (basal + 500 mg/L SMS). A total 240 newly weaned piglets were allocated Control SMS groups (6 replicate pens per group 20 pen) for a 15-day trial period. Histopathological evaluations conducted using hematoxylin eosin staining. To analyze composition gut microbiota, 16S rRNA PacBio SMRT Gene Full-Length Sequencing performed. Western blotting immunofluorescence employed assess protein expression levels. Our results indicated that effectively alleviated colonic or liver morphological injury inflammatory response, as well cholesterol metabolism disorders. Further analysis showed promoted deoxycholic acid (DCA) biosynthesis by increasing abundance Lactobacillus_delbrueckii colon (P < 0.001). This consequently improved through DCA-secondary bile (SBA) receptors (SBAR)-nuclear factor-kappaB (NF-κB)/NOD-like receptor family pyrin domain-containing 3 (NLRP3) pathways. Growth parameters, including final body weight = 0.034) average daily gain 0.001), significantly higher than those group. Therefore, maintains homeostasis regulating microbiota-mediated SBA-SBAR pathway under weaning stress. research provides new strategy mitigating stress-induced

Язык: Английский

Процитировано

0