Harnessing the immunomodulatory potential of natural products in precision medicine—a comprehensive review

Опубликована: Июнь 27, 2024

Traditional medicine systems worldwide utilize natural products (NPs), including plant-derived compounds, minerals, and organisms, harnessing their healing potential. NPs offer a rich source of potential drug candidates, driving innovation in discovery. Recent breakthroughs have reignited interest the therapeutic benefits compounds. Clinical applications NP-based immunotherapies, such as curcumin resveratrol cancer treatment, highlight diverse pharmacological properties. However, despite these advancements, challenges persist clinical implementation NPs. Issues standardization, regulatory approval, supply sustainability remain significant hurdles. Overcoming limitations requires concerted effort to address complexities NP development. Nevertheless, ongoing research efforts interdisciplinary collaboration hold promise for advancing therapeutics, paving way development innovative treatments various diseases. In world precision medicine, new chapter unfolds join journey. The exploration sources bioactive compounds has revealed promising prospects therapeutics medicine. This article explores within context It examines intricate pathways through which derived from nature tailored prospects, emphasizing role interventions. Exploring synergy between at molecular level, this delineates exciting prospect customized treatments, signifying transformative impact on modern medical care. review further highlights tailoring based individual genetic makeup disease characteristics. Additionally, it discusses addressing issues sourcing, scalability, considerations realize full

Язык: Английский

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Physicochemical properties, structure, growth-promoting and antioxidant activities of Glycyrrhiza leaf polysaccharides modified by fermentation

Chemical and Biological Technologies in Agriculture, Год журнала: 2025, Номер 12(1)

Опубликована: Янв. 14, 2025

This study aimed to investigate the effects of fermentation on physicochemical properties and in vitro antioxidant activities Glycyrrhiza leaf, compare structures unfermented (GLP) fermented (FGLP) polysaccharides, assess their growth-promoting using zebrafish embryos. The results showed that polysaccharide content, extract yield, reduced sugar content leaf increased significantly after 36 h fermentation. In parallel, assays demonstrated for exhibited strong DPPH, hydroxyl radical scavenging, reducing power. Scanning electron microscope infrared spectroscopy analyses revealed differences surface morphology with both polysaccharides being acidic containing pyranose rings α-glycosidic bonds. molecular weight FGLP was lower than GLP, molar ratios guluronic acid, amino glucose, glucuronic xylose, arabinose were increased. model, promoted growth development embryos, most pronounced effect at a concentration 20 µg/mL superior protective against lipid peroxidation cell death induced by 2,2′-azobis (2-methylpropionamidine) dihydrochloride. findings could enhance utilization capacity. These opened avenues further research into bioavailability vivo offered valuable insights its potential as natural innovative antioxidant. Highlights

Язык: Английский

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Ancient Wisdom of <i>Ayurveda</i>: The Anti-inflammatory Benefits of Herbs for Managing Mastitis in Dairy Animals in South Asia

Journal of Natural Remedies, Год журнала: 2025, Номер unknown, С. 257 - 277

Опубликована: Фев. 28, 2025

Mastitis, characterized by mammary gland inflammation due to microorganisms, significantly reduces dairy animal productivity up 70%. Clinical mastitis prevalence stands at 11%, with sub-clinical cases a staggering 77%, highlighting its substantial impact on milk yield. Given the escalating concern of antibiotic resistance, exploring alternative therapies for treatment, particularly herbal remedies from Ayurveda and Ethno-veterinary practices, is imperative. Literature herbs used in bovine within South Asian countries was meticulously gathered diverse sources, including books electronic databases like Web Science, PubMed, ScienceDirect, Google Scholar domestic literature. A comprehensive review identified 83 documented anti-inflammatory properties, assessing their potential treating animals. Constituents such as flavonoids, polyphenols, terpenoids, alkaloids, vitamins, minerals were scrutinised effects. Additionally, formulations mentioned ancient Indian veterinary Sanskrit manuscript ‘Ashvavaidyakam’ have been revealed verify ability mitigate associated future. This synthesizes traditional wisdom contemporary scientific evidence advocate further research dialogue. It underscores develop effective sustainable control strategies practices. Plant-based are highlighted reduce production losses costs, thereby proving therapeutic significance farmers. The integration knowledge modern findings presents promising avenues addressing Embracing offers not only economic benefits but also contributes sustainability farming practices Asia. Further this area crucial harness full management. Major Findings: total properties treatment. Active constituents terpenoids alkaloids exhibit significant potential. Herbal Ashvavaidyakam offer leads management

Язык: Английский

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DIORS: Enhancing drug-target interaction prediction via structure and signature integrated-driven approach and discovering potential targeted molecules

Pharmacological Research, Год журнала: 2025, Номер unknown, С. 107710 - 107710

Опубликована: Март 1, 2025

Drug-target interaction prediction is critical for drug development. Through the integration of structural and transcriptional signature information, molecules both binding to target inducing therapeutic activities could be found out improve targeted prediction. Therefore, approaches that integrate two types data are worth exploring. Here, we present an integrated method named Data Integration Oriented Repurposing Strategy (DIORS) combining molecular docking gene-signature matching enhance protein-targeted drugs. The StandardScaler algorithm was selected after evaluation five algorithms used in DIORS. Surface Plasmon Resonance (SPR) verify affinities cell-based assays were DIORS predicted molecules. In Piezo1-targeted molecule prediction, among top ten by DIORS, four them, namely gefitinib, rifaximin, bosutinib vandetanib, exhibited affinities. TLR4/MD2-targeted anti-inflammatory molecules, three enoxolone, dabrafenib ponatinib, exhibit high activities. results demonstrated can serve as a better approach with performance predict find new drugs information.

Язык: Английский

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Growth performance and nutrient use efficiency of hydroponically grown licorice ( Glycyrrhiza glabra L.) under different calcium and magnesium concentrations

Journal of Plant Nutrition, Год журнала: 2025, Номер unknown, С. 1 - 18

Опубликована: Май 20, 2025

Язык: Английский

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Development and characterization of natural sourced bioplastic synthesized from tamarind seeds, berry seeds and licorice root

Applied Surface Science Advances, Год журнала: 2022, Номер 11, С. 100313 - 100313

Опубликована: Окт. 1, 2022

The use of fossil fuel-based plastics is harmful for our natural environment. Moreover, these are single used plastics, difficult to recycle and non-biodegradable. These polluting environment affecting marine organisms. Attention being paid search an alternative source replace plastics. Biodegradable renewable can be such This study tamarind seeds, berry licorice root manufacture bioplastic materials. have been characterize the manufactured materials by biodegradation, tensile, Fourier Transformed Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), Thermogravimetric Analysis (TGA), Differential Calorimetry (DSC) antimicrobial analysis. Satisfactory results obtained from characterization reports. Bioplastic without presence showed better biodegradable, mechanical, thermal antibacterial properties. as food packaging according obtained.

Язык: Английский

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A comprehensive review on angel's trumpet (Brugmansia suaveolens)

South African Journal of Botany, Год журнала: 2022, Номер 151, С. 266 - 274

Опубликована: Фев. 23, 2022

Язык: Английский

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Licochalcone A: A Potential Multitarget Drug for Alzheimer’s Disease Treatment

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(18), С. 14177 - 14177

Опубликована: Сен. 16, 2023

Licochalcone A (Lico-A) is a flavonoid compound derived from the root of Glycyrrhiza species, plant commonly used in traditional Chinese medicine. While species has shown promise treating various diseases such as cancer, obesity, and skin due to its active compounds, investigation A’s effects on central nervous system potential application Alzheimer’s disease (AD) treatment have garnered significant interest. Studies reported neuroprotective Lico-A, suggesting multitarget compound. Lico-A acts PTP1B inhibitor, enhancing cognitive activity through BDNF-TrkB pathway exhibiting inhibitory microglia activation, which enables mitigation neuroinflammation. Moreover, inhibits c-Jun N-terminal kinase 1, key enzyme involved tau phosphorylation, modulates brain insulin receptor, plays role processes. also an acetylcholinesterase leading increased levels neurotransmitter acetylcholine (Ach) brain. This mechanism enhances capacity individuals with AD. Finally, ability reduce amyloid plaques, hallmark AD, exhibits antioxidant properties by activating nuclear factor erythroid 2-related 2 (Nrf2), regulator defense mechanisms. In present review, we discuss available findings analyzing agent. Continued research holds for development novel treatments disorders neurodegenerative diseases, including Further investigations into action elucidation underlying mechanisms will contribute our understanding therapeutic potential.

Язык: Английский

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Nanofibers of Glycyrrhizin/Hydroxypropyl-β-Cyclodextrin Inclusion Complex: Enhanced Solubility Profile and Anti-inflammatory Effect of Glycyrrhizin

AAPS PharmSciTech, Год журнала: 2023, Номер 24(7)

Опубликована: Окт. 2, 2023

Язык: Английский

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Accelerating healing of infected wounds with G. glabra extract and curcumin Co-loaded electrospun nanofibrous dressing

Journal of Biomaterials Applications, Год журнала: 2024, Номер 39(3), С. 249 - 265

Опубликована: Июнь 5, 2024

This study aimed to construct a nanofibrous wound dressing composed of polyvinyl alcohol (PVA) and chitosan (CS) containing curcumin Glycyrrhiza glabra root extract inhibit infection accelerate healing. Loading 10 wt% G. extract-curcumin (50:50) by electrospinng technique resulted in the formation nanofibers (NFs) with diameter distribution 303 ± 38 had uniform defect-free morphology. FTIR analysis confirmed loading components without adverse interactions. Also, results showed extremely high porosity, extraordinary liquid absorption capacity, complete wettability. In addition, significant antioxidant activity their release profile from NFs was continuous sustained. prepared NF could growth both Gram-positive Saureus Gram-negative E. coli strains. Wound healing evaluation infected animal model that caused full closure accelerated skin regeneration. The studies on inhibiting bacteria at site also revealed inhibitory effects. Moreover, histopathology regeneration layers, collagen fibers, angiogenesis. Finally, PVA/CS as multifunctional bioactive presented promising approach for promoting wounds.

Язык: Английский

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