Archiv der Pharmazie,
Год журнала:
2024,
Номер
unknown
Опубликована: Май 9, 2024
Abstract
As
the
main
active
compound
of
Glycyrrhiza
glabra
L.,
glabridin
(GLD)
has
been
shown
to
have
multiple
bioactivities,
whereas
clinical
application
GLD
is
restricted
by
its
low
water
solubility.
In
this
study,
was
encapsulated
into
a
sulfobutylether‐β‐cyclodextrin
(SBE‐β‐CD)‐based
inclusion
complex
(SBE‐β‐CD/GLD)
freeze‐drying
method.
The
materials
characterization,
antibacterial
activity,
stimulated
cellular
behavior
and
in
vivo
full‐thickness
diabetic
wound
healing
ability
hydrogels
were
assessed
analyzed.
successful
encapsulation
confirmed
ultraviolet
(UV)
visible
spectroscopy,
Fourier
transform
infrared
(FT‐IR),
X‐ray
diffractometer
(XRD),
scanning
electron
microscope
(SEM),
nuclear
magnetic
resonance
(NMR).
SBE‐β‐CD
as
an
excipient
significantly
enhances
solubility
GLD,
SBE‐β‐CD/GLD
showed
excellent
biocompatibility
on
human
vascular
endothelial
cells
(HUVECs)
erythrocytes.
exerted
pronounced
activity
Staphylococcus
aureus
Escherichia
coli
vitro.
markedly
enhanced
antioxidant
compared
with
free
GLD.
potently
accelerates
skin
defects
inhibiting
inflammation.
outcomes
suggest
that
could
be
used
promising
drug
delivery
system
for
Phytotherapy Research,
Год журнала:
2024,
Номер
38(9), С. 4614 - 4627
Опубликована: Июль 30, 2024
Licorice
(Glycyrrhiza
spp.)
has
been
a
cornerstone
of
traditional
Chinese
and
Japanese
medicine.
This
systematic
review
meta-analysis
aimed
to
evaluate
the
efficacy
licorice
formulations,
alone
or
in
combination
with
other
herbs,
on
liver
function
enzymes
patients
primary
disease.
We
systematically
searched
MEDLINE,
Embase,
Scopus,
Web
Science,
Cochrane
Library
up
April
2024.
Randomized
controlled
trials
(RCTs)
comparing
effects
Glycyrrhiza
spp.
preparations
versus
placebo
standard
care
controls
were
included.
Standard
methods
used
extract
data
appraise
eligible
studies.
A
total
15
RCTs,
involving
1367
participants,
included
analysis.
The
studies
varied
widely
geographical
location,
duration,
used.
significantly
reduced
alanine
aminotransferase
(ALT)
by
15.63
U/L
(95%
CI:
-25.08,
-6.18;
p
=
0.001)
aspartate
(AST)
7.37
-13.13,
-1.61;
0.01)
compared
control
groups.
Subgroup
analyses
revealed
that
purified
glycyrrhizic
acid
compounds
particularly
effective,
showing
greater
reductions
ALT
AST
without
significant
heterogeneity.
Although
treatment
did
not
impact
gamma-glutamyl
transferase
bilirubin
(TBIL)
levels
overall,
specific
licorice-herb
show
notable
reduction
TBIL.
safety
profile
was
consistent
known
side
effects,
predominantly
mild
related
its
mineralocorticoid
effects.
Despite
heterogeneity
potential
language
bias,
findings
suggest
can
enhance
function.
Further
should
standardize
explore
role
multifaceted
herbal
formulations
better
understand
hepatoprotective
mechanisms.
A
high-quality
genome
assembly
is
imperative
to
explore
the
evolutionary
basis
of
characteristic
attributes
that
define
chemotype
and
provide
essential
resources
for
a
molecular
breeding
strategy
enhanced
production
medicinal
metabolites.
Here,
using
single-molecule
high-fidelity
(HiFi)
sequencing
reads,
we
report
chromosome-scale
Chinese
licorice
(Glycyrrhiza
uralensis),
widely
used
herbal
natural
medicine.
The
entire
was
achieved
in
eight
chromosomes,
with
contig
scaffold
N50
as
36.02
60.2
Mb,
respectively.
With
only
17
gaps
half
chromosomes
having
no
or
one
gap,
presented
among
best
plant
genomes
date.
Our
results
showed
an
advantage
highly
accurate
long-read
HiFi
data
assembling
heterozygous
including
its
complexed
repeat
content.
Additionally,
our
analysis
revealed
G.
uralensis
experienced
recent
whole-genome
duplication
at
approximately
59.02
million
years
ago
post
gamma
(γ)
triplication
event,
which
contributed
present
features.
metabolic
gene
cluster
identified
355
clusters,
included
biosynthesis
pathway
glycyrrhizin.
annotations
resource
improvement
through
discovery
valuable
genes
engineering
bioactive
components
understanding
evolution
specialized
metabolites
biosynthesis.
Traditional & Kampo Medicine,
Год журнала:
2023,
Номер
10(3), С. 224 - 252
Опубликована: Окт. 7, 2023
Abstract
Background
The
source
of
ninjin'yoeito
(NYT)
is
considered
the
‘Formulary
Bureau
Taiping
People's
Welfare
Pharmacy’,
written
around
1241–52
AD.
NYT
used
to
treat
patients
with
chronic
fatigue,
malaise
qi
deficiency,
and
exhaustion
all
five
parenchymatous
viscera
difficulty
in
recovering.
Key
Findings
formula
consists
12
crude
drugs.
extract
for
medical
use
covered
by
National
Health
Insurance
system
Japan
convalescence
after
recovery
from
diseases,
fatigue
malaise,
anorexia,
perspiration
during
sleep,
cold
limbs,
anemia.
Studies
have
shown
clinical
effects
NYT:
treatment
anemia,
cancer
support,
frailty,
cognitive
dysfunction,
apathy,
fatigue/malaise,
lung
diseases.
Preclinical
studies
support
studies;
activating
ghrelin‐neuropeptide
Y
pathway‐mediated
appetite‐enhancing
effects,
inhibiting
muscle
volume
loss
through
Akt/mTOR
hyperphosphorylation
4E‐BP1
FoxO1‐mediated
Atrogin‐1,
suppressing
hypothalamic–pituitary–adrenal
axis
downregulating
sympathetic‐adrenal‐medullary
GABA
neurons
improving
sociability,
promoting
skeletal
atrophy
activation
PGC‐1α,
hematopoiesis‐promoting
increasing
number
immune
cells
immunocompromised
models.
incidence
adverse
events
was
reported
as
3.09
or
2.03%.
most
significant
are
gastrointestinal
disorders.
Conclusion
Recently,
has
been
widely
several
symptoms
conditions
under
System
Japan.
Clinical
showed
efficacy
well
long‐term
support.
pharmacological
mechanisms
supporting
its
also
being
reported.
Plant Science Today,
Год журнала:
2024,
Номер
unknown
Опубликована: Апрель 1, 2024
Cassia
angustifolia
Vahl.
is
a
medicinal
plant
known
for
its
efficacy
in
treating
various,
including
respiratory
conditions
and
skin
inflammation.
It
possesses
antibacterial
anticancer
properties.
This
work
investigated
the
immunomodulatory
anti-inflammatory
effects
of
C.
angustifolia.
The
ethanol
leaf
extract
was
utilized
to
examine
gene
expression
related
angiogenesis
cytokines
RAW
264.7
macrophage
cells.
results
demonstrated
significant
increase
viability
treated
cells,
accompanied
by
an
improvement
dose-dependent
inhibition
nitric
oxide
production.
GC-MS
analysis
identified
11
active
components
within
extract,
each
exhibiting
distinct
biological
activities
such
as
antioxidant,
antitumor
effects.
Notable
compounds
include
hexadecanoic
acid,
2-pentadecanone,
phthalic
oxalic
carbonic
tricosane,
undecanal
many
others.
In
conclusion,
exhibits
inhibiting
production
enhancing
cytokines.
Archiv der Pharmazie,
Год журнала:
2024,
Номер
unknown
Опубликована: Май 9, 2024
Abstract
As
the
main
active
compound
of
Glycyrrhiza
glabra
L.,
glabridin
(GLD)
has
been
shown
to
have
multiple
bioactivities,
whereas
clinical
application
GLD
is
restricted
by
its
low
water
solubility.
In
this
study,
was
encapsulated
into
a
sulfobutylether‐β‐cyclodextrin
(SBE‐β‐CD)‐based
inclusion
complex
(SBE‐β‐CD/GLD)
freeze‐drying
method.
The
materials
characterization,
antibacterial
activity,
stimulated
cellular
behavior
and
in
vivo
full‐thickness
diabetic
wound
healing
ability
hydrogels
were
assessed
analyzed.
successful
encapsulation
confirmed
ultraviolet
(UV)
visible
spectroscopy,
Fourier
transform
infrared
(FT‐IR),
X‐ray
diffractometer
(XRD),
scanning
electron
microscope
(SEM),
nuclear
magnetic
resonance
(NMR).
SBE‐β‐CD
as
an
excipient
significantly
enhances
solubility
GLD,
SBE‐β‐CD/GLD
showed
excellent
biocompatibility
on
human
vascular
endothelial
cells
(HUVECs)
erythrocytes.
exerted
pronounced
activity
Staphylococcus
aureus
Escherichia
coli
vitro.
markedly
enhanced
antioxidant
compared
with
free
GLD.
potently
accelerates
skin
defects
inhibiting
inflammation.
outcomes
suggest
that
could
be
used
promising
drug
delivery
system
for
