International Journal of Cosmetic Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 18, 2025
Abstract
Objective
The
açaí
(
Euterpe
oleracea
),
a
palm
tree
fruit
native
to
the
Amazon
region,
holds
significant
potential
for
various
applications
in
food,
therapeutics
and
cosmetics.
However,
seeds
of
fruit,
known
contain
numerous
antioxidants,
are
discarded
frequently
cause
environmental
pollution.
Therefore,
this
study
aimed
explore
application
standardized
extract
(TI‐35)
as
cosmetic
product.
Methods
Açai
were
obtained
from
commercial
source.
Following
preparations
phytochemical
identification
quantification
main
constituents
present
(TI‐35),
several
vitro
studies
performed
using
human
cell
line
cultures.
TI‐35
was
evaluated
on
viability
(human
keratinocytes,
fibroblasts
melanocytes),
proliferation
(keratinocytes),
antioxidant
activity
(keratinocytes
fibroblasts),
melanin
content
(melanocytes),
metalloproteinase‐1
(MMP‐1)
tyrosinase
inhibition
assays.
Skin
irritation
assessed
reconstructed
epidermis
mutagenic
evaluated,
according
OECD
439
471,
respectively.
Results
A
total
14
constituents,
mainly
phenolic
compounds,
identified
quantified
TI‐35.
It
demonstrated
excellent
long‐lasting
stability
exhibited
intrinsic
surpassing
that
ascorbic
acid.
At
low
concentrations
(up
10
μg/mL),
did
not
change
or
proliferation.
decreased
basal
reactive
oxygen
species
production
produced
pronounced
scavenging
effects.
Notably,
caused
MMP‐1
its
effect
more
when
compared
with
either
acid
ferulic
acid,
highlighting
pro‐aging
property.
In
addition,
interfere
levels
have
skin
has
no
activity,
providing
solid
assurance
safety
E.
use.
Conclusion
TI‐35,
sourced
seeds,
by‐product
food
industry,
noteworthy
pharmacological
properties
vitro,
including
antioxidant,
photoprotective,
soothing
sagging
Thus,
emerges
safe
option
development
innovative
products.
Molecules,
Год журнала:
2022,
Номер
27(24), С. 8818 - 8818
Опубликована: Дек. 12, 2022
The
biological
activity
of
natural
plant-oil-based
nanostructured
lipid
carriers
(NPO-NLCs)
can
be
enhanced
by
the
encapsulation
bioactive
compounds,
and
they
in
turn
improve
topical
delivery
drugs.
Quercetin
(QR),
a
vital
plant
flavonoid,
expresses
antibacterial
properties,
we
recently
showed
that
empty
NPO-NLCs
also
have
antimicrobial
activity.
main
objective
this
study
was
to
evaluate
synergetic
effect
loading
with
quercetin
(QR-NPO-NLCs)
as
system
for
treatment
bacterial
skin
infections.
Five
carrier
systems
containing
different
oils
(sunflower,
olive,
corn,
coconut,
castor)
were
engineered.
particles’
stability,
structural
bioavailability,
studied.
NLCs
an
average
size
<200
nm
Z-potential
−40
mV
developed.
Stable
QR-NPO-NLCs
obtained
high
efficiency
(>99%).
QR
decreased
cytotoxicity
increased
antioxidant
nanocarriers.
An
increase
demonstrated
against
Staphylococcus
aureus.
could
transport
intranuclear
location
within
HaCaT
cells,
indicating
are
promising
candidates
controlled
drug
delivery.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(12), С. 10286 - 10286
Опубликована: Июнь 17, 2023
In
this
study,
an
attempt
was
made
to
evaluate
the
antioxidant,
anti-inflammatory
and
protective
effects
of
Sambucus
nigra
fruit
extract
its
ferment
obtained
by
fermentation
with
kombucha
tea
fungus.
For
purpose,
fermented
non-fermented
extracts
were
compared
in
terms
their
chemical
composition
HPLC/ESI-MS
chromatographic
method.
The
antioxidant
activity
tested
samples
assessed
using
DPPH
ABTS
assays.
Cytotoxicity
also
determined
Alamar
Blue
Neutral
Red
tests
assess
viability
metabolism
fibroblast
keratinocyte
skin
cells.
Potential
anti-aging
properties
ability
inhibit
metalloproteinases
collagenase
elastase.
Tests
showed
that
have
stimulate
proliferation
both
cell
types.
study
monitoring
levels
pro-inflammatory
interleukins
IL-6,
IL-1ß,
tumor
necrosis
factor
(TNF-α)
IL-10
lipopolysaccharide
(LPS)-treated
results
indicate
S.
can
be
effective
preventing
free-radical-induced
damage
positive
on
health.
Pharmaceutics,
Год журнала:
2024,
Номер
16(12), С. 1561 - 1561
Опубликована: Дек. 6, 2024
One
of
the
major
challenges
in
dermal
drug
delivery
is
adequate
penetration
active
compound
into
skin
without
causing
any
irritation
and
inflammation.
Nanocrystals
(NCs)
are
nanoscale
particles,
their
sizes
below
1000
nm.
NCs
made
up
particles
only,
which
used
to
improve
aqueous
solubility
bioavailability
poorly
water-soluble
drugs.
typically
prepared
either
by
bottom-up
or
top-down
techniques.
The
advantages
using
NC-based
formulations
enhancing
include
increased
loading
capacity,
easier
deeper
tissue,
passive
diffusion.
with
capacity
enhanced
can
be
effectively
treat
a
wide
range
disorders,
including
melanoma,
inflammation,
psoriasis,
acne
vulgaris,
bacterial
infections,
fungal
eczema,
aging,
herpes
simplex
virus
manifestations
tick
bites,
frostbite-related
hyperpigmentation,
diabetic
foot
ulcer.
In
this
review,
across
barrier,
mechanism
action
NCs,
delivery,
NC
preparation
methods,
applications
treatment
various
disorders
have
been
discussed.
International Journal of Cosmetic Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 18, 2025
Abstract
Objective
The
açaí
(
Euterpe
oleracea
),
a
palm
tree
fruit
native
to
the
Amazon
region,
holds
significant
potential
for
various
applications
in
food,
therapeutics
and
cosmetics.
However,
seeds
of
fruit,
known
contain
numerous
antioxidants,
are
discarded
frequently
cause
environmental
pollution.
Therefore,
this
study
aimed
explore
application
standardized
extract
(TI‐35)
as
cosmetic
product.
Methods
Açai
were
obtained
from
commercial
source.
Following
preparations
phytochemical
identification
quantification
main
constituents
present
(TI‐35),
several
vitro
studies
performed
using
human
cell
line
cultures.
TI‐35
was
evaluated
on
viability
(human
keratinocytes,
fibroblasts
melanocytes),
proliferation
(keratinocytes),
antioxidant
activity
(keratinocytes
fibroblasts),
melanin
content
(melanocytes),
metalloproteinase‐1
(MMP‐1)
tyrosinase
inhibition
assays.
Skin
irritation
assessed
reconstructed
epidermis
mutagenic
evaluated,
according
OECD
439
471,
respectively.
Results
A
total
14
constituents,
mainly
phenolic
compounds,
identified
quantified
TI‐35.
It
demonstrated
excellent
long‐lasting
stability
exhibited
intrinsic
surpassing
that
ascorbic
acid.
At
low
concentrations
(up
10
μg/mL),
did
not
change
or
proliferation.
decreased
basal
reactive
oxygen
species
production
produced
pronounced
scavenging
effects.
Notably,
caused
MMP‐1
its
effect
more
when
compared
with
either
acid
ferulic
acid,
highlighting
pro‐aging
property.
In
addition,
interfere
levels
have
skin
has
no
activity,
providing
solid
assurance
safety
E.
use.
Conclusion
TI‐35,
sourced
seeds,
by‐product
food
industry,
noteworthy
pharmacological
properties
vitro,
including
antioxidant,
photoprotective,
soothing
sagging
Thus,
emerges
safe
option
development
innovative
products.
