Salvia deserti Decne., an endemic and rare subshrub from Arabian desert: antidiabetic and antihyperlipidemic effects of leaf hydroethanolic extracts

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Фев. 10, 2025

Introduction Diabetes is a major health issue that has reached alarming levels worldwide. Although their effectiveness, the antidiabetic drugs have many side effects such as cardiovascular diseases, kidney failure, and hepatic complications. Many plant species of genus Salvia L. “Arabian desert sage” ( deserti ) should began to be focus phytochemical bioactivity studies. Methods The study aims investigate, first-ever, antihyperlipidemic leaf hydroethanolic extract S. deserti, an endemic rare subshrub from Arabian desert. A single intraperitoneal injection alloxan monohydrate (160 mg/kg) was used induce type-2 diabetes. Development diabetes confirmed by measuring blood glucose collected tail vein after 72 h injection. Oral administration extracts at 200 400 mg/kg for 14 days were tested on alloxan-induced diabetic mice animals divided into 6 groups each. identity phenolic compounds S . conducted through HPLC-Electrospray Ionization-Mass Spectrometry (LC-ESI-MS) analyses. Results significantly decreased restored renal function reducing ALT, AST, ALP, GGT, LDH, urea creatinine. An improved lipid profile revealed reduced TC, TG LDL coupled with increased level HDL also observed. Moreover, treatment relieved oxidative stress (reduction MDA H 2 O activity antioxidant enzymes SOD, CAT GPx. presence several (derivatives ferulic, coumaric, caffeic acids, among other derivatives) could least in part explain obtained data empower use source bioactive ingredients antioxidant, properties. Discussion Our research unveiled potential effectively manage its associated dyslipidemia improving status, recovery liver functions presumably increasing insulin secretion sensitivity peripheral tissues insulin.

Язык: Английский

Antioxidant, antidiabetic and molecular docking studies of D-pinitol isolated from Cleistopholis patens (Benth) leaf extract

Discover Chemistry., Год журнала: 2025, Номер 2(1)

Опубликована: Май 26, 2025

Язык: Английский

Exploring the antioxidant and antidiabetic potentials of Syzygium cumini L. landraces: phytochemicals, bioactive constituents and pathway enrichment analysis

International Journal of Food Science & Technology, Год журнала: 2024, Номер 59(8), С. 5818 - 5828

Опубликована: Июль 7, 2024

Summary This study proposes an efficient antidiabetic strategy by identifying potential mechanisms of antioxidant metabolism and α‐amylase inhibition in Syzygium cumini L. fruits. Six indigenous landraces S. were evaluated for major phytochemicals bioactive constituents using gas chromatography–mass spectrometry (GC–MS) profiling correlated with properties. Black jamin landrace‐6 (BJLR‐6), characterised small fruits, exhibited greater 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH) scavenging activity vitro inhibition, especially the kernel. The kernel BJLR‐6 had lowest IC 50 DPPH radicals (4.2 μg mL −1 ) (5.3 ). Therapeutic compounds like terpenoids pulp alkaloids seed contribute to their curative potential. GC–MS revealed propanamide, allantoic acid 2‐furancarboxaldehyde such as piperazine, 3‐pyridinol, imidazole furan carboxaldehyde tissues. Pathway enrichment analysis emphasises insulin‐regulating pathways, steroid hormone signal transduction pathways associated therapeutic/antidiabetic fruit unveils phytochemical composition novel parts small‐fruited BJLR‐6, emphasising a better source functional herbal formulations.

Язык: Английский