Salvia deserti Decne., an endemic and rare subshrub from Arabian desert: antidiabetic and antihyperlipidemic effects of leaf hydroethanolic extracts
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Фев. 10, 2025
Introduction
Diabetes
is
a
major
health
issue
that
has
reached
alarming
levels
worldwide.
Although
their
effectiveness,
the
antidiabetic
drugs
have
many
side
effects
such
as
cardiovascular
diseases,
kidney
failure,
and
hepatic
complications.
Many
plant
species
of
genus
Salvia
L.
“Arabian
desert
sage”
(
deserti
)
should
began
to
be
focus
phytochemical
bioactivity
studies.
Methods
The
study
aims
investigate,
first-ever,
antihyperlipidemic
leaf
hydroethanolic
extract
S.
deserti,
an
endemic
rare
subshrub
from
Arabian
desert.
A
single
intraperitoneal
injection
alloxan
monohydrate
(160
mg/kg)
was
used
induce
type-2
diabetes.
Development
diabetes
confirmed
by
measuring
blood
glucose
collected
tail
vein
after
72
h
injection.
Oral
administration
extracts
at
200
400
mg/kg
for
14
days
were
tested
on
alloxan-induced
diabetic
mice
animals
divided
into
6
groups
each.
identity
phenolic
compounds
S
.
conducted
through
HPLC-Electrospray
Ionization-Mass
Spectrometry
(LC-ESI-MS)
analyses.
Results
significantly
decreased
restored
renal
function
reducing
ALT,
AST,
ALP,
GGT,
LDH,
urea
creatinine.
An
improved
lipid
profile
revealed
reduced
TC,
TG
LDL
coupled
with
increased
level
HDL
also
observed.
Moreover,
treatment
relieved
oxidative
stress
(reduction
MDA
H
2
O
activity
antioxidant
enzymes
SOD,
CAT
GPx.
presence
several
(derivatives
ferulic,
coumaric,
caffeic
acids,
among
other
derivatives)
could
least
in
part
explain
obtained
data
empower
use
source
bioactive
ingredients
antioxidant,
properties.
Discussion
Our
research
unveiled
potential
effectively
manage
its
associated
dyslipidemia
improving
status,
recovery
liver
functions
presumably
increasing
insulin
secretion
sensitivity
peripheral
tissues
insulin.
Язык: Английский
Antioxidant, antidiabetic and molecular docking studies of D-pinitol isolated from Cleistopholis patens (Benth) leaf extract
Discover Chemistry.,
Год журнала:
2025,
Номер
2(1)
Опубликована: Май 26, 2025
Язык: Английский
Exploring the antioxidant and antidiabetic potentials of Syzygium cumini L. landraces: phytochemicals, bioactive constituents and pathway enrichment analysis
International Journal of Food Science & Technology,
Год журнала:
2024,
Номер
59(8), С. 5818 - 5828
Опубликована: Июль 7, 2024
Summary
This
study
proposes
an
efficient
antidiabetic
strategy
by
identifying
potential
mechanisms
of
antioxidant
metabolism
and
α‐amylase
inhibition
in
Syzygium
cumini
L.
fruits.
Six
indigenous
landraces
S.
were
evaluated
for
major
phytochemicals
bioactive
constituents
using
gas
chromatography–mass
spectrometry
(GC–MS)
profiling
correlated
with
properties.
Black
jamin
landrace‐6
(BJLR‐6),
characterised
small
fruits,
exhibited
greater
1,1‐diphenyl‐2‐picrylhydrazyl
(DPPH)
scavenging
activity
vitro
inhibition,
especially
the
kernel.
The
kernel
BJLR‐6
had
lowest
IC
50
DPPH
radicals
(4.2
μg
mL
−1
)
(5.3
).
Therapeutic
compounds
like
terpenoids
pulp
alkaloids
seed
contribute
to
their
curative
potential.
GC–MS
revealed
propanamide,
allantoic
acid
2‐furancarboxaldehyde
such
as
piperazine,
3‐pyridinol,
imidazole
furan
carboxaldehyde
tissues.
Pathway
enrichment
analysis
emphasises
insulin‐regulating
pathways,
steroid
hormone
signal
transduction
pathways
associated
therapeutic/antidiabetic
fruit
unveils
phytochemical
composition
novel
parts
small‐fruited
BJLR‐6,
emphasising
a
better
source
functional
herbal
formulations.
Язык: Английский