4-Chloroskimmetine-based derivatives as potential anticancer and antibacterial prospects: Their synthesis and in vitro inspections

Results in Chemistry, Год журнала: 2024, Номер 7, С. 101511 - 101511

Опубликована: Янв. 1, 2024

Cancer and bacterial infections are among the most high-interest health threats facing humanity. The growing resistance to current-found anticancer antibacterial drugs necessitates exploration of new, effective agents. To synthesize some them, 4-chloroskimmetine (4-CSM), with undefined biological effects, was used as a building block create thirteen its derived coumarins. This precursor Bargellini reaction were produce first coumarin, designated Y0. From which, twelve coumarins coded Y1-Y12 created by esterifying Y0 various halophenols using SOCl2-promoted reaction. FTIR, 1HNMR, 13CNMR spectra analyzed ascertain chemical framework Their potential function prospects evaluated against six cancer-derived populations employing preliminary MTT-facilitated methodology. These MCF-7, HeLa, SKG, AMN3, SK-OV-3, KYSE-30. On other hand, broth microdilution protocol followed specify activity high-infective aerobes. include Pseudomonas aeruginosa, Shigella dysenteriae, Haemophilus influenza, Klebsiella pneumonia, Escherichia coli, Salmonella typhi. results evaluation indicated that presence fluoride on off-side aromatic ring afforded potent activity, Y5 best. For second same findings true, but when halogen is chloride Y2 superior one. authors concluded 4-CSM, can be exploited bioactive activities. Also, considered promising structural templates for producing medications, respectively.

Язык: Английский

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Food-Derived Micronutrients as Alleviators of Age-Related Dysfunction: A Dive into Their Effects and Cellular Mechanisms

Indian Journal of Clinical Biochemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 13, 2025

Язык: Английский

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Unveiling the Biomedical Applications of Novel Coumarins Isolated From Capsicum Annuum L. Seeds by a Multivariate Extraction Technique

Chemistry & Biodiversity, Год журнала: 2024, Номер 21(6)

Опубликована: Апрель 15, 2024

For the first time, kinetic thermomagnetic extraction is a novel approach presented in this work. It required application of four distinct variables: rotation speed (50, 75, and 100 rpm), magnetic field (0.8, 1.2, 1.6 T), time interval (30, 60, 90 min), temperature (45, 55, 65 °C). Numerous phytochemical categories were detected 81 crude chloroform extracts green sweet bell pepper seeds that collected, according to analysis. Nine discovered be linked coumarin chemical class have same two parameters: 90-minute duration 55 °C temperature. To enable their contents chemically separated chromatographically purified, these containing chosen. Four new phytocoumarins been identified molecular structures distinguished using FTIR spectra,

Язык: Английский

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Digital alchemy: Exploring the pharmacokinetic and toxicity profiles of selected coumarin-heterocycle hybrids

Results in Chemistry, Год журнала: 2024, Номер 10, С. 101754 - 101754

Опубликована: Авг. 1, 2024

Язык: Английский

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Chili pepper: A delve into its nutritional values and roles in food-based therapy

Food Chemistry Advances, Год журнала: 2025, Номер 6, С. 100928 - 100928

Опубликована: Фев. 16, 2025

Язык: Английский

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Role of Fruit-Derived Antioxidants in Fighting Cancer: A Narrative Review

Indian Journal of Clinical Biochemistry, Год журнала: 2025, Номер unknown

Опубликована: Фев. 18, 2025

Язык: Английский

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Telomerase in cancer- ongoing quest and future discoveries

Molecular Biology Reports, Год журнала: 2025, Номер 52(1)

Опубликована: Янв. 25, 2025

Язык: Английский

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Biocompatible New Coumarins as Dual-Target Anti-Inflammatory Agents: Insights from Chemistry to Toxicity

Next research., Год журнала: 2025, Номер unknown, С. 100236 - 100236

Опубликована: Март 1, 2025

Язык: Английский

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Linear pyranocoumarins are potential dazzling dancers between nature, chemistry, and clinical application

Phytomedicine Plus, Год журнала: 2025, Номер unknown, С. 100785 - 100785

Опубликована: Март 1, 2025

Язык: Английский

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Capsicum in Clinical Biochemistry: Insights into its Role in Health and Disease

Indian Journal of Clinical Biochemistry, Год журнала: 2025, Номер unknown

Опубликована: Март 25, 2025

Язык: Английский

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