Interdisciplinary cancer research, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Язык: Английский
ChemistrySelect, Год журнала: 2024, Номер 9(47)
Опубликована: Дек. 1, 2024
Abstract Telomerase (TERT) is a ribonucleoprotein that regulates telomere length and maintains chromosomal integrity. TERT widely expressed protein for replicative immortality in most malignant tumours. produced by cancer cells prevents shortening adding sequences beyond the Hayflick limit, allowing them to divide an uncontrolled manner. Inhibition of enzyme recognised therapy treating cancer. The basic objective review collectively represent current scenario inhibiting TERT. With focus on recently patented inhibitors clinical trial data released between 2015 2023, this highlights work relevant development inhibitors. Furthermore, recent advancements inhibitors, along with prospective new combinations, are also discussed. use has been granted great interest significant attention researchers promising outcome terms therapeutic value. Several applications their gave strong evidence which provided target therapies, vaccine nucleoside, non‐nucleoside so forth reduced side effects enhanced potency.
Язык: Английский
Процитировано
2
Cancer Pathogenesis and Therapy, Год журнала: 2024, Номер 2(4), С. 318 - 320
Опубликована: Июнь 21, 2024
Язык: Английский
Процитировано
0
International Journal of Advancement in Life Sciences Research, Год журнала: 2024, Номер 07(03), С. 37 - 54
Опубликована: Янв. 1, 2024
The integumentary system, including the skin, is essential to human body. It acts as a crucial defensive mechanism against many environmental conditions, particularly prolonged exposure sunlight that contains harmful ultraviolet radiation. Exposure this factor initiates series of events ultimately damage genetic material in skin cells, leading unregulated cell proliferation and subsequent formation malignancies. UV spectrum consists two main categories, UVA UVB, each having different effects on environment. They cause cellular stress directly DNA. A growing academic discussion focuses understanding diets health, specifically comparing western diet, which includes lot processed food, with asian encompasing natural plant-based remedies. This variation food habits has been suggested affects skin's general health. "Nutraceuticals" refers substances derived from sources function powerful preventive barrier developing advancing tumors. Intentionally nutraceuticals one's entails precise enrichment minerals, vitamins, vital fatty acids, can improve conditions strengthen resistance cancer-causing propensities. comprehensive review aims clarify complex relationship between cancers potential nutraceutical therapies, highlighting their beneficial effect preventing development gained research highlights importance certain bioactive chemicals obtained nature promoting healthy reducing likelihood malignant changes.
Язык: Английский
Процитировано
0
Medical Oncology, Год журнала: 2024, Номер 42(1)
Опубликована: Ноя. 25, 2024
Язык: Английский
Процитировано
0
Interdisciplinary cancer research, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
0